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#Preterm birth and risk of chronic #kidney disease from childhood into mid-adulthood: national cohort study
https://www.bmj.com/content/365/bmj.l1346
Preterm birth and extremely preterm birth (<28 weeks) were associated with nearly twofold and threefold risks of CKD, respectively, from birth into mid-adulthood (adjusted hazard ratio 1.94, 95% confidence interval 1.74 to 2.16; P<0.001; 3.01, 1.67 to 5.45; P<0.001). An increased risk was observed even among those born at early term (37-38 weeks) (1.30, 1.20 to 1.40; P<0.001). The association between preterm birth and CKD was strongest at ages 0-9 years (5.09, 4.11 to 6.31; P<0.001), then weakened but remained increased at ages 10-19 years (1.97, 1.57 to 2.49; P<0.001) and 20-43 years (1.34, 1.15 to 1.57; P<0.001). These associations affected both males and females and did not seem to be related to shared genetic or environmental factors in families.
Conclusions Preterm and early term birth are strong risk factors for the development of CKD from childhood into mid-adulthood. People born prematurely need long term follow-up for monitoring and preventive actions to preserve renal function across the life course.
#Preterm birth and risk of chronic #kidney disease from childhood into mid-adulthood: national cohort study
https://www.bmj.com/content/365/bmj.l1346
Preterm birth and extremely preterm birth (<28 weeks) were associated with nearly twofold and threefold risks of CKD, respectively, from birth into mid-adulthood (adjusted hazard ratio 1.94, 95% confidence interval 1.74 to 2.16; P<0.001; 3.01, 1.67 to 5.45; P<0.001). An increased risk was observed even among those born at early term (37-38 weeks) (1.30, 1.20 to 1.40; P<0.001). The association between preterm birth and CKD was strongest at ages 0-9 years (5.09, 4.11 to 6.31; P<0.001), then weakened but remained increased at ages 10-19 years (1.97, 1.57 to 2.49; P<0.001) and 20-43 years (1.34, 1.15 to 1.57; P<0.001). These associations affected both males and females and did not seem to be related to shared genetic or environmental factors in families.
Conclusions Preterm and early term birth are strong risk factors for the development of CKD from childhood into mid-adulthood. People born prematurely need long term follow-up for monitoring and preventive actions to preserve renal function across the life course.
Saving Veins, Saving Lives, for Patients With Chronic #Kidney Disease
https://annals.org/aim/article-abstract/2735183/saving-veins-saving-lives-patients-chronic-kidney-disease
Vascular access has long been recognized as the Achilles' heel of the management of patients receiving maintenance hemodialysis. Such patients require cannulation with 15-gauge needles 3 times weekly, blood flows of about 400 mL/min, and treatments of 4 to 5 hours per session. This requires creation of arteriovenous fistulae using native veins or arteriovenous grafts using synthetic vein material. Absent usable vessels or time to surgically create and allow maturation of internal access for dialysis, clinicians use large-bore, dual-lumen, tunneled, cuffed dialysis catheters placed in the internal jugular vein. Robust data show that mortality among patients receiving dialysis with #catheters is about 1.6 to 2.5 times higher than among those with internal access and no catheter. The higher rate of catheter use in U.S. hemodialysis patients likely explains the observed higher mortality compared with that in other countries (1, 2)..
https://annals.org/aim/article-abstract/2735183/saving-veins-saving-lives-patients-chronic-kidney-disease
Vascular access has long been recognized as the Achilles' heel of the management of patients receiving maintenance hemodialysis. Such patients require cannulation with 15-gauge needles 3 times weekly, blood flows of about 400 mL/min, and treatments of 4 to 5 hours per session. This requires creation of arteriovenous fistulae using native veins or arteriovenous grafts using synthetic vein material. Absent usable vessels or time to surgically create and allow maturation of internal access for dialysis, clinicians use large-bore, dual-lumen, tunneled, cuffed dialysis catheters placed in the internal jugular vein. Robust data show that mortality among patients receiving dialysis with #catheters is about 1.6 to 2.5 times higher than among those with internal access and no catheter. The higher rate of catheter use in U.S. hemodialysis patients likely explains the observed higher mortality compared with that in other countries (1, 2)..
