#consanguineous marriages(9.3)
#Endogamy(caste)
#Mendelian laws of Inheritance (Recessive alleles)
✅ Study by:
The large-scale genetic study was conducted by two key research groups. Kumarasamy Thangaraj's group at the Centre for Cellular and Molecular Biology in Hyderabad identified a specific genetic deletion linked to cardiac failure. Jeffrey Wall and colleagues at the University of California further extended this research to examine genetic diversity and patterns across South Asia.
✅ Objective:
The main goal of the research was to explore the unique genetic aspects of South Asia, with a particular focus on the Indian population. The study aimed to understand how genetic differences and cultural practices like endogamy could impact health and disease prevalence in the region.
✅ Method used:
The methodology involved two significant phases:
Thangaraj's group identified a unique 25-base-pair deletion in the DNA, dating around 30,000 years ago, affecting the Indian population.
Jeffrey Wall's team collected DNA from 5,000 individuals across India, Pakistan, Bangladesh, and other South-Asian communities. They employed whole-genome sequencing and unbiased computational approaches to detect genetic differences and evaluate the influence of endogamous practices on genetic diversity.
✅ Result:
The studies revealed stark genetic differences within the subcontinent and emphasized the role of endogamous practices in conserving genetic patterns. There was little genetic mixing between communities, leading to a higher frequency of homozygous genotypes, especially in South-Indian and Pakistani subgroups. This could increase the risk of major disorders like cardiovascular diseases, diabetes, cancers, and mental disorders.
✅ Limitations:
A significant limitation of the research was that the cohort was recruited from hospitals and healthcare providers, possibly biasing the genomes studied towards individuals seeking medical intervention. This may not represent the full diversity of the subcontinent's population.
✅ Conclusion:
There is necessity of more detailed studies of the Indian genome within the country to reflect India's incredible genetic diversity and safeguard vulnerable communities. A call is made for the development of competence and infrastructure for such research within the nation. The potential to identify unique genetic variants for interventions against major health concerns is acknowledged, reflecting an ambitious outlook to harness genetic studies for national well-being. The progression from genetics used for European royal lineage to understanding complex medical disorders within the Indian context is also emphasized.
For more : CLICK HERE
#Endogamy(caste)
#Mendelian laws of Inheritance (Recessive alleles)
✅ Study by:
The large-scale genetic study was conducted by two key research groups. Kumarasamy Thangaraj's group at the Centre for Cellular and Molecular Biology in Hyderabad identified a specific genetic deletion linked to cardiac failure. Jeffrey Wall and colleagues at the University of California further extended this research to examine genetic diversity and patterns across South Asia.
✅ Objective:
The main goal of the research was to explore the unique genetic aspects of South Asia, with a particular focus on the Indian population. The study aimed to understand how genetic differences and cultural practices like endogamy could impact health and disease prevalence in the region.
✅ Method used:
The methodology involved two significant phases:
Thangaraj's group identified a unique 25-base-pair deletion in the DNA, dating around 30,000 years ago, affecting the Indian population.
Jeffrey Wall's team collected DNA from 5,000 individuals across India, Pakistan, Bangladesh, and other South-Asian communities. They employed whole-genome sequencing and unbiased computational approaches to detect genetic differences and evaluate the influence of endogamous practices on genetic diversity.
✅ Result:
The studies revealed stark genetic differences within the subcontinent and emphasized the role of endogamous practices in conserving genetic patterns. There was little genetic mixing between communities, leading to a higher frequency of homozygous genotypes, especially in South-Indian and Pakistani subgroups. This could increase the risk of major disorders like cardiovascular diseases, diabetes, cancers, and mental disorders.
✅ Limitations:
A significant limitation of the research was that the cohort was recruited from hospitals and healthcare providers, possibly biasing the genomes studied towards individuals seeking medical intervention. This may not represent the full diversity of the subcontinent's population.
