Association between Neu5Gc carbohydrate and serum antibodies against it provides the molecular link to #cancer: French NutriNet-Santé study
https://2medical.news/2020/11/03/association-between-neu5gc-carbohydrate-and-serum-antibodies-against-it-provides-the-molecular-link-to-cancer-french-nutrinet-sante-study/
High consumption of red and processed meat is commonly associated with increased cancer risk, particularly colorectal cancer. Antibodies against the red meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate cancer in “human-like” mice. Human anti-Neu5Gc IgG and red meat are both independently proposed to increase cancer risk, yet how diet affects these antibodies is largely unknown.. ..We found that high-Neu5Gc diet, gender, and age affect the specificity, …
https://2medical.news/2020/11/03/association-between-neu5gc-carbohydrate-and-serum-antibodies-against-it-provides-the-molecular-link-to-cancer-french-nutrinet-sante-study/
High consumption of red and processed meat is commonly associated with increased cancer risk, particularly colorectal cancer. Antibodies against the red meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate cancer in “human-like” mice. Human anti-Neu5Gc IgG and red meat are both independently proposed to increase cancer risk, yet how diet affects these antibodies is largely unknown.. ..We found that high-Neu5Gc diet, gender, and age affect the specificity, …
Predicted #Heart Age Among #Cancer Survivors
https://2medical.news/2021/01/10/predicted-heart-age-among-cancer-survivors/
What is already known about this topic? Cancer and cardiovascular disease (CVD) share long-term risk factors. Physician-patient communication using heart age has been effective in motivating patients to improve modifiable CVD risk factors. What is added by this report? The predicted heart age and excess heart age among cancer survivors were 57.2 and 8.5 years, respectively, for men and 54.8 and 6.5 years, respectively, for …
https://2medical.news/2021/01/10/predicted-heart-age-among-cancer-survivors/
What is already known about this topic? Cancer and cardiovascular disease (CVD) share long-term risk factors. Physician-patient communication using heart age has been effective in motivating patients to improve modifiable CVD risk factors. What is added by this report? The predicted heart age and excess heart age among cancer survivors were 57.2 and 8.5 years, respectively, for men and 54.8 and 6.5 years, respectively, for …
#Cancer Statistics, 2021
https://2medical.news/2021/01/15/cancer-statistics-2021/
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population‐based cancer occurrence. Incidence data (through 2017) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2018) were collected by …
https://2medical.news/2021/01/15/cancer-statistics-2021/
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths in the United States and compiles the most recent data on population‐based cancer occurrence. Incidence data (through 2017) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2018) were collected by …
Drug-specific and dosage effects of #statins and the risk of #cancer: a population-based cohort study in South Korea
https://2medical.news/2021/02/08/drug-specific-and-dosage-effects-of-statins-and-the-risk-of-cancer-a-population-based-cohort-study-in-south-korea/
This study aimed to investigate whether the drug-specific and dosage effects of statin use were associated with a lower risk of cancer in adults in South Korea. We evaluated the adult population registered in the 2010 sample cohort database of South Korea. Subjects were divided into the statin group (those who had been prescribed continuous oral statin over 1 year) and the control group (those …
https://2medical.news/2021/02/08/drug-specific-and-dosage-effects-of-statins-and-the-risk-of-cancer-a-population-based-cohort-study-in-south-korea/
This study aimed to investigate whether the drug-specific and dosage effects of statin use were associated with a lower risk of cancer in adults in South Korea. We evaluated the adult population registered in the 2010 sample cohort database of South Korea. Subjects were divided into the statin group (those who had been prescribed continuous oral statin over 1 year) and the control group (those …
Calculated indices of volatile organic compounds (VOCs) in exhalation for #lung #cancer screening and early detection
https://2medical.news/2021/02/17/calculated-indices-of-volatile-organic-compounds-vocs-in-exhalation-for-lung-cancer-screening-and-early-detection/
Breath analysis is a promising noninvasive technique that offers a wide range of opportunities to facilitate early diagnosis of lung cancer (LC). Method Exhaled breath samples of 352 subjects including 160 with lung cancer (LC), 70 with benign pulmonary nodule (BPN) and 122 healthy controls (HC) were analyzed through thermal desorption coupled with gas chromatography-mass spectrometry (TD-GC–MS) to obtain the metabolic information from volatile organic …
https://2medical.news/2021/02/17/calculated-indices-of-volatile-organic-compounds-vocs-in-exhalation-for-lung-cancer-screening-and-early-detection/
Breath analysis is a promising noninvasive technique that offers a wide range of opportunities to facilitate early diagnosis of lung cancer (LC). Method Exhaled breath samples of 352 subjects including 160 with lung cancer (LC), 70 with benign pulmonary nodule (BPN) and 122 healthy controls (HC) were analyzed through thermal desorption coupled with gas chromatography-mass spectrometry (TD-GC–MS) to obtain the metabolic information from volatile organic …
American Society of Hematology 2021 guidelines for management of venous #thromboembolism: prevention and treatment in patients with #cancer
https://2medical.news/2021/03/05/american-society-of-hematology-2021-guidelines-for-management-of-venous-thromboembolism-prevention-and-treatment-in-patients-with-cancer/
