🔖Protip: Good and bad responders
Many people talk about the genetic response to steroids, of "good" and "bad" responders to these compounds, your product may not be underdosed but because of your genetics you do not respond in the same way as the rest (without having taking into account variables such as diet, training and rest), science has not delved much into this subject, but it has given us some answers that may be useful.
👨🏼🔬It has been found that most of the hydrolysis of esters is carried out by the PDE7B gene, in a study 500mg of testosterone enanthate was administered to see the different responses of users to this steroid.
❕The "good" responders who had the A allele obtained an average of 3.9 times higher levels 📈 than the basal level after the administration of 500mg of testosterone enanthate, the "bad" responders who had the G allele obtained an average increase of 2.5 times the baseline levels after the administration of 500mg of testosterone.
🔬We could imitate this test, injecting 500mg of testosterone enanthate and analyzing total testosterone concentrations 48 hours after administration ⏱ (if its possible knowing that the testosterone concentration is correct or if we lack this data, we could compare our bloodwork with those subjects with the same batch and dose) if our levels are between 13-14ng / mL or close to these levels it would mean that we are bad responders ✖️, close to 19ng / mL would mean that we are good responders ✔️ and levels above this range would be what are known clinically as “outliers” 🦾.
📝If you are a "bad" responder, I would recommend using short esters (because the problem usually lies in the difficulty of hydrolyzing the ester) and using oral drugs as they lack an ester and have an immediate effect ✅.
#Protip #Genetics #Responders
Many people talk about the genetic response to steroids, of "good" and "bad" responders to these compounds, your product may not be underdosed but because of your genetics you do not respond in the same way as the rest (without having taking into account variables such as diet, training and rest), science has not delved much into this subject, but it has given us some answers that may be useful.
👨🏼🔬It has been found that most of the hydrolysis of esters is carried out by the PDE7B gene, in a study 500mg of testosterone enanthate was administered to see the different responses of users to this steroid.
❕The "good" responders who had the A allele obtained an average of 3.9 times higher levels 📈 than the basal level after the administration of 500mg of testosterone enanthate, the "bad" responders who had the G allele obtained an average increase of 2.5 times the baseline levels after the administration of 500mg of testosterone.
🔬We could imitate this test, injecting 500mg of testosterone enanthate and analyzing total testosterone concentrations 48 hours after administration ⏱ (if its possible knowing that the testosterone concentration is correct or if we lack this data, we could compare our bloodwork with those subjects with the same batch and dose) if our levels are between 13-14ng / mL or close to these levels it would mean that we are bad responders ✖️, close to 19ng / mL would mean that we are good responders ✔️ and levels above this range would be what are known clinically as “outliers” 🦾.
📝If you are a "bad" responder, I would recommend using short esters (because the problem usually lies in the difficulty of hydrolyzing the ester) and using oral drugs as they lack an ester and have an immediate effect ✅.
#Protip #Genetics #Responders
🔖Protip: Genetics and Fatloss
Genetics greatly influences fat loss, depending on your genes there will be a specific type of diet that is better.
FABP2 (rs1799883)
FABP2 refers to the intestinal fatty acid binding protein 2, which is a protein located in the cytosol of the intestinal epithelium and is associated with the metabolism of long chain fatty acids.
🧬At rs1799883 a transition occurs at codon 54 resulting in a replacement of Alanine (Ala) with Threonine (Tr), the wild-type allele pattern for FABP2 is Ala / Ala while the mutant is Ala / Tr or Tr / Tr.
👨🏼🔬People with the mutant-type allele pattern would take advantage of a low-carb, high-fat 🍕 diet while people with the wild-type allele pattern would take more advantage of a high-carb 🍞, low-fat diet.
PPARG2 (rs1801282)
This is the peroxisome proliferator activated receptor gamma-2 gene, which is an isoform of the PPARG gene. PPARG2 is found mainly in adipocytes and has a very important role in adipocyte differentiation.