✅ Conclusion:
There is necessity of more detailed studies of the Indian genome within the country to reflect India's incredible genetic diversity and safeguard vulnerable communities. A call is made for the development of competence and infrastructure for such research within the nation. The potential to identify unique genetic variants for interventions against major health concerns is acknowledged, reflecting an ambitious outlook to harness genetic studies for national well-being. The progression from genetics used for European royal lineage to understanding complex medical disorders within the Indian context is also emphasized.
For more : CLICK HERE
Telegram
Anthropology by Shiva Teja (ACE WITH EASE IAS)
Anthropology faculty at ACE WITH EASE IAS.Author of SUNYA
ANTHROPOLOGY BOOKS.
Let’s simplify Anthropology to the core ✍️☑️
www.acewithease.com
ANTHROPOLOGY BOOKS.
Let’s simplify Anthropology to the core ✍️☑️
www.acewithease.com
✅️️Relevance - Interlinking to various topics
( socio cultural and Physical Anthropology )
Exploring the Genetic Implications of Endogamy:
Insights from CCMB Research
🧬 Genetic Challenges in Endogamous Marriages Recent research from the Centre for Cellular and Molecular Biology (CCMB) reveals startling connections between endogamous marriage practices and increased health risks. Predominantly seen in young populations, endogamy can amplify the presence of recessive lethal and sub-lethal genes, leading to higher incidences of cardiac failures.
🔍 Specific Genetic Findings
A key genetic marker identified is a 25-base pair deletion in the MYBPC3 gene, particularly prevalent in South India. This mutation is notably associated with cardiac diseases and is present in about 4% of the Indian population. The research highlights that South Indian and Pakistani sub-groups exhibit a higher frequency of homozygous genotypes, intensifying the risk.
🌍 Global Context and the Indian Genome Studies
This research is part of a broader effort under the Indian Genome Project, aiming to map genetic diversity and understand the genetic architecture of the Indian population. It underscores the critical need for genetic diversity and the potential risks of restricted gene pools due to social practices like endogamy.
Implications for Policy and Public Health
These findings are vital for public health strategies and policy-making, providing a genetic lens to view the impacts of cultural practices like endogamy. They stress the importance of genetic counseling and community awareness programs to mitigate health risks associated with genetic disorders.
🧐 Why This Matters?
Highlighting these genetic insights in discussions about marriage, endogamy, and genetic diversity not only enhances contemporary relevance but also fosters a better understanding of how cultural practices can intersect with and influence health outcomes.
#Marriage #Endogamy #Genetic #LethalGenes #GeneticDiversity #GenomeProject #IndianGenomeStudies
( socio cultural and Physical Anthropology )
Exploring the Genetic Implications of Endogamy:
Insights from CCMB Research
🧬 Genetic Challenges in Endogamous Marriages Recent research from the Centre for Cellular and Molecular Biology (CCMB) reveals startling connections between endogamous marriage practices and increased health risks. Predominantly seen in young populations, endogamy can amplify the presence of recessive lethal and sub-lethal genes, leading to higher incidences of cardiac failures.
🔍 Specific Genetic Findings
A key genetic marker identified is a 25-base pair deletion in the MYBPC3 gene, particularly prevalent in South India. This mutation is notably associated with cardiac diseases and is present in about 4% of the Indian population. The research highlights that South Indian and Pakistani sub-groups exhibit a higher frequency of homozygous genotypes, intensifying the risk.
🌍 Global Context and the Indian Genome Studies
This research is part of a broader effort under the Indian Genome Project, aiming to map genetic diversity and understand the genetic architecture of the Indian population. It underscores the critical need for genetic diversity and the potential risks of restricted gene pools due to social practices like endogamy.
Implications for Policy and Public Health
These findings are vital for public health strategies and policy-making, providing a genetic lens to view the impacts of cultural practices like endogamy. They stress the importance of genetic counseling and community awareness programs to mitigate health risks associated with genetic disorders.
🧐 Why This Matters?
Highlighting these genetic insights in discussions about marriage, endogamy, and genetic diversity not only enhances contemporary relevance but also fosters a better understanding of how cultural practices can intersect with and influence health outcomes.
#Marriage #Endogamy #Genetic #LethalGenes #GeneticDiversity #GenomeProject #IndianGenomeStudies