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Aldo Lorenzetti M.D, Internal Medicine & Hepatology, Milano - SIMEDET Delegate
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Impact of #physical activity on the association of overweight and obesity with #cardiovascular disease: The Rotterdam Study

http://journals.sagepub.com/doi/10.1177/2047487317693952

Our findings suggest that the beneficial impact of physical activity on CVD might outweigh the negative impact of body mass index among middle-aged and elderly people. This emphasizes the importance of physical activity for everyone across all body mass index strata, while highlighting the risk associated with inactivity even among normal weight people.
Effect of Changes in #Physical Activity on Risk for Cardiac Death in Patients With #Coronary Artery Disease
http://www.sciencedirect.com/science/article/pii/S0002914917316090

Leisure-time physical activity (LTPA) is associated with longevity in patients with coronary artery disease (CAD) Patients with angiographically documented CAD (n = 1,746) underwent clinical examination and echocardiography at the baseline. Lifestyle factors, including LTPA (inactive, irregularly active, active, highly active), were surveyed at baseline and after 2 years' follow-up. Thereafter, the patients entered the follow-up (median: 4.5 years; first to third quartile: 3.4 to 5.8 years) during which cardiac deaths were registered (n = 68, 3.9%). The patients who remained inactive (n = 114, 18 events, 16%) and became inactive (n = 228, 18 events, 8%) had 7.6- (95% confidence interval CI 4.2 to 13.6) and 3.7-fold (95% CI 2.1 to 6.7) univariate risk for cardiac death compared with those who remained at least irregularly active (n = 1,351, 30 events, 2%), respectively. After adjustment for age, gender, body mass index, diabetes, previous myocardial infarction, left ventricular ejection fraction, angina pectoris grading, cardiovascular event during initial 2-year follow-up, smoking and alcohol consumption, the patients who remained inactive and became inactive still had 4.9- (95% CI 2.4 to 9.8, p <0.001) and 2.4-fold (95% CI 1.3 to 4.5, p <0.01) risk for cardiac death, respectively, compared with patients remaining at least irregularly active.

In conclusion, LTPA has important prognostic value for cardiac death in patients with stable CAD. Even minor changes in LTPA over 2 years were related to the subsequent risk for cardiac death
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Association of Levels of #Physical Activity With Risk of #Parkinson Disease
A Systematic Review and Meta-analysis

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2703134

Eight prospective studies totaling 544 336 participants included 2192 patients with PD with a median (range) follow-up period of 12 (6.1-22.0) years were identified. A significantly reduced risk of PD was associated with the highest levels of either total physical activity (relative risk, 0.79; 95% CI, 0.68-0.91) or moderate to vigorous physical activity (relative risk, 0.71; 95% CI, 0.58-0.87), with stronger associations among men than among women. In contrast, light physical activity was not associated with PD risk (relative risk, 0.86; 95% CI, 0.60-1.23). The dose-response analysis revealed that for each 10 metabolic equivalent of task–hours/week increase in total or moderate to vigorous physical activity, the risk of PD among men decreased by 10% and 17%, respectively. No linear dose-response association was found between physical activity and PD risk among women.

Conclusions and Relevance This analysis revealed an inverse dose-response association between physical activity and PD risk among men; importantly, even moderate exercise was associated with a significant reduction in the risk of PD. Future studies with quantified measurements of physical activity will help identify the precise relative risk estimates for various levels of activity with respect to PD risk
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The #Physical #Activity Guidelines for Americans

https://jamanetwork.com/journals/jama/fullarticle/2712935

Approximately 80% of US adults and adolescents are insufficiently active. Physical activity fosters normal growth and development and can make people feel, function, and sleep better and reduce risk of many chronic diseases.

Children and adolescents aged 6 through 17 years should do 60 minutes or more of moderate-to-vigorous physical activity daily. Adults should do at least 150 minutes to 300 minutes a week of moderate-intensity, or 75 minutes to 150 minutes a week of vigorous-intensity aerobic physical activity, or an equivalent combination of moderate- and vigorous-intensity aerobic activity.