Venous thromboembolism (VTE) is a common complication among patients with cancer. Patients with cancer and VTE are at a markedly increased risk for morbidity and mortality. Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in their decisions about the prevention and treatment of VTE in patients with cancer. Methods: ASH formed …
https://2medical.news/2021/03/05/american-society-of-hematology-2021-guidelines-for-management-of-venous-thromboembolism-prevention-and-treatment-in-patients-with-cancer/
Venous thromboembolism (VTE) is a common complication among patients with cancer. Patients with cancer and VTE are at a markedly increased risk for morbidity and mortality. Objective: These evidence-based guidelines of the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in their decisions about the prevention and treatment of VTE in patients with cancer. Methods: ASH formed …
Broadened Eligibility for #Lung #Cancer Screening Challenges and Uncertainty for Implementation and Equity
https://2medical.news/2021/03/10/broadened-eligibility-for-lung-cancer-screening-challenges-and-uncertainty-for-implementation-and-equity/
In 2013, the US Preventive Services Task Force (USPSTF) recommended annual lung cancer screening with low-dose computed tomography (CT) in US adults aged 55 to 80 years who currently smoke or formerly smoked with a 30 pack-year history, and for those who formerly smoked, quitting within the past 15 years (grade “B” recommendation).1 In this issue of JAMA, the USPSTF updates this recommendation, proposing 2 …
https://2medical.news/2021/03/10/broadened-eligibility-for-lung-cancer-screening-challenges-and-uncertainty-for-implementation-and-equity/
In 2013, the US Preventive Services Task Force (USPSTF) recommended annual lung cancer screening with low-dose computed tomography (CT) in US adults aged 55 to 80 years who currently smoke or formerly smoked with a 30 pack-year history, and for those who formerly smoked, quitting within the past 15 years (grade “B” recommendation).1 In this issue of JAMA, the USPSTF updates this recommendation, proposing 2 …
ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
https://2medical.news/2021/03/12/acg-clinical-guidelines-colorectal-cancer-screening-2021/
1. We recommend CRC screening in average-risk individuals between ages 50 and 75 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Strong recommendation; moderate-quality evidence 2. We suggest CRC screening in average-risk individuals between ages 45 and 49 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Conditional recommendation; very low-quality evidence 3. We suggest that a decision …
https://2medical.news/2021/03/12/acg-clinical-guidelines-colorectal-cancer-screening-2021/
1. We recommend CRC screening in average-risk individuals between ages 50 and 75 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Strong recommendation; moderate-quality evidence 2. We suggest CRC screening in average-risk individuals between ages 45 and 49 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Conditional recommendation; very low-quality evidence 3. We suggest that a decision …
Effectiveness of Electroacupuncture or Auricular #Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among #Cancer Survivors The PEACE Randomized Clinical Trial
https://2medical.news/2021/03/20/effectiveness-of-electroacupuncture-or-auricular-acupuncture-vs-usual-care-for-chronic-musculoskeletal-pain-among-cancer-survivors-the-peace-randomized-clinical-trial/
The opioid crisis creates challenges for cancer pain management. Acupuncture confers clinical benefits for chronic nonmalignant pain, but its effectiveness in cancer survivors remains uncertain. Objective To determine the effectiveness of electroacupuncture or auricular acupuncture for chronic musculoskeletal pain in cancer survivors. Design, Setting, and Participants The Personalized Electroacupuncture vs Auricular Acupuncture Comparativeness Effectiveness (PEACE) trial is a randomized clinical trial that was conducted from …
https://2medical.news/2021/03/20/effectiveness-of-electroacupuncture-or-auricular-acupuncture-vs-usual-care-for-chronic-musculoskeletal-pain-among-cancer-survivors-the-peace-randomized-clinical-trial/
The opioid crisis creates challenges for cancer pain management. Acupuncture confers clinical benefits for chronic nonmalignant pain, but its effectiveness in cancer survivors remains uncertain. Objective To determine the effectiveness of electroacupuncture or auricular acupuncture for chronic musculoskeletal pain in cancer survivors. Design, Setting, and Participants The Personalized Electroacupuncture vs Auricular Acupuncture Comparativeness Effectiveness (PEACE) trial is a randomized clinical trial that was conducted from …
Therapeutic Repurposing of #Biguanides in #Cancer
https://2medical.news/2021/04/21/therapeutic-repurposing-of-biguanides-in-cancer/
Biguanides exert antitumor activities through various biochemical mechanisms involving mitochondrial complex I, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and/or mitochondrial glycerophosphate dehydrogenase (mGPD). Biguanides selectively target subpopulations of cancer cells addicted to oxidative phosphorylation (OXPHOS). Metabolic adaptations triggered by biguanide exposure could be potential targets to improve the antitumor efficacy of biguanides. Biguanides modulate antitumor immunity by targeting immune cells in the …
https://2medical.news/2021/04/21/therapeutic-repurposing-of-biguanides-in-cancer/
Biguanides exert antitumor activities through various biochemical mechanisms involving mitochondrial complex I, AMP-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and/or mitochondrial glycerophosphate dehydrogenase (mGPD). Biguanides selectively target subpopulations of cancer cells addicted to oxidative phosphorylation (OXPHOS). Metabolic adaptations triggered by biguanide exposure could be potential targets to improve the antitumor efficacy of biguanides. Biguanides modulate antitumor immunity by targeting immune cells in the …