The Risk of Head #Injuries Associated With Antipsychotic Use Among Persons With #Alzheimer's disease
Antipsychotic use is associated with risk of falls among older persons, but we are not aware of previous studies investigating risk of head injuries. We studied the association of antipsychotic use and risk of head injuries among community dwellers with Alzheimer's disease (AD)
..Antipsychotic use was associated with an increased risk of head injuries (event rate per 100 person‐years = 1.65 [95% confidence interval {CI} = 1.50‐1.81] for users and 1.26 [95% CI = 1.16‐1.37] for nonusers; IPT‐weighted hazard ratio [HR] = 1.29 [95% CI = 1.14‐1.47]) and TBIs (event rate per 100 person‐years = 0.90 [95% CI = 0.79‐1.02] for users and 0.72 [95% CI = 0.65‐0.81] for nonusers; IPT‐weighted HR = 1.22 [95% CI = 1.03‐1.45]). Quetiapine users had higher risk of TBIs (IPT‐weighted HR = 1.60 [95% CI = 1.15‐2.22]) in comparison to risperidone users.
CONCLUSIONS
These findings imply that in addition to previously reported adverse events and effects, antipsychotic use may increase the risk of head injuries and TBIs in persons with AD. Therefore, their use should be restricted to most severe neuropsychiatric symptoms, as recommended by the AGS Beers Criteria®. Additionally, higher relative risk of TBIs in quetiapine users compared to risperidone users should be confirmed in further studies.
https://bit.ly/2R2ESK3
Antipsychotic use is associated with risk of falls among older persons, but we are not aware of previous studies investigating risk of head injuries. We studied the association of antipsychotic use and risk of head injuries among community dwellers with Alzheimer's disease (AD)
..Antipsychotic use was associated with an increased risk of head injuries (event rate per 100 person‐years = 1.65 [95% confidence interval {CI} = 1.50‐1.81] for users and 1.26 [95% CI = 1.16‐1.37] for nonusers; IPT‐weighted hazard ratio [HR] = 1.29 [95% CI = 1.14‐1.47]) and TBIs (event rate per 100 person‐years = 0.90 [95% CI = 0.79‐1.02] for users and 0.72 [95% CI = 0.65‐0.81] for nonusers; IPT‐weighted HR = 1.22 [95% CI = 1.03‐1.45]). Quetiapine users had higher risk of TBIs (IPT‐weighted HR = 1.60 [95% CI = 1.15‐2.22]) in comparison to risperidone users.
CONCLUSIONS
These findings imply that in addition to previously reported adverse events and effects, antipsychotic use may increase the risk of head injuries and TBIs in persons with AD. Therefore, their use should be restricted to most severe neuropsychiatric symptoms, as recommended by the AGS Beers Criteria®. Additionally, higher relative risk of TBIs in quetiapine users compared to risperidone users should be confirmed in further studies.
https://bit.ly/2R2ESK3
Wiley Online Library
The Risk of Head Injuries Associated With Antipsychotic Use Among Persons With Alzheimer's disease
BACKGROUND/OBJECTIVES
Antipsychotic use is associated with risk of falls among older persons, but we are not aware of previous studies investigating risk of head injuries. We studied the association...
Antipsychotic use is associated with risk of falls among older persons, but we are not aware of previous studies investigating risk of head injuries. We studied the association...
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Efficacy and Safety of #Lanabecestat for Treatment of Early and Mild #Alzheimer Disease
Does lanabecestat, a potent inhibitor of the beta-site amyloid precursor protein–cleaving enzyme 1 (BACE1), slow the progression of early Alzheimer disease (AD) and mild AD dementia?..
..Among 1722 DAYBREAK-ALZ patients, the mean (SD) age was 72.3 (7.0) years, and 1023 of 1722 (59.4%) were women. Both studies were terminated early after futility analysis. There were no consistent, reproducible dose-related findings on primary or secondary efficacy measures. Psychiatric adverse events, weight loss, and hair color changes were reported in a higher percentage of patients receiving lanabecestat than placebo.
Conclusions and Relevance Treatment with lanabecestat was well tolerated and did not slow cognitive or functional decline.
https://bit.ly/322A2BO
Efficacy and Safety of #Lanabecestat for Treatment of Early and Mild #Alzheimer Disease
Does lanabecestat, a potent inhibitor of the beta-site amyloid precursor protein–cleaving enzyme 1 (BACE1), slow the progression of early Alzheimer disease (AD) and mild AD dementia?..