They should also do muscle-strengthening activities on 2 or more days a week. Older adults should do multicomponent physical activity that includes balance training as well as aerobic and muscle-strengthening activities. Pregnant and postpartum women should do at least 150 minutes of moderate-intensity aerobic activity a week. Adults with chronic conditions or disabilities, who are able, should follow the key guidelines for adults and do both aerobic and muscle-strengthening activities.

Recommendations emphasize that moving more and sitting less will benefit nearly everyone. Individuals performing the least physical activity benefit most by even modest increases in moderate-to-vigorous physical activity. Additional benefits occur with more physical activity. Both aerobic and muscle-strengthening physical activity are beneficial.
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#physical inactivity, cardiometabolic disease, and risk of #dementia: an individual-participant meta-analysis

https://www.bmj.com/content/365/bmj.l1495

When measured <10 years before dementia diagnosis (that is, the preclinical stage of dementia), physical inactivity was associated with increased incidence of all-cause dementia (hazard ratio 1.40, 95% confidence interval 1.23 to 1.71) and Alzheimer’s disease (1.36, 1.12 to 1.65). When reverse causation was minimised by assessing physical activity ≥10 years before dementia onset, no difference in dementia risk between physically active and inactive participants was observed (hazard ratios 1.01 (0.89 to 1.14) and 0.96 (0.85 to 1.08) for the two outcomes). Physical inactivity was consistently associated with increased risk of incident diabetes (hazard ratio 1.42, 1.25 to 1.61), coronary heart disease (1.24, 1.13 to 1.36), and stroke (1.16, 1.05 to 1.27). Among people in whom cardiometabolic disease preceded dementia, physical inactivity was non-significantly associated with dementia (hazard ratio for physical activity assessed >10 before dementia onset 1.30, 0.79 to 2.14).

Conclusions In analyses that addressed bias due to reverse causation, physical inactivity was not associated with all-cause dementia or Alzheimer’s disease, although an indication of excess dementia risk was observed in a subgroup of physically inactive individuals who developed cardiometabolic disease.
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#Mental Illness Among Youth With Chronic #Physical Conditions

https://pediatrics.aappublications.org/content/early/2019/06/13/peds.2018-1819

Youth with chronic physical conditions (CPCs) may be at greater risk for developing chronic mental health conditions (MHCs), and limitations in the ability to engage in developmentally appropriate activities may contribute to the risk of MHCs among youth with CPCs.

The 2-year cumulative incidence of MHCs was 7.8% overall, 11.5% in youth with CPCs (14.7% of sample), and 7.1% in those without. The adjusted risk of incident MHCs was 51% greater (adjusted hazard ratio 1.51; 95% confidence interval 1.30–1.74) in youth with CPCs compared with those without. Activity limitations mediated 13.5% of this relationship (P < .001).

CONCLUSIONS: This nationally representative cohort study supports the hypotheses that youth with CPCs have increased risk for MHCs and that activity limitations may play a role in MHC development. Youth with CPCs may benefit from services to bolster their ability to participate in developmentally important activities and to detect and treat new onset MHC
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The Predictive Performance of Objective Measures of #physical Activity Derived From Accelerometry Data for 5-Year All-Cause Mortality in #Older Adults: National Health and Nutritional Examination Survey 2003–2006

Declining physical activity (PA) is a hallmark of aging. Wearable technology provides reliable measures of the frequency, duration, intensity, and timing of PA..

In univariate logistic regression, the total activity count was the best predictor of 5-year mortality (Area under the Curve (AUC) = 0.771) followed by age (AUC = 0.758). Overall, 9 of the top 10 predictors were objective PA measures (AUC from 0.771 to 0.692). In multivariate regression, the 10-fold cross-validated AUC was 0.798 for the model without objective PA variables (9 predictors) and 0.838 for the forward selection model with objective PA variables (13 predictors). The Net Reclassification Index was substantially improved by adding objective PA variables (p < .001).

