ARE WE STARTING TO SEE A.D.E.? Supporting source #3:

Pfizer says immunity can drop to 83% within four months in people who got its COVID-19 shot, further bolstering the company case for a booster
Last Updated: Aug. 5, 2021

The effectiveness of Pfizer’s COVID-19 shot can drop to 83.7% within four to six months after getting the second dose of its vaccine. This is the latest indication that vaccine-induced immunity to the virus can wane and some kind of boost may be necessary in the future.

New research published Wednesday as a preprint indicates that the Pfizer Inc. PFE, +0.34% shot provides 96.2% protection for the first two months, 90.1% effectiveness between the second and fourth months, and 83.7% of protection for the fourth, fifth, and six months.

“We will need a booster eight to 12 months from the second dose,” Pfizer CEO Albert Bourla said Wednesday, according to a FactSet transcript of the company’s second-quarter earnings call.

The drug maker has been making the case for booster shots, citing limited data from its own clinical research and real-world data out of Israel, where Pfizer’s vaccine is the predominant shot in circulation....

www.marketwatch.com/story/pfizer-says-immunity-drops-to-83-within-six-months-in-people-who-got-its-covid-19-shot-further-bolstering-the-company-case-for-a-booster-11627579817

#covid19 #ADE #vaccine_failure #HighWire

ARE WE STARTING TO SEE A.D.E.? Supporting source #4:

Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?
Nouara Yahi, Henri Chahinian, Jacques Fantini

Abstract
Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :4203-4219, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modeling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors). Under these circumstances, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.

https://pubmed.ncbi.nlm.nih.gov/34384810/

#covid19 #ADE #vaccine_failure #HighWire

ARE WE STARTING TO SEE A.D.E.? Supporting source #5:

UK scientists back Covid boosters as study finds post-jab falls in antibodies
Exclusive: Waning antibody levels are possible warning sign of lower protection in months after vaccination

The UCL Virus Watch study found that antibodies generated by two doses of the Oxford/AstraZeneca and Pfizer/BioNTech vaccines started to wane as early as six weeks after the second shot, in some cases falling more than 50% over 10 weeks.

https://www.theguardian.com/world/2021/jul/22/uk-scientists-back-covid-boosters-as-study-finds-post-jab-falls-in-antibodies

#covid19 #ADE #vaccine_failure #HighWire

ARE WE STARTING TO SEE A.D.E.? Supporting source #6:

Israel says Pfizer Covid vaccine is just 39% effective as delta spreads, but still prevents severe illness
JUL 23 2021

https://www.cnbc.com/2021/07/23/delta-variant-pfizer-covid-vaccine-39percent-effective-in-israel-prevents-severe-illness.html

#covid19 #ADE #vaccine_failure #HighWire

ARE WE STARTING TO SEE A.D.E.? Supporting source #7:

Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections
Sivan Gazit, Roei Shlezinger, Galit Perez, Roni Lotan, Asaf Peretz, Amir Ben-Tov, Dani Cohen, Khitam Muhsen, Gabriel Chodick, Tal Patalon

Results
SARS-CoV-2-naïve vaccinees had a 13.06-fold (95% CI, 8.08 to 21.11) increased risk for breakthrough infection with the Delta variant compared to those previously infected, when the first event (infection or vaccination) occurred during January and February of 2021. The increased risk was significant (P<0.001) for symptomatic disease as well. When allowing the infection to occur at any time before vaccination (from March 2020 to February 2021), evidence of waning natural immunity was demonstrated, though SARS-CoV-2 naïve vaccinees had a 5.96-fold (95% CI, 4.85 to 7.33) increased risk for breakthrough infection and a 7.13-fold (95% CI, 5.51 to 9.21) increased risk for symptomatic disease. SARS-CoV-2-naïve vaccinees were also at a greater risk for COVID-19-related-hospitalizations compared to those that were previously infected.

https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v1.full

#covid19 #ADE #vaccine_failure #HighWire

ARE WE STARTING TO SEE A.D.E.? Supporting source #8:

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier
Tetyana P. Buzhdygan, Brandon J. DeOre, Abigail Baldwin-Leclair, Trent A. Bullock, Hannah M. McGary, Jana A. Khan, Roshanak Razmpour, Jonathan F. Hale, Peter A. Galie, Raghava Potula, Allison M. Andrews, and Servio H. Ramireza