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Benefits and Harms of Oral #Anticoagulant Therapy in Chronic #Kidney Disease: A Systematic Review and Meta-analysis
https://annals.org/aim/article-abstract/2738158/benefits-harms-oral-anticoagulant-therapy-chronic-kidney-disease-systematic-review
All but the 8 trials involving patients with ESKD excluded participants with creatinine clearance less than 20 mL/min or estimated glomerular filtration rate less than 15 mL/min/1.73 m2. In AF, compared with VKAs, NOACs reduced risks for stroke or systemic embolism (risk ratio RR, 0.79 95% CI, 0.66 to 0.93; high-certainty evidence) and hemorrhagic stroke (RR, 0.48 CI, 0.30 to 0.76; moderate-certainty evidence). Compared with VKAs, the effects of NOACs on recurrent VTE or VTE-related death were uncertain (RR, 0.72 CI, 0.44 to 1.17; low-certainty evidence). In all trials combined, NOACs seemingly reduced major bleeding risk compared with VKAs (RR, 0.75 CI, 0.56 to 1.01; low-certainty evidence).
Conclusion:
In early-stage CKD, NOACs had a benefit–risk profile superior to that of VKAs. For advanced CKD or ESKD, there was insufficient evidence to establish benefits or harms of VKAs or NOACs.
Benefits and Harms of Oral #Anticoagulant Therapy in Chronic #Kidney Disease: A Systematic Review and Meta-analysis
https://annals.org/aim/article-abstract/2738158/benefits-harms-oral-anticoagulant-therapy-chronic-kidney-disease-systematic-review
All but the 8 trials involving patients with ESKD excluded participants with creatinine clearance less than 20 mL/min or estimated glomerular filtration rate less than 15 mL/min/1.73 m2. In AF, compared with VKAs, NOACs reduced risks for stroke or systemic embolism (risk ratio RR, 0.79 95% CI, 0.66 to 0.93; high-certainty evidence) and hemorrhagic stroke (RR, 0.48 CI, 0.30 to 0.76; moderate-certainty evidence). Compared with VKAs, the effects of NOACs on recurrent VTE or VTE-related death were uncertain (RR, 0.72 CI, 0.44 to 1.17; low-certainty evidence). In all trials combined, NOACs seemingly reduced major bleeding risk compared with VKAs (RR, 0.75 CI, 0.56 to 1.01; low-certainty evidence).
Conclusion:
In early-stage CKD, NOACs had a benefit–risk profile superior to that of VKAs. For advanced CKD or ESKD, there was insufficient evidence to establish benefits or harms of VKAs or NOACs.
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Acute #Kidney Injury Among Older Patients Undergoing Coronary #Angiography for Acute Myocardial Infarction: The SILVER-AMI Study
..Comorbid diseases and aging-related conditions were both more common among individuals experiencing acute kidney injury. However, after multivariable adjustment, no aging-related conditions were retained. There were 11 risk factors in the final model; the strongest were heart failure on presentation (odds ratio [OR] 1.91; 95% confidence interval [CI], 1.41-2.59), body mass index [BMI] >30 (vs BMI 18-25: OR 1.75; 95% CI, 1.27-2.42), and nonwhite race (OR 1.65; 95% CI, 1.16-2.33). The final model achieved an area under the receiver operating characteristic curve of 0.72 and was well calibrated (Hosmer-Lemeshow P = .50). Acute kidney injury was independently associated with 6-month mortality (OR 1.98; 95% CI, 1.36-2.88) but not readmission (OR 1.26; 95% CI, 0.98-1.61).
