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Inhibition of #Mevalonate Pathway Prevents Adipocyte #Browning in Mice and Men by Affecting Protein Prenylation

https://www.sciencedirect.com/science/article/pii/S1550413118307368?via%3Dihub

Highlights

• The mevalonate pathway is important for adipose tissue browning in mouse and human

• Statin use is inversely correlated with brown fat activity in humans

• Geranylgeranylation of small GTP-binding proteins promotes adipocyte browning

• Small GTP-binding proteins regulate F-actin formation and YAP1/TAZ stability

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#Caffeine exposure induces #browning features in adipose tissue in vitro and in vivo

https://www.nature.com/articles/s41598-019-45540-1

Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1).

Diet can modulate UCP1 function but the capacity of individual nutrients to promote the abundance and activity of UCP1 is not well established. Caffeine consumption has been associated with loss of body weight and increased energy expenditure, but whether it can activate UCP1 is unknown

In vivo, drinking coffee (but not water) stimulated the temperature of the supraclavicular region, which co-locates to the main region of BAT in adult humans, and is indicative of thermogenesis.

Taken together, these results demonstrate that caffeine can promote BAT function at thermoneutrality and may have the potential to be used therapeutically in adult humans