Abstract
As researchers across the globe have focused their attention on understanding SARS-CoV-2, the picture that is emerging is that of a virus that has serious effects on the vasculature in multiple organ systems including the cerebral vasculature. Observed effects on the central nervous system include neurological symptoms (headache, nausea, dizziness), fatal microclot formation and in rare cases encephalitis. However, our understanding of how the virus causes these mild to severe neurological symptoms and how the cerebral vasculature is impacted remains unclear. Thus, the results presented in this report explored whether deleterious outcomes from the SARS-CoV-2 viral spike protein on primary human brain microvascular endothelial cells (hBMVECs) could be observed. The spike protein, which plays a key role in receptor recognition, is formed by the S1 subunit containing a receptor binding domain (RBD) and the S2 subunit. First, using postmortem brain tissue, we show that the angiotensin converting enzyme 2 or ACE2 (a known binding target for the SARS-CoV-2 spike protein), is ubiquitously expressed throughout various vessel calibers in the frontal cortex. Moreover, ACE2 expression was upregulated in cases of hypertension and dementia. ACE2 was also detectable in primary hBMVECs maintained under cell culture conditions. Analysis of cell viability revealed that neither the S1, S2 or a truncated form of the S1 containing only the RBD had minimal effects on hBMVEC viability within a 48 h exposure window. Introduction of spike proteins to invitro models of the blood-brain barrier (BBB) showed significant changes to barrier properties. Key to our findings is the demonstration that S1 promotes loss of barrier integrity in an advanced 3D microfluidic model of the human BBB, a platform that more closely resembles the physiological conditions at this CNS interface. Evidence provided suggests that the SARS-CoV-2 spike proteins trigger a pro-inflammatory response on brain endothelial cells that may contribute to an altered state of BBB function. Together, these results are the first to show the direct impact that the SARS-CoV-2 spike protein could have on brain endothelial cells; thereby offering a plausible explanation for the neurological consequences seen in COVID-19 patients.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7547916/

#covid19 #ADE #vaccine_failure #HighWire

ARE WE STARTING TO SEE A.D.E.? Supporting source #9:

SARS-CoV-2 spike proteins disrupt the blood-brain barrier, new research shows
Potentially raising risk of neurological damage in COVID-19 patients
Date: October 29, 2020

The researchers then investigated the effects of the SARS-CoV-2 spike protein on brain endothelial cells in cell culture models. Introduction of the spike protein, particularly a portion designated subunit 1, produced substantial changes in endothelial barrier function that led to declines in barrier integrity. The researchers also uncovered evidence that subunit 2 of the SARS-CoV-2 spike protein can directly impact blood-brain barrier function. "This is of importance because unlike subunit 1, subunit 2 of the spike protein doesn't bind to ACE2, meaning that a breach to the blood-brain barrier could occur in a manner that is independent of ACE2," explained postdoctoral fellow and first author on the new report Tetyana P. Buzhdygan, PhD.

https://www.sciencedaily.com/releases/2020/10/201029141941.htm

#covid19 #ADE #vaccine_failure #HighWire

ARE WE STARTING TO SEE A.D.E.? Supporting source #10 of 10—final in the series:

Intravenous injection of COVID-19 mRNA vaccine can induce acute myopericarditis in mouse model
Can Li, Yanxia Chen, Yan Zhao, David Christopher Lung, Zhanhong Ye, Wenchen Song, Fei-Fei Liu, Jian-Piao Cai, Wan-Man Wong, Cyril Chik-Yan Yip....

Post-vaccination myopericarditis is reported after immunization with COVID-19 mRNA-vaccines. The effect of accidental intravenous injection of this vaccine on the heart is unknown.

https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab707/6353927

#covid19 #ADE #vaccine_failure #HighWire

VACCINE FAILURE IN QUEBEC:

Elderly resident centres were the first to be fully vaccinated in Quebec, as a priority group. Now we have a report of the second nursing home in two weeks to be experiencing Covid infections. No comment, no apologies from the propaganda media, even as they continue to tout the injectables.

https://montreal.ctvnews.ca/covid-19-outbreak-at-a-long-term-care-home-in-mirabel-1.5603838

#covid19 #Quebec #Canada #vaccine_failure #nursing_homes

How Fauci Fooled America
By MARTIN KULLDORFF AND JAY BHATTACHARYA
Newsweek, Nov. 1, 2021

EXTRACTS:

Natural immunity. By pushing vaccine mandates, Dr. Fauci ignores naturally acquired immunity among the COVID-recovered, of which there are more than 45 million in the United States. Mounting evidence indicates that natural immunity is stronger and longer lasting than vaccine-induced immunity. In a study from Israel, the vaccinated were 27 times more likely to get symptomatic COVID than the unvaccinated who had recovered from a prior infection....

