#Urate Lowering Therapy in Moderate to Severe Chronic #Kidney Disease
http://acrabstracts.org/abstract/urate-lowering-therapy-in-moderate-to-severe-chronic-kidney-disease/
Conclusion: This study suggests that patients who achieve ACR Goal of sUA of <6mg/dl on ULT have higher rates of eGFR improvement (≥ 30% improvement). This effect is seen across the CKD spectrum from Stage 2 through Stage 4 with the most pronounced effect in CKD 3 patients.
http://acrabstracts.org/abstract/urate-lowering-therapy-in-moderate-to-severe-chronic-kidney-disease/
Conclusion: This study suggests that patients who achieve ACR Goal of sUA of <6mg/dl on ULT have higher rates of eGFR improvement (≥ 30% improvement). This effect is seen across the CKD spectrum from Stage 2 through Stage 4 with the most pronounced effect in CKD 3 patients.
ACR Meeting Abstracts
Urate Lowering Therapy in Moderate to Severe Chronic Kidney Disease - ACR Meeting Abstracts
Urate Lowering Therapy in Moderate to Severe Chronic Kidney Disease Levy G, Cheetham C, Shi J, Rashid N Background/Purpose: To determine if urate lowering therapy (ULT) can improve Chronic Kidney Disease (CKD) function when patients achieve a serum uric…
Relationship between serum #urate concentration and clinically evident incident #gout: an individual participant data analysis
http://ard.bmj.com/content/early/2018/02/28/annrheumdis-2017-212288
This analysis included 18 889 participants who were gout-free at baseline, with mean (SD) 11.2 (4.2) years and 212 363 total patient-years of follow-up. The cumulative incidence at each time point varied according to baseline serum urate concentrations, with 15-year cumulative incidence (95% CI) ranging from 1.1% (0.9 to 1.4) for <6 mg/dL to 49% (31 to 67) for ≥10 mg/dL. Compared with baseline serum urate <6 mg/dL, the adjusted HR for baseline serum urate 6.0–6.9 mg/dL was 2.7, for 7.0–7.9 mg/dL was 6.6, for 8.0–8.9 mg/dL was 15, for 9.0–9.9 mg/dL was 30, and for ≥10 mg/dL was 64.
Conclusions Serum urate level is a strong non-linear concentration-dependent predictor of incident gout. Nonetheless, only about half of those with serum urate concentrations ≥10mg/dL develop clinically evident gout over 15 years, implying a role for prolonged hyperuricaemia and additional factors in the pathogenesis of gout
http://ard.bmj.com/content/early/2018/02/28/annrheumdis-2017-212288
This analysis included 18 889 participants who were gout-free at baseline, with mean (SD) 11.2 (4.2) years and 212 363 total patient-years of follow-up. The cumulative incidence at each time point varied according to baseline serum urate concentrations, with 15-year cumulative incidence (95% CI) ranging from 1.1% (0.9 to 1.4) for <6 mg/dL to 49% (31 to 67) for ≥10 mg/dL. Compared with baseline serum urate <6 mg/dL, the adjusted HR for baseline serum urate 6.0–6.9 mg/dL was 2.7, for 7.0–7.9 mg/dL was 6.6, for 8.0–8.9 mg/dL was 15, for 9.0–9.9 mg/dL was 30, and for ≥10 mg/dL was 64.
Conclusions Serum urate level is a strong non-linear concentration-dependent predictor of incident gout. Nonetheless, only about half of those with serum urate concentrations ≥10mg/dL develop clinically evident gout over 15 years, implying a role for prolonged hyperuricaemia and additional factors in the pathogenesis of gout
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Evaluation of the #diet wide contribution to serum #urate levels: meta-analysis of population based cohorts
https://www.bmj.com/content/363/bmj.k3951
Seven foods were associated with raised serum urate levels (beer, liquor, wine, potato, poultry, soft drinks, and meat (beef, pork, or lamb)) and eight foods were associated with reduced serum urate levels (eggs, peanuts, cold cereal, skim milk, cheese, brown bread, margarine, and non-citrus fruits) in the male, female, or full cohorts. Three diet scores, constructed on the basis of healthy diet guidelines, were inversely associated with serum urate levels and a fourth, data driven diet pattern positively associated with raised serum urate levels, but each explained ≤0.3% of variance in serum urate. In comparison, 23.9% of variance in serum urate levels was explained by common, genome wide single nucleotide variation.
Conclusion In contrast with genetic contributions, diet explains very little variation in serum urate levels in the general population
Evaluation of the #diet wide contribution to serum #urate levels: meta-analysis of population based cohorts
https://www.bmj.com/content/363/bmj.k3951
Seven foods were associated with raised serum urate levels (beer, liquor, wine, potato, poultry, soft drinks, and meat (beef, pork, or lamb)) and eight foods were associated with reduced serum urate levels (eggs, peanuts, cold cereal, skim milk, cheese, brown bread, margarine, and non-citrus fruits) in the male, female, or full cohorts. Three diet scores, constructed on the basis of healthy diet guidelines, were inversely associated with serum urate levels and a fourth, data driven diet pattern positively associated with raised serum urate levels, but each explained ≤0.3% of variance in serum urate. In comparison, 23.9% of variance in serum urate levels was explained by common, genome wide single nucleotide variation.
Conclusion In contrast with genetic contributions, diet explains very little variation in serum urate levels in the general population
The BMJ
Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts
Objective To systematically test dietary components for association with serum urate levels and to evaluate the relative contributions of estimates of diet pattern and inherited genetic variants to population variance in serum urate levels.
Design Meta-analysis…
Design Meta-analysis…
Associations of #BMI and Serum #Urate with Developing #Dementia: A Prospective Cohort Study
https://2medical.news/2020/09/19/associations-of-bmi-and-serum-urate-with-developing-dementia-a-prospective-cohort-study/
Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI confound each other is not well established.. ..During a median of 8.1 years of follow-up, a total of 2138 participants developed dementia. People who were underweight had an increased risk of dementia (hazard ratio [HR] …
https://2medical.news/2020/09/19/associations-of-bmi-and-serum-urate-with-developing-dementia-a-prospective-cohort-study/
Recent studies suggested that higher BMI and serum urate levels were associated with lower risk of developing dementia. However, these reverse relationships remain controversial, and whether serum urate and BMI confound each other is not well established.. ..During a median of 8.1 years of follow-up, a total of 2138 participants developed dementia. People who were underweight had an increased risk of dementia (hazard ratio [HR] …