🧬At codon 12 of exon B in rs18001282 a mutation occurs consisting of a transition from alanine (Ala) to proline (Pro). The wild type allele pattern of PPARG2 is Pro / Pro, while the mutant type is Pro / Ala or Ala / Ala.
👨🏼🔬People with the mutant-type allele pattern would benefit more from a low-fat, high-carbohydrate 🍞 diet.
ADRB3 (rs4994)
This is the beta-3 adrenergic receptor gene, which is found mainly in adipocytes and its function is related to lipid metabolism and thermogenesis.
🧬At codon 64, a mutation can occur consisting of a transition from tryptophan (Trp) to arginine (Arg). The wild type allele pattern is Trp / Trp while the mutant type is Arg / Arg or Trp / Arg.
👨🏼🔬People with the mutant-type allele pattern would benefit more from a moderate carbohydrate and fat diet, those with a wild-type allele pattern would take advantage of a very high intake of PUFAs ✔️.
ADRB2 (rs1042713 and rs1041714)
This is the beta-2 adrenergic receptor gene which is distributed throughout the body, with a large presence in adipocytes and plays a very important role in lipid metabolism and thermogenesis.
The two most common genetic mutations in this gene occur at codons 16 and 27, respectively.
🧬At codon 16 (rs1042713) arginine (Arg) replaces glycine (Gly); the homozygous allele pattern for Glycine is that of the wild type (Gly / Gly) while the other two are of the mutant type.
🧬At codon 27 (rs1041714) glutamic acid (Glu) replaces glutamine (Gln); the homozygous allele pattern for Glutamine is of the wild type (Gln / Gln) while the other two are of the mutant type.
👨🏼🔬People with a wild-type allele pattern at codon 16 would need a greater caloric deficit 📉 to achieve the same weight loss , the same would happen for those with a mutant-type allele pattern at codon 27 ❌.
#Genetics #Fatloss #Protip
Genetics greatly influences fat loss, depending on your genes there will be a specific type of diet that is better.
FABP2 (rs1799883)
FABP2 refers to the intestinal fatty acid binding protein 2, which is a protein located in the cytosol of the intestinal epithelium and is associated with the metabolism of long chain fatty acids.
🧬At rs1799883 a transition occurs at codon 54 resulting in a replacement of Alanine (Ala) with Threonine (Tr), the wild-type allele pattern for FABP2 is Ala / Ala while the mutant is Ala / Tr or Tr / Tr.
👨🏼🔬People with the mutant-type allele pattern would take advantage of a low-carb, high-fat 🍕 diet while people with the wild-type allele pattern would take more advantage of a high-carb 🍞, low-fat diet.
PPARG2 (rs1801282)
This is the peroxisome proliferator activated receptor gamma-2 gene, which is an isoform of the PPARG gene. PPARG2 is found mainly in adipocytes and has a very important role in adipocyte differentiation.
🧬At codon 12 of exon B in rs18001282 a mutation occurs consisting of a transition from alanine (Ala) to proline (Pro). The wild type allele pattern of PPARG2 is Pro / Pro, while the mutant type is Pro / Ala or Ala / Ala.
👨🏼🔬People with the mutant-type allele pattern would benefit more from a low-fat, high-carbohydrate 🍞 diet.
ADRB3 (rs4994)
This is the beta-3 adrenergic receptor gene, which is found mainly in adipocytes and its function is related to lipid metabolism and thermogenesis.
🧬At codon 64, a mutation can occur consisting of a transition from tryptophan (Trp) to arginine (Arg). The wild type allele pattern is Trp / Trp while the mutant type is Arg / Arg or Trp / Arg.
👨🏼🔬People with the mutant-type allele pattern would benefit more from a moderate carbohydrate and fat diet, those with a wild-type allele pattern would take advantage of a very high intake of PUFAs ✔️.
ADRB2 (rs1042713 and rs1041714)
This is the beta-2 adrenergic receptor gene which is distributed throughout the body, with a large presence in adipocytes and plays a very important role in lipid metabolism and thermogenesis.