Conclusions
Acute kidney injury is common among older adults with acute myocardial infarction undergoing coronary angiography. Predictors largely mirrored those in previous studies of younger individuals, which suggests that geriatric conditions mediate their influence through other risk factors
https://bit.ly/38zXjxL
Acute #Kidney Injury Among Older Patients Undergoing Coronary #Angiography for Acute Myocardial Infarction: The SILVER-AMI Study
..Comorbid diseases and aging-related conditions were both more common among individuals experiencing acute kidney injury. However, after multivariable adjustment, no aging-related conditions were retained. There were 11 risk factors in the final model; the strongest were heart failure on presentation (odds ratio [OR] 1.91; 95% confidence interval [CI], 1.41-2.59), body mass index [BMI] >30 (vs BMI 18-25: OR 1.75; 95% CI, 1.27-2.42), and nonwhite race (OR 1.65; 95% CI, 1.16-2.33). The final model achieved an area under the receiver operating characteristic curve of 0.72 and was well calibrated (Hosmer-Lemeshow P = .50). Acute kidney injury was independently associated with 6-month mortality (OR 1.98; 95% CI, 1.36-2.88) but not readmission (OR 1.26; 95% CI, 0.98-1.61).
Conclusions
Acute kidney injury is common among older adults with acute myocardial infarction undergoing coronary angiography. Predictors largely mirrored those in previous studies of younger individuals, which suggests that geriatric conditions mediate their influence through other risk factors
https://bit.ly/38zXjxL
Acute #kidney injury after primary total hip #arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization
https://2medical.news/2020/03/17/acute-kidney-injury-after-primary-total-hip-arthroplasty-a-risk-multiplier-for-complication-mortality-and-healthcare-utilization/
To assess whether acute kidney injury (AKI) is associated with more complications and higher healthcare utilization in people undergoing primary total hip arthroplasty (THA).. ..Adjusted for age, gender, race, income, underlying diagnosis, medical comorbidity, and the insurance payer, AKI in people who underwent primary THA was associated with significantly higher OR (95% CI) of (1) implant infection, 2.34 (95% CI, 1.87, 2.93); (2) transfusion, 2.46 …
https://2medical.news/2020/03/17/acute-kidney-injury-after-primary-total-hip-arthroplasty-a-risk-multiplier-for-complication-mortality-and-healthcare-utilization/
To assess whether acute kidney injury (AKI) is associated with more complications and higher healthcare utilization in people undergoing primary total hip arthroplasty (THA).. ..Adjusted for age, gender, race, income, underlying diagnosis, medical comorbidity, and the insurance payer, AKI in people who underwent primary THA was associated with significantly higher OR (95% CI) of (1) implant infection, 2.34 (95% CI, 1.87, 2.93); (2) transfusion, 2.46 …
EMA advises continued use of medicines for #hypertension, heart or #kidney disease during COVID-19 pandemic
https://2medical.news/2020/04/02/ema-advises-continued-use-of-medicines-for-hypertension-heart-or-kidney-disease-during-covid-19-pandemic/
EMA is aware of recent media reports and publications which question whether some medicines, for instance angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs, or sartan medicines), could worsen coronavirus disease (COVID-19). ACE inhibitors and ARBs are most commonly used for treating patients with high blood pressure, heart failure or kidney disease. It is important that patients do not interrupt their treatment with …
https://2medical.news/2020/04/02/ema-advises-continued-use-of-medicines-for-hypertension-heart-or-kidney-disease-during-covid-19-pandemic/
EMA is aware of recent media reports and publications which question whether some medicines, for instance angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs, or sartan medicines), could worsen coronavirus disease (COVID-19). ACE inhibitors and ARBs are most commonly used for treating patients with high blood pressure, heart failure or kidney disease. It is important that patients do not interrupt their treatment with …
ACUTE #KIDNEY INJURY IN PATIENTS HOSPITALIZED WITH #COVID-19
https://2medical.news/2020/05/21/acute-kidney-injury-in-patients-hospitalized-with-covid-19/