..Among 1722 DAYBREAK-ALZ patients, the mean (SD) age was 72.3 (7.0) years, and 1023 of 1722 (59.4%) were women. Both studies were terminated early after futility analysis. There were no consistent, reproducible dose-related findings on primary or secondary efficacy measures. Psychiatric adverse events, weight loss, and hair color changes were reported in a higher percentage of patients receiving lanabecestat than placebo.
Conclusions and Relevance Treatment with lanabecestat was well tolerated and did not slow cognitive or functional decline.
https://bit.ly/322A2BO
Jamanetwork
Efficacy and Safety of Lanabecestat for Treatment of Early and Mild Alzheimer Disease
The AMARANTH and DAYBREAK-ALZ randomized clinical trials assess whether lanabecestat slows the progression of Alzheimer disease compared with placebo in patients with early Alzheimer disease or mild Alzheimer disease dementia.
Long-term dietary #flavonoid intake and risk of #Alzheimer disease and related dementias in the Framingham Offspring Cohort
https://2medical.news/2020/05/23/long-term-dietary-flavonoid-intake-and-risk-of-alzheimer-disease-and-related-dementias-in-the-framingham-offspring-cohort/
Findings from existing prospective observational studies on the protective associations of flavonoid intake and the risk of Alzheimer disease and related dementias (ADRD) are inconsistent largely due to limitations of these studies.. ..Over an average follow-up of 19.7 y in 2801 participants (mean baseline age = 59.1 y; 52% females), there were 193 ADRD events of which 158 were AD. After multivariate and dietary adjustments, …
https://2medical.news/2020/05/23/long-term-dietary-flavonoid-intake-and-risk-of-alzheimer-disease-and-related-dementias-in-the-framingham-offspring-cohort/
Findings from existing prospective observational studies on the protective associations of flavonoid intake and the risk of Alzheimer disease and related dementias (ADRD) are inconsistent largely due to limitations of these studies.. ..Over an average follow-up of 19.7 y in 2801 participants (mean baseline age = 59.1 y; 52% females), there were 193 ADRD events of which 158 were AD. After multivariate and dietary adjustments, …
Healthy #lifestyle and the risk of #Alzheimer dementia
https://2medical.news/2020/06/26/healthy-lifestyle-and-the-risk-of-alzheimer-dementia/
Using data from the Chicago Health and Aging Project (CHAP; n = 1,845) and the Rush Memory and Aging Project (MAP; n = 920), we defined a healthy lifestyle score on the basis of nonsmoking, ≥150 min/wk moderate/vigorous-intensity physical activity, light to moderate alcohol consumption, high-quality Mediterranean-DASH Diet.. ..During a median follow-up of 5.8 years in CHAP and 6.0 years in MAP, 379 and 229 …
https://2medical.news/2020/06/26/healthy-lifestyle-and-the-risk-of-alzheimer-dementia/
Using data from the Chicago Health and Aging Project (CHAP; n = 1,845) and the Rush Memory and Aging Project (MAP; n = 920), we defined a healthy lifestyle score on the basis of nonsmoking, ≥150 min/wk moderate/vigorous-intensity physical activity, light to moderate alcohol consumption, high-quality Mediterranean-DASH Diet.. ..During a median follow-up of 5.8 years in CHAP and 6.0 years in MAP, 379 and 229 …
CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of #Alzheimer’s disease
https://2medical.news/2020/08/19/cms121-a-fatty-acid-synthase-inhibitor-protects-against-excess-lipid-peroxidation-and-inflammation-and-alleviates-cognitive-loss-in-a-transgenic-mouse-model-of-alzheimers-disease/
The oxidative degradation of lipids has been shown to be implicated in the progression of several neurodegenerative diseases and modulating lipid peroxidation may be efficacious for treating Alzheimer’s disease (AD). This hypothesis is strengthened by recent findings suggesting that oxytosis/ferroptosis, a cell death process characterized by increased lipid peroxidation, plays an important role in AD-related toxicities. CMS121 is a small molecule developed against these aspects …
https://2medical.news/2020/08/19/cms121-a-fatty-acid-synthase-inhibitor-protects-against-excess-lipid-peroxidation-and-inflammation-and-alleviates-cognitive-loss-in-a-transgenic-mouse-model-of-alzheimers-disease/
The oxidative degradation of lipids has been shown to be implicated in the progression of several neurodegenerative diseases and modulating lipid peroxidation may be efficacious for treating Alzheimer’s disease (AD). This hypothesis is strengthened by recent findings suggesting that oxytosis/ferroptosis, a cell death process characterized by increased lipid peroxidation, plays an important role in AD-related toxicities. CMS121 is a small molecule developed against these aspects …
#Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
https://2medical.news/2021/01/11/depression-and-increased-risk-of-alzheimers-dementia-longitudinal-analyses-of-modifiable-risk-and-sex-related-factors/
Highlights •We investigated whether recent and/or remote depression was associated with increased risk of Alzheimer’s Dementia (AD) and whether this risk differed between men and women. •Recent depression was independently associated with increased risk of incident AD while remote depression was not. Recent depression was predictive of AD development in females, but not in males, while sex did not moderate recent depression-associated risk of developing …
https://2medical.news/2021/01/11/depression-and-increased-risk-of-alzheimers-dementia-longitudinal-analyses-of-modifiable-risk-and-sex-related-factors/
Highlights •We investigated whether recent and/or remote depression was associated with increased risk of Alzheimer’s Dementia (AD) and whether this risk differed between men and women. •Recent depression was independently associated with increased risk of incident AD while remote depression was not. Recent depression was predictive of AD development in females, but not in males, while sex did not moderate recent depression-associated risk of developing …
#Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease
https://2medical.news/2021/02/22/physical-activity-may-not-be-associated-with-long%E2%80%90term-risk-of-dementia-and-alzheimers-disease/
While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer’s disease (AD). Material and methods We analysed data on 2394 apparently healthy men with good baseline …
https://2medical.news/2021/02/22/physical-activity-may-not-be-associated-with-long%E2%80%90term-risk-of-dementia-and-alzheimers-disease/
While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer’s disease (AD). Material and methods We analysed data on 2394 apparently healthy men with good baseline …
Clinical and Biological Correlates of White Matter Hyperintensities in Patients with #Behavioral-variant Frontotemporal #Dementia and #Alzheimer Disease
https://2medical.news/2021/02/27/clinical-and-biological-correlates-of-white-matter-hyperintensities-in-patients-with-behavioral-variant-frontotemporal-dementia-and-alzheimer-disease/
To test the hypothesis that white matter hyperintensities (WMH) in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD) are associated with disease variables such as disease severity, cortical atrophy and cognition, we conducted a cross-sectional brain MRI study with volumetric and voxel-wise analyses. Methods: 129 patients (64 bvFTD, 65 AD) and 66 controls underwent high-resolution brain MRI, clinical and neuropsychological examination. Genetic screening was conducted …
https://2medical.news/2021/02/27/clinical-and-biological-correlates-of-white-matter-hyperintensities-in-patients-with-behavioral-variant-frontotemporal-dementia-and-alzheimer-disease/
To test the hypothesis that white matter hyperintensities (WMH) in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD) are associated with disease variables such as disease severity, cortical atrophy and cognition, we conducted a cross-sectional brain MRI study with volumetric and voxel-wise analyses. Methods: 129 patients (64 bvFTD, 65 AD) and 66 controls underwent high-resolution brain MRI, clinical and neuropsychological examination. Genetic screening was conducted …
Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study
https://2medical.news/2021/05/07/low-doses-of-ionizing-radiation-as-a-treatment-for-alzheimers-disease-a-pilot-study/
https://2medical.news/2021/05/07/low-doses-of-ionizing-radiation-as-a-treatment-for-alzheimers-disease-a-pilot-study/
2Medical.News
Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study
In 2015, a patient in hospice with Alzheimer’s disease (AD) was treated with ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech, movement, and appetite was ob…
#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
https://2medical.news/2021/05/10/mediterranean-diet-alzheimer-disease-biomarkers-and-brain-atrophy-in-old-age/
https://2medical.news/2021/05/10/mediterranean-diet-alzheimer-disease-biomarkers-and-brain-atrophy-in-old-age/
2Medical.News
#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age
To determine if following a Mediterranean-like diet (MeDi) relates to cognitive functions and in vivo biomarkers for Alzheimer’s disease (AD), we analyzed cross-sectional data from the German Longi…