Protecting the elderly. While anyone can get infected, there is more than a thousand-fold difference in mortality risk between the old and the young. After more than 700,000 reported COVID deaths in America, we now know that lockdowns failed to protect high-risk older people. When confronted with the idea of focused protection of the vulnerable, Dr. Fauci admitted he had no idea how to accomplish it, arguing that it would be impossible. That may be understandable for a lab scientist, but public health scientists have presented many concrete suggestions that would have helped, had Fauci and other officials not ignored them....

School closures. Schools are major transmission points for influenza, but not for COVID. While children do get infected, their risk for COVID death is minuscule, lower than their already low risk of dying from the flu. Throughout the 2020 spring wave, Sweden kept daycare and schools open for all its 1.8 million children ages 1 to 15, with no masks, testing or social distancing. The result? Zero COVID deaths among children and a COVID risk to teachers lower than the average of other professions. In fall 2020, most European countries followed suit, with similar results. Considering the devastating effects of school closures on children, Dr. Fauci's advocacy for school closures may be the single biggest mistake of his career....

Masks. The gold standard of medical research is randomized trials, and there have now been two on COVID masks for adults. For children, there is no solid scientific evidence that masks work. A Danish study found no statistically significant difference between masking and not masking when it came to coronavirus infection. In a study in Bangladesh, the 95 percent confidence interval showed that masks reduced transmission between 0 percent and 18 percent. Hence, masks are either of zero or limited benefit. There are many more critical pandemic measures that Dr. Fauci could have emphasized, such as better ventilation in schools and hiring nursing home staff with natural immunity....

CONTINUE HERE:
https://www.newsweek.com/how-fauci-fooled-america-opinion-1643839

#covid19 #Fauci #NIH #natural_immunity #vaccine_failure #masks #school_closures #children

Spike-Only Vaccine a Colossal Blunder: Michigan State University Shows SARS-CoV-2 Vaccine Escape is Due to Vaccination
Earlier analyses had shown correlation of new COVID-19 cases with vaccine uptake, indicating vaccine escape. Now that causality is confirmed, the question is: Will policy makers stop making it worse?

EXTRACT:
Yesterday, I published a mathematical analysis that showed that the Barnstable County, Massachusetts (CDC data) supports the conclusion of negative efficacy (vaccinated people more likely to be diagnosed with COVID-19). Earlier, I had published and announced in a public speech (Harrisburg) that the vaccine program had failed, in part based on my findings that the number of new cases was highest in countries with highest vaccine uptake (See article here). The Israeli and UK data showed more cases in the vaccinated than in the unvaccinated, and my analysis yesterday should silence the pedestrian response “that’s because there are more people who are vaccinated”. I’ve pointed out (as have others) that Fauci’s “go home until you are sick enough to need emergency care” makes people variant incubators.

Now a new study has found the specific mutations by which the SARS-CoV-2 lineages have escaped the vaccine. The study, which is behind a paywall (US$40), reports that these mutations lead to less infectivity compared to the original SARS-CoV-2, but, according to the authors, “can disrupt existing antibodies that neutralize the virus”.

That sounds like disease enhancement to me.

“By tracking the evolutionary trajectories of vax-resistant mutations in more than 2.2 million SARS-CoV-2 genomes, we reveal that the occurrence & frequency of vax-resistant mutations correlate strongly with the vaccination rates in Europe and America.”

Their analysis went well beyond mere correlation of the rise of the vaccine-resistant variants and vaccination rates. Specifically, these authors had previously predicted the precise amino acid location in the receptor binding domain (RBD) at which vaccine escape variation would likely emerge as a result of targeting the spike protein with vaccines. Now that we see those specific amino acid residue positions changing, and, importantly, changing in ways that alter infectivity, the evidence is strong that the rise in these mutations was caused by the vaccination program.

CONTINUE HERE:
https://popularrationalism.substack.com/p/spike-only-vaccine-a-colossal-blunder

#covid19 #vaccine_failure #Omicron