The rate of acute kidney injury (AKI) associated with patients hospitalized with Covid-19, and associated outcomes are not well understood. This study describes the presentation, risk factors and outcomes of AKI in patients hospitalized with Covid-19. We reviewed the health records for all patients hospitalized with Covid-19 between March 1, and April 5, 2020, at 13 academic and community hospitals in metropolitan New York. Patients …
https://2medical.news/2020/05/21/acute-kidney-injury-in-patients-hospitalized-with-covid-19/
The rate of acute kidney injury (AKI) associated with patients hospitalized with Covid-19, and associated outcomes are not well understood. This study describes the presentation, risk factors and outcomes of AKI in patients hospitalized with Covid-19. We reviewed the health records for all patients hospitalized with Covid-19 between March 1, and April 5, 2020, at 13 academic and community hospitals in metropolitan New York. Patients …
The change in #kidney function was associated with #carotid artery plaque in a community-based population: a cohort study
https://2medical.news/2020/09/01/the-change-in-kidney-function-was-associated-with-carotid-artery-plaque-in-a-community-based-population-a-cohort-study/
We performed the current study to evaluate the association between dynamic change in estimated glomerular filtration rate (eGFR) and the risk of carotid artery plaque (CAP) in a community-based population A total number of 37,093 Chinese adults (21,790 men and 15,303 women, aged 42.6±11.6 years) free of chronic kidney diseases were enrolled. The change in eGFR was calculated based on two measurements in 2013 and …
https://2medical.news/2020/09/01/the-change-in-kidney-function-was-associated-with-carotid-artery-plaque-in-a-community-based-population-a-cohort-study/
We performed the current study to evaluate the association between dynamic change in estimated glomerular filtration rate (eGFR) and the risk of carotid artery plaque (CAP) in a community-based population A total number of 37,093 Chinese adults (21,790 men and 15,303 women, aged 42.6±11.6 years) free of chronic kidney diseases were enrolled. The change in eGFR was calculated based on two measurements in 2013 and …
Natural history of acute #kidney disease in patients with #cirrhosis
https://2medical.news/2020/09/17/natural-history-of-acute-kidney-disease-in-patients-with-cirrhosis/
In 2012, KDIGO group proposed new definitions for Acute Kidney Injury (AKI), Acute Kidney Disease (AKD) and Chronic Kidney Disease (CKD). According to the definition adapted by the International Club of Ascites (ICA), AKI has been extensively investigated in patients with cirrhosis. On the contrary, there are currently no data on the epidemiology and clinical outcome of AKD in these patients. The aim of the …
https://2medical.news/2020/09/17/natural-history-of-acute-kidney-disease-in-patients-with-cirrhosis/
In 2012, KDIGO group proposed new definitions for Acute Kidney Injury (AKI), Acute Kidney Disease (AKD) and Chronic Kidney Disease (CKD). According to the definition adapted by the International Club of Ascites (ICA), AKI has been extensively investigated in patients with cirrhosis. On the contrary, there are currently no data on the epidemiology and clinical outcome of AKD in these patients. The aim of the …
#Dapagliflozin in Patients with Chronic #Kidney Disease
https://2medical.news/2020/09/28/dapagliflozin-in-patients-with-chronic-kidney-disease/
Patients with chronic kidney disease have a high risk of adverse kidney and cardiovascular outcomes. The effect of dapagliflozin in patients with chronic kidney disease, with or without type 2 diabetes, is not known.. ..The independent data monitoring committee recommended stopping the trial because of efficacy. Over a median of 2.4 years, a primary outcome event occurred in 197 of 2152 participants (9.2%) in the …
https://2medical.news/2020/09/28/dapagliflozin-in-patients-with-chronic-kidney-disease/
Patients with chronic kidney disease have a high risk of adverse kidney and cardiovascular outcomes. The effect of dapagliflozin in patients with chronic kidney disease, with or without type 2 diabetes, is not known.. ..The independent data monitoring committee recommended stopping the trial because of efficacy. Over a median of 2.4 years, a primary outcome event occurred in 197 of 2152 participants (9.2%) in the …
