Night #Shift Work and #Breast Cancer Incidence: Three Prospective Studies and Meta-analysis of Published Studies

http://m.jnci.oxfordjournals.org/content/108/12/djw169

Conclusions: The totality of the prospective evidence shows that night shift work, including long-term shift work, has little or no effect on breast cancer incidence.

Night #Shift Work Increases the Risks of Multiple Primary #Cancers in Women: A Systematic Review and Meta-analysis of 61 Articles
http://cebp.aacrjournals.org/content/27/1/25

A positive relationship was revealed between long-term night shift work and the risks of breast [OR = 1.316; 95% confidence interval (CI), 1.196–1.448], digestive system (OR = 1.177; 95% CI, 1.065–1.301), and skin cancer (OR = 1.408; 95% CI, 1.024–1.934). For every 5 years of night shift work, the risk of breast cancer in women was increased by 3.3% (OR = 1.033; 95% CI, 1.012–1.056). Concerning the group of nurses, long-term night shift work presented potential carcinogenic effect in breast cancer (OR = 1.577; 95% CI, 1.235–2.014), digestive system cancer (OR = 1.350; 95% CI, 1.030–1.770), and lung cancer (OR = 1.280; 95% CI, 1.070–1.531). This systematic review confirmed the positive association between night shift work and the risks of several common cancers in women. We identified that cancer risk of women increased with accumulating years of night shift work, which might help establish and implement effective measures to protect female night shifters.

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Rotating night #shift work and adherence to unhealthy lifestyle in predicting risk of type 2 #diabetes: results from two large US cohorts of female nurses

https://www.bmj.com/content/363/bmj.k4641

During 22-24 years of follow-up, 10 915 cases of incident type 2 diabetes occurred. The multivariable adjusted hazard ratios for type 2 diabetes were 1.31 (95% confidence interval 1.19 to 1.44) per five year increment of duration of rotating night shift work and 2.30 (1.88 to 2.83) per unhealthy lifestyle factor (ever smoking, low diet quality, low physical activity, and overweight or obesity). For the joint association of per five year increment rotating night shift work and per unhealthy lifestyle factor with type 2 diabetes, the hazard ratio was 2.83 (2.15 to 3.73) with a significant additive interaction (P for interaction <0.001). The proportions of the joint association were 17.1% (14.0% to 20.8%) for rotating night shift work alone, 71.2% (66.9% to 75.8%) for unhealthy lifestyle alone, and 11.3% (7.3% to 17.3%) for their additive interaction.

Conclusions Among female nurses, both rotating night shift work and unhealthy lifestyle were associated with a higher risk of type 2 diabetes. The excess risk of rotating night shift work combined with unhealthy lifestyle was higher than the addition of risk associated with each individual factor. These findings suggest that most cases of type 2 diabetes could be prevented by adhering to a healthy lifestyle, and the benefits could be greater in rotating night shift workers.

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#Shift Workers at Risk for #Metabolic Syndrome

In this highly digitalized era, sleep disorders are becoming more common and are associated with an increased burden of chronic disease. Shift workers are at an increased risk for both sleep disorders and metabolic syndrome. In this article, the authors outline the connection between circadian discordance, hormonal imbalance, and the development of metabolic syndrome in shift workers.

Based on a literature review of animal model studies, observational studies, and clinical trials conducted between August and October of 2018, the authors offer several clinical interventions, including work schedules, light therapy, medications, and dietary habits to improve the circadian synchronicity of shift workers and reduce their risk of morbidity and mortality. It is important for physicians to be familiar with the consequences of shift work and ways to mitigate the risks for this patient population.

https://bit.ly/2SuVlZo

Guiding principles for determining work #shift duration and addressing the effects of work shift duration on performance, safety, and health: guidance from the American Academy of #Sleep Medicine and the Sleep Research Society

https://2medical.news/2021/07/23/guiding-principles-for-determining-work-shift-duration-and-addressing-the-effects-of-work-shift-duration-on-performance-safety-and-health-guidance-from-the-american-academy-of-sleep-medicine-and/

Long-term night #shift work is associated with the risk of atrial #fibrillation and #coronary heart disease

https://2medical.news/2021/08/18/long-term-night-shift-work-is-associated-with-the-risk-of-atrial-fibrillation-and-coronary-heart-disease/