Conclusions
Objective accelerometry-derived PA measures outperform traditional predictors of 5-year mortality, including age. This highlights the importance of wearable technology for providing reproducible, unbiased, and prognostic biomarkers of health.

https://academic.oup.com/biomedgerontology/advance-article-abstract/doi/10.1093/gerona/glz193/5555985
Amount and Intensity of Leisure-Time #Physical Activity and Lower #Cancer Risk

To determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk..

..Engagement in recommended amounts of activity (7.5-15 MET hours/week) was associated with a statistically significant lower risk of 7 of the 15 cancer types studied, including colon (8%-14% lower risk in men), breast (6%-10% lower risk), endometrial (10%-18% lower risk), kidney (11%-17% lower risk), myeloma (14%-19% lower risk), liver (18%-27% lower risk), and non-Hodgkin lymphoma (11%-18% lower risk in women). The dose response was linear in shape for half of the associations and nonlinear for the others. Results for moderate- and vigorous-intensity leisure-time physical activity were mixed. Adjustment for body mass index eliminated the association with endometrial cancer but had limited effect on other cancer types.

CONCLUSION

Health care providers, fitness professionals, and public health practitioners should encourage adults to adopt and maintain physical activity at recommended levels to lower risks of multiple cancers.

https://bit.ly/2F1Qfwj
Association Between #Weight Loss and Spontaneous Changes in #Physical Inactivity in Overweight/Obese Individuals With Knee Osteoarthritis: An Eight‐Week Prospective Cohort Study
https://2medical.news/2020/03/07/association-between-weight-loss-and-spontaneous-changes-in-physical-inactivity-in-overweight-obese-individuals-with-knee-osteoarthritis-an-eight%E2%80%90week-prospective-cohort-study/

To describe spontaneous changes in time spent being physically inactive that is measured continuously by accelerometry during an 8‐week weight‐loss intervention in overweight/obese individuals with knee osteoarthritis (OA).. A total of 124 participants completed the dietary intervention and had valid accelerometer recordings. The mean weight loss was 12.7 kg (95% confidence interval [95% CI] –13.2, –12.1; P < 0.0001) after 8 weeks, which corresponded to …
Effect of time of day of recreational and household #physical activity on prostate and breast #cancer risk (MCC‐Spain study)
https://2medical.news/2020/10/22/effect-of-time-of-day-of-recreational-and-household-physical-activity-on-prostate-and-breast-cancer-risk-mcc%E2%80%90spain-study/

Experimental evidence indicates that exercise performed at different times of the day may affect circadian rhythms and circadian disruption has been linked to breast and prostate cancer. We examined in a population‐based case‐control study (MCC‐Spain) if the time‐of‐day when physical activity is done affects prostate and breast cancer risk. Lifetime recreational and household physical activity was assessed by in‐person interviews. Information on time‐of‐day of activity …
Inadequate #Physical Activity and #Sedentary Behavior Are Independent Predictors of Nonalcoholic Fatty #Liver Disease
https://2medical.news/2020/10/30/inadequate-physical-activity-and-ssedentary-behavior-are-independent-predictors-of-nonalcoholic-fatty-liver-disease/

In general, physical activity (PA) and nonalcoholic fatty liver disease (NAFLD) have an inverse association. However, studies assessing the impact of the widely accepted Physical Activity Guidelines for Americans (PA Guidelines) on NAFLD are lacking. We performed a serial, cross‐sectional analysis among adults by using the 2007‐2016 US National Health and Nutrition Examination Survey. NAFLD and advanced fibrosis were defined by using various noninvasive panels. …
#Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease
https://2medical.news/2021/02/22/physical-activity-may-not-be-associated-with-long%E2%80%90term-risk-of-dementia-and-alzheimers-disease/

While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer’s disease (AD). Material and methods We analysed data on 2394 apparently healthy men with good baseline …