#Hypoalbuminemia is associated with increased risk of acute #kidney injury in hospitalized patients: A meta-analysis
https://2medical.news/2020/10/24/hypoalbuminemia-is-associated-with-increased-risk-of-acute-kidney-injury-in-hospitalized-patients-a-meta-analysis/
Highlights • Each 1.0 g/dL of serum albumin decrement was associated with increased odds of AKI (OR 1.685; 95% CI, 1.302–2.179). • The risk factors for AKI in hypoalbuminemic patients include 1) age ≥ 70 years and 2) baseline serum albumin level > 3.2 g/dL. • The association between hypoalbuminemia and overall mortality from AKI remained inconclusive as there was potential publication bias. https://bit.ly/2HeU31v
https://2medical.news/2020/10/24/hypoalbuminemia-is-associated-with-increased-risk-of-acute-kidney-injury-in-hospitalized-patients-a-meta-analysis/
Highlights • Each 1.0 g/dL of serum albumin decrement was associated with increased odds of AKI (OR 1.685; 95% CI, 1.302–2.179). • The risk factors for AKI in hypoalbuminemic patients include 1) age ≥ 70 years and 2) baseline serum albumin level > 3.2 g/dL. • The association between hypoalbuminemia and overall mortality from AKI remained inconclusive as there was potential publication bias. https://bit.ly/2HeU31v
Low High‐Sensitivity C‐ #Reactive Protein Level in Korean Patients With Chronic #Kidney Disease and Its Predictive Significance for Cardiovascular Events, Mortality, and Adverse Kidney Outcomes: Results From KNOW‐CKD
https://2medical.news/2020/11/01/low-high%E2%80%90sensitivity-c%E2%80%90-reactive-protein-level-in-korean-patients-with-chronic-kidney-disease-and-its-predictive-significance-for-cardiovascular-events-mortality-and-adverse-kidney/
Inflammation levels are lower in East Asians than in Western people. We studied the association between high‐sensitivity hs‐CRP (C‐reactive protein) and adverse outcomes in Korean patients with chronic kidney disease. Methods and Results We included 2018 participants from the KNOW‐CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) between April 2011 and February 2016. The primary outcome was a composite of extended …
https://2medical.news/2020/11/01/low-high%E2%80%90sensitivity-c%E2%80%90-reactive-protein-level-in-korean-patients-with-chronic-kidney-disease-and-its-predictive-significance-for-cardiovascular-events-mortality-and-adverse-kidney/
Inflammation levels are lower in East Asians than in Western people. We studied the association between high‐sensitivity hs‐CRP (C‐reactive protein) and adverse outcomes in Korean patients with chronic kidney disease. Methods and Results We included 2018 participants from the KNOW‐CKD (Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease) between April 2011 and February 2016. The primary outcome was a composite of extended …
The #Kidney Disease: Improving Global Outcomes (KDIGO) 2020 Clinical Practice Guideline for #Diabetes Management in Chronic Kidney Disease (CKD)
https://2medical.news/2020/11/14/the-kidney-disease-improving-global-outcomes-kdigo-2020-clinical-practice-guideline-for-diabetes-management-in-chronic-kidney-disease-ckd/
Here attached you may find the takeaways of the guidelines for patients and for clinicians. takeaways for patients: https://kdigo.org/wp-content/uploads/2018/03/Top-10-Takeaways-Patients.pdf takeaways for clinicians: https://kdigo.org/wp-content/uploads/2018/03/Top-10-Takeaways-Clinicians.pdf
https://2medical.news/2020/11/14/the-kidney-disease-improving-global-outcomes-kdigo-2020-clinical-practice-guideline-for-diabetes-management-in-chronic-kidney-disease-ckd/
Here attached you may find the takeaways of the guidelines for patients and for clinicians. takeaways for patients: https://kdigo.org/wp-content/uploads/2018/03/Top-10-Takeaways-Patients.pdf takeaways for clinicians: https://kdigo.org/wp-content/uploads/2018/03/Top-10-Takeaways-Clinicians.pdf
Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
https://2medical.news/2021/06/03/association-of-depressive-symptoms-with-rapid-kidney-function-decline-in-adults-with-normal-kidney-function/
https://2medical.news/2021/06/03/association-of-depressive-symptoms-with-rapid-kidney-function-decline-in-adults-with-normal-kidney-function/
