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Aldo Lorenzetti M.D, Internal Medicine & Hepatology, Milano - SIMEDET Delegate
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Food & mood: a review of supplementary #prebiotic and #probiotic interventions in the treatment of #anxiety and #depression in adult
https://2medical.news/2020/07/16/food-mood-a-review-of-supplementary-prebiotic-and-probiotic-interventions-in-the-treatment-of-anxiety-and-depression-in-adult/

A bidirectional relationship exists between the brain and the gastrointestinal tract. Foods containing bacteria that positively influence the gastrointestinal microbiome are termed, probiotics; compounds that promote the flourishing of these bacteria are termed, prebiotics. Whether microbiome influencing therapies could treat psychiatric conditions, including depression and anxiety, is an area of interest. Presently, no established consensus for such treatment exists.. .. 7 studies were identified. All …
#Apathy, but not #depression, predicts all-cause dementia in cerebral small vessel disease
https://2medical.news/2020/07/18/apathy-but-not-depression-predicts-all-cause-dementia-in-cerebral-small-vessel-disease/

To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using baseline apathy and depression scores in both datasets. Change in …
The temporal association between incident late‐life #depression and incident #dementia
https://2medical.news/2020/08/01/the-temporal-association-between-incident-late%E2%80%90life-depression-and-incident-dementia/

There is an established association between depression and subsequent dementia. The present study examined temporal associations between incident late‐life depression and subsequent dementia, also considering age and sex.. ..Incident depression was associated with a higher risk of subsequent dementia (incidence rate ratios (IRR) adjusted for age and sex: IRR = 1.58, 95% CI = 1.51‐1.64). The strongest association was found for the shortest interval of …
#Depression and subsequent risk for incident rheumatoid #arthritis among women
https://2medical.news/2020/09/21/depression-and-subsequent-risk-for-incident-rheumatoid-arthritis-among-women/

We investigated the association of depression with subsequent risk of rheumatoid arthritis (RA) by serologic phenotype.. ..Among 195,358 women, we identified 858 incident RA cases (65% seropositive) over 3,087,556 person‐years (median 17.9 years/participant). Compared to women without depression, those with depression had multivariable HRs (95%CIs) of: 1.28(1.10‐1.48) for all RA; 1.12(0.93‐1.35) for seropositive RA; and 1.63(1.27‐2.09) for seronegative RA. When analyzing components of the composite …
Associations Between Social #Anxiety, #Depression, and Use of #Mobile Dating Applications
https://2medical.news/2020/11/14/associations-between-social-anxiety-depression-and-use-of-mobile-dating-applications/

This study explores associations between symptoms of social anxiety (SA) and depression with participants’ extent of dating app use, self-reported motivations for dating app use, and likelihood of initiating interaction with dating app matches. Three-hundred seventy-four participants completed an online battery of surveys that examined psychopathology and dating app use. SA and depression symptoms were positively associated with participants’ extent of dating app use, and …
#Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
https://2medical.news/2021/01/11/depression-and-increased-risk-of-alzheimers-dementia-longitudinal-analyses-of-modifiable-risk-and-sex-related-factors/

Highlights •We investigated whether recent and/or remote depression was associated with increased risk of Alzheimer’s Dementia (AD) and whether this risk differed between men and women. •Recent depression was independently associated with increased risk of incident AD while remote depression was not. Recent depression was predictive of AD development in females, but not in males, while sex did not moderate recent depression-associated risk of developing …
State-dependent responses to intracranial brain stimulation in a patient with #depression
https://2medical.news/2021/01/25/state-dependent-responses-to-intracranial-brain-stimulation-in-a-patient-with-depression/

Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent. Results provide proof …
Risk of #Cardiovascular Disease Mortality in Relation to #Depression and 14 Common Risk Factors
https://2medical.news/2021/02/15/risk-of-cardiovascular-disease-mortality-in-relation-to-depression-and-14-common-risk-factors/

Depression has been linked to a worse prognosis of Cardiovascular disease (CVD), and these two diseases share a variety of common risk factors such as unhealthy lifestyles and chronic medical conditions. However, the potential role of these common risk factors in modulating the association between depression and CVD mortality and whether the co-occurrence of depression and a specific common risk factor has a cumulative impact …
Common and specific aspects of #anxiety and #depression and the #metabolic syndrome
https://2medical.news/2021/03/06/common-and-specific-aspects-of-anxiety-and-depression-and-the-metabolic-syndrome/

The associations of anxiety and depression with metabolic syndrome (MetS) are not consistent across studies. Anxiety and depression are highly correlated and traditional methods don’t take the structure of this correlation into account. Our aim is to disentangle the relationship of these emotional conditions with MetS, using bifactor models, modelling both general and specific aspects between anxiety and depression. Methods Bifactor models were tested using …
Do -Blockers Cause #Depression? Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy
https://2medical.news/2021/03/18/do-%CE%B2-blockers-cause-depression-systematic-review-and-meta-analysis-of-psychiatric-adverse-events-during-%CE%B2-blocker-therapy/

β-Blockers are important drugs in the treatment of cardiovascular diseases. They are suspected of inducing various psychiatric adverse events (PAEs), particularly depression, affecting cardiovascular morbidity and mortality. We performed a systematic search for double-blind, randomized controlled trials investigating β-blockers to analyze the risk of PAEs or withdrawal of therapy due to PAEs. We extracted the frequencies of PAEs and rates of withdrawals and reviewed them …