The two most common genetic mutations in this gene occur at codons 16 and 27, respectively.
🧬At codon 16 (rs1042713) arginine (Arg) replaces glycine (Gly); the homozygous allele pattern for Glycine is that of the wild type (Gly / Gly) while the other two are of the mutant type.
🧬At codon 27 (rs1041714) glutamic acid (Glu) replaces glutamine (Gln); the homozygous allele pattern for Glutamine is of the wild type (Gln / Gln) while the other two are of the mutant type.
👨🏼🔬People with a wild-type allele pattern at codon 16 would need a greater caloric deficit 📉 to achieve the same weight loss , the same would happen for those with a mutant-type allele pattern at codon 27 ❌.
#Genetics #Fatloss #Protip
☝🏻Nature vs Nurture – the importance of genetics in body building
Bodybuilding is a popular hobby, but have you ever stopped to think about what makes some people better at it than others? Genetics play a significant role in bodybuilding and if you’re not blessed with the right genes, you might as well stick to collecting stamps.
In fact, when it comes to bodybuilding, some people have it easier than others. If you’re born with the right genes, you could have an unfair advantage over the rest of us mere mortals. You might have a fast metabolism, making it easier for you to stay lean and shredded. You could have more type II muscle fibers, which are well suited for explosive power and strength. In addition, let’s not forget about muscle shape – some folks are born with biceps that pop like balloons, while others have to make do with spaghetti arms.
#Bodybuilding #Genes #Genetics #Training
CONTINUE READING
Bodybuilding is a popular hobby, but have you ever stopped to think about what makes some people better at it than others? Genetics play a significant role in bodybuilding and if you’re not blessed with the right genes, you might as well stick to collecting stamps.
In fact, when it comes to bodybuilding, some people have it easier than others. If you’re born with the right genes, you could have an unfair advantage over the rest of us mere mortals. You might have a fast metabolism, making it easier for you to stay lean and shredded. You could have more type II muscle fibers, which are well suited for explosive power and strength. In addition, let’s not forget about muscle shape – some folks are born with biceps that pop like balloons, while others have to make do with spaghetti arms.
#Bodybuilding #Genes #Genetics #Training
CONTINUE READING
Steroidify Blog
Nature vs Nurture – the importance of genetics in body building - Steroidify Blog
While genetics aren't everything when it comes to building muscle, they certainly play a big role. Whether you were born with the perfect physique or have to work a little harder for it, with the right mindset and approach, you can achieve your fitness goals.…
☝🏻 5 new ways we’re fighting cancer – a promising future for patients
Cancer continues to be a formidable global health challenge, affecting millions of lives each and every year. Despite the progresses made in the prevention, early diagnosis, and treatment of various cancer types, finding a definitive cure has remained yet a distant goal for medical researchers. However, in recent years, the field of cancer research has witnessed a surge of groundbreaking advancements, offering new hope and possibilities for patients worldwide. In this article, we will take a look at five of the most recent and promising developments in cancer cure.
#DidYouKnow #Genetics #HarmPrevention
CONTINUE READING
Cancer continues to be a formidable global health challenge, affecting millions of lives each and every year. Despite the progresses made in the prevention, early diagnosis, and treatment of various cancer types, finding a definitive cure has remained yet a distant goal for medical researchers. However, in recent years, the field of cancer research has witnessed a surge of groundbreaking advancements, offering new hope and possibilities for patients worldwide. In this article, we will take a look at five of the most recent and promising developments in cancer cure.
#DidYouKnow #Genetics #HarmPrevention
CONTINUE READING
Steroidify Blog
5 new ways we’re fighting cancer – a promising future for patients - Steroidify Blog
he recent advances in cancer cure mark a paradigm shift in how we approach this complex disease. From harnessing the power of the patient’s own immune system to tailoring treatments to individual patients, these breakthroughs have reignited hope for millions…