2Medical.News
Association of #Depressive Symptoms with Rapid #Kidney Function Decline in Adults with Normal Kidney Function
The relationship of depressive symptoms with kidney function remains poorly investigated. We aimed to evaluate the prospective association between depressive symptoms and rapid decline in kidney fu…
Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
https://2medical.news/2021/06/28/meta-analysis-of-the-relationship-between-abdominal-obesity-and-diabetic-kidney-disease-in-type-2-diabetic-patients/
https://2medical.news/2021/06/28/meta-analysis-of-the-relationship-between-abdominal-obesity-and-diabetic-kidney-disease-in-type-2-diabetic-patients/
2Medical.News
Meta-Analysis of the Relationship between Abdominal #Obesity and Diabetic #Kidney Disease in Type 2 #Diabetic Patients
The meta-analysis aimed to investigate the association of visceral fat area (VFA), waist circumference (WC), waist-hip ratio (WHR) and waist-height ratio (WHtR) with diabetic kidney disease (DKD) i…
Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
https://2medical.news/2021/08/15/second-line-therapy-for-type-2-diabetes-management-the-treatment-benefit-paradox-of-cardiovascular-and-kidney-comorbidities/
https://2medical.news/2021/08/15/second-line-therapy-for-type-2-diabetes-management-the-treatment-benefit-paradox-of-cardiovascular-and-kidney-comorbidities/
2Medical.News
Second-Line Therapy for Type 2 #Diabetes Management: The Treatment/Benefit Paradox of #Cardiovascular and #Kidney Comorbidities
To examine whether glucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium–glucose cotransporter 2 inhibitors (SGLT2i) are preferentially initiated among patients with cardiovascular disease…
#Metabolic Syndrome, and Not #Obesity, Is Associated with Chronic #Kidney Disease
https://2medical.news/2021/09/22/metabolic-syndrome-and-not-obesity-is-associated-with-chronic-kidney-disease/
https://2medical.news/2021/09/22/metabolic-syndrome-and-not-obesity-is-associated-with-chronic-kidney-disease/
2Medical.News
#Metabolic Syndrome, and Not #Obesity, Is Associated with Chronic #Kidney Disease
Obese (OB) patients are at increased risk of chronic kidney disease, but it is still unclear whether this can be attributed to obesity per se or to the associated metabolic derangements. The aim of…
Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease
https://2medical.news/2021/10/03/metabolic-associated-fatty-liver-disease-is-the-risk-factor-for-chronic-kidney-disease/
https://2medical.news/2021/10/03/metabolic-associated-fatty-liver-disease-is-the-risk-factor-for-chronic-kidney-disease/
2Medical.News
Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease
Background & AimsTo clarify the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD). MethodsThe participants were divided into fou…
#Choroidal and #retinal thinning in chronic #kidney disease independently associate with eGFR decline and are modifiable with treatment
https://2medical.news/2023/12/07/choroidal-and-retinal-thinning-in-chronic-kidney-disease-independently-associate-with-egfr-decline-and-are-modifiable-with-treatment/
https://2medical.news/2023/12/07/choroidal-and-retinal-thinning-in-chronic-kidney-disease-independently-associate-with-egfr-decline-and-are-modifiable-with-treatment/
2Medical.News
#Choroidal and #retinal thinning in chronic #kidney disease independently associate with eGFR decline and are modifiable with treatment
In patients with chronic kidney disease (CKD), there is an unmet need for novel biomarkers that reliably track kidney injury, demonstrate treatment-response, and predict outcomes. Here, we investig…
Self-Reported Frequency of Adding #Salt to Food and Risk of Incident Chronic #Kidney Disease
https://2medical.news/2024/01/31/self-reported-frequency-of-adding-salt-to-food-and-risk-of-incident-chronic-kidney-disease/
https://2medical.news/2024/01/31/self-reported-frequency-of-adding-salt-to-food-and-risk-of-incident-chronic-kidney-disease/
2Medical.News
Self-Reported Frequency of Adding #Salt to Food and Risk of Incident Chronic #Kidney Disease
Importance The self-reported frequency of adding salt to foods could reflect a person’s long-term salt taste preference, and salt intake has been associated with increased risk of cardiovascular d…