!!
Changes in #Kidney Function Do Not Differ between Healthy Adults Consuming #Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis
https://academic.oup.com/jn/article/148/11/1760/5153345
Higher-protein (HP) diets are advocated for several reasons, including mitigation of sarcopenia, but their effects on kidney function are unclear
Methods
We conducted a systematic review and meta-analysis of trials comparing HP (≥1.5 g/kg body weight or ≥20% energy intake or ≥100 g protein/d) with normal- or lower-protein (NLP; ≥5% less energy intake from protein/d compared with HP group) intakes on kidney function.
The post-only comparison showed a trivial effect for GFR to be higher after HP intakes standardized mean difference (SMD): 0.19; 95% CI: 0.07, 0.31; P = 0.002. The change in GFR did not differ between interventions (SMD: 0.11; 95% CI: −0.05, 0.27; P = 0.16). There was a linear relation between protein intake and GFR in the post-only comparison (r = 0.332, P = 0.03), but not between protein intake and the change in GFR (r = 0.184, P = 0.33). The main limitation of the current analysis is the unclear risk of selection bias of the included trials.
Conclusions
Postintervention GFR comparisons indicate that HP diets result in higher GFRs; however, when changes in GFR were compared, dietary protein had no effect. Our analysis indicates that HP intakes do not adversely influence kidney function on GFR in healthy adults.
Changes in #Kidney Function Do Not Differ between Healthy Adults Consuming #Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis
https://academic.oup.com/jn/article/148/11/1760/5153345
Higher-protein (HP) diets are advocated for several reasons, including mitigation of sarcopenia, but their effects on kidney function are unclear
Methods
We conducted a systematic review and meta-analysis of trials comparing HP (≥1.5 g/kg body weight or ≥20% energy intake or ≥100 g protein/d) with normal- or lower-protein (NLP; ≥5% less energy intake from protein/d compared with HP group) intakes on kidney function.
The post-only comparison showed a trivial effect for GFR to be higher after HP intakes standardized mean difference (SMD): 0.19; 95% CI: 0.07, 0.31; P = 0.002. The change in GFR did not differ between interventions (SMD: 0.11; 95% CI: −0.05, 0.27; P = 0.16). There was a linear relation between protein intake and GFR in the post-only comparison (r = 0.332, P = 0.03), but not between protein intake and the change in GFR (r = 0.184, P = 0.33). The main limitation of the current analysis is the unclear risk of selection bias of the included trials.
Conclusions
Postintervention GFR comparisons indicate that HP diets result in higher GFRs; however, when changes in GFR were compared, dietary protein had no effect. Our analysis indicates that HP intakes do not adversely influence kidney function on GFR in healthy adults.