Relationships Between #Caffeine Intake and Risk for Probable #Dementia or Global Cognitive Impairment: The Women’s Health Initiative Memory Study
http://m.biomedgerontology.oxfordjournals.org/content/early/2016/09/20/gerona.glw078.full
Conclusion: Our findings suggest lower odds of probable dementia or cognitive impairment in older women whose caffeine consumption was above median for this group and are consistent with the existing literature showing an inverse association between caffeine intake and age-related cognitive impairment.
http://m.biomedgerontology.oxfordjournals.org/content/early/2016/09/20/gerona.glw078.full
Conclusion: Our findings suggest lower odds of probable dementia or cognitive impairment in older women whose caffeine consumption was above median for this group and are consistent with the existing literature showing an inverse association between caffeine intake and age-related cognitive impairment.
Short-term Effects of High-Dose #Caffeine on Cardiac #Arrhythmias in Patients With Heart Failure
A Randomized Clinical Trial
http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2569283
Conclusions and Relevance Acute ingestion of high doses of caffeine did not induce arrhythmias in patients with systolic heart failure and at high risk for ventricular arrhythmias.
A Randomized Clinical Trial
http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2569283
Conclusions and Relevance Acute ingestion of high doses of caffeine did not induce arrhythmias in patients with systolic heart failure and at high risk for ventricular arrhythmias.
Jamanetwork
Caffeine and Cardiac Arrhythmias in Patients With Heart Failure
This randomized clinical trial evaluates the short-term effects of high-dose caffeine consumption vs placebo in patients with heart failure at increased risk for arrhythmic events.
#Stair walking is more energizing than low dose #caffeine in sleep deprived young women
http://www.sciencedirect.com/science/article/pii/S0031938416310666
The apriori primary aim of this experiment was to compare the influence of 10-min of low-to-moderate intensity stair walking to the consumption of capsules containing 50 mg caffeine or flour (placebo) on feelings of energy in physically active, college female caffeine users with chronic insufficient sleep. Effects on secondary outcomes related to feelings of energy also were assessed.
Conclusion
A brief bout of low-to-moderate intensity stair walking has transient energizing effects that exceed a low dose of caffeine for active young women with chronic insufficient sleep
http://www.sciencedirect.com/science/article/pii/S0031938416310666
The apriori primary aim of this experiment was to compare the influence of 10-min of low-to-moderate intensity stair walking to the consumption of capsules containing 50 mg caffeine or flour (placebo) on feelings of energy in physically active, college female caffeine users with chronic insufficient sleep. Effects on secondary outcomes related to feelings of energy also were assessed.
Conclusion
A brief bout of low-to-moderate intensity stair walking has transient energizing effects that exceed a low dose of caffeine for active young women with chronic insufficient sleep
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CDKN1B/p27 is localized in #mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for #caffeine
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004408
...In addition, mitochondrial p27 protects cardiomyocytes against apoptosis. Moreover, mitochondrial p27 is necessary and sufficient for cardiac myofibroblast differentiation. In addition, p27 deficiency and aging decrease respiration in heart mitochondria. Caffeine does not increase respiration in p27-deficient animals, whereas aged mice display improvement after 10 days of caffeine in drinking water. Moreover, caffeine induces transcriptome changes in a p27-dependent manner, affecting mostly genes relevant for mitochondrial processes. Caffeine also reduces infarct size after myocardial infarction in prediabetic mice and increases mitochondrial p27. Our data characterize mitochondrial p27 as a common denominator that improves mitochondria-dependent processes and define an increase in mitochondrial p27 as a new mode of action of caffeine
CDKN1B/p27 is localized in #mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for #caffeine
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004408
...In addition, mitochondrial p27 protects cardiomyocytes against apoptosis. Moreover, mitochondrial p27 is necessary and sufficient for cardiac myofibroblast differentiation. In addition, p27 deficiency and aging decrease respiration in heart mitochondria. Caffeine does not increase respiration in p27-deficient animals, whereas aged mice display improvement after 10 days of caffeine in drinking water. Moreover, caffeine induces transcriptome changes in a p27-dependent manner, affecting mostly genes relevant for mitochondrial processes. Caffeine also reduces infarct size after myocardial infarction in prediabetic mice and increases mitochondrial p27. Our data characterize mitochondrial p27 as a common denominator that improves mitochondria-dependent processes and define an increase in mitochondrial p27 as a new mode of action of caffeine
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Does #Caffeine Consumption Increase the Risk of New-Onset Atrial #Fibrillation?
https://www.karger.com/Article/Abstract/489843
No significant difference was found in AF incidence when the subjects consuming less than 2 cups of coffee per day were compared to subjects with higher consumption, 1.068 (0.937–1.216). The risk of AF was higher among subjects consuming less than 2 cups of coffee daily when compared to higher daily consumption subjects. A lower incidence of AF was found among people consuming more than 436 mg daily.
Conclusion: The incidence of AF is not increased by coffee consumption. In fact, we found a lower incidence of AF when caffeine consumption exceeded 436 mg/day. Therefore, based on available evidence there is no association between caffeine intake and AF risk.
Does #Caffeine Consumption Increase the Risk of New-Onset Atrial #Fibrillation?
https://www.karger.com/Article/Abstract/489843
No significant difference was found in AF incidence when the subjects consuming less than 2 cups of coffee per day were compared to subjects with higher consumption, 1.068 (0.937–1.216). The risk of AF was higher among subjects consuming less than 2 cups of coffee daily when compared to higher daily consumption subjects. A lower incidence of AF was found among people consuming more than 436 mg daily.
Conclusion: The incidence of AF is not increased by coffee consumption. In fact, we found a lower incidence of AF when caffeine consumption exceeded 436 mg/day. Therefore, based on available evidence there is no association between caffeine intake and AF risk.
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Maternal #caffeine intake during #pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study
http://bmjopen.bmj.com/content/8/3/e018895
Compared with pregnant women with low caffeine intake (<50 mg/day, 46%), women with average (50–199 mg/day, 44%), high (≥200–299 mg/day, 7%) and very high (≥300 mg/day, 3%) caffeine intakes had an increased risk of their child experiencing excess growth in infancy, after adjustment for confounders (OR=1.15, 95% CI 1.09 to 1.22, OR=1.30, 95% CI 1.16 to 1.45, OR=1.66, 95% CI 1.42 to 1.93, respectively). In utero exposure to any caffeine was associated with higher risk of overweight at age 3 years and 5 years, while the association persisted at 8 years, only for very high exposures. Any caffeine intake was associated with increased body mass index from infancy to childhood. Children prenatally exposed to caffeine intake >200 mg/day had consistently higher weight. Very high caffeine exposures were associated with higher weight gain velocity from infancy to age 8 years.
Conclusion Any caffeine consumption during pregnancy is associated with a higher risk of excess infant growth and of childhood overweight, mainly at preschool ages. Maternal caffeine intake may modify the overall weight growth trajectory of the child from birth to 8 years. This study adds supporting evidence for the current advice to reduce caffeine intake during pregnancy.
Maternal #caffeine intake during #pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study
http://bmjopen.bmj.com/content/8/3/e018895
Compared with pregnant women with low caffeine intake (<50 mg/day, 46%), women with average (50–199 mg/day, 44%), high (≥200–299 mg/day, 7%) and very high (≥300 mg/day, 3%) caffeine intakes had an increased risk of their child experiencing excess growth in infancy, after adjustment for confounders (OR=1.15, 95% CI 1.09 to 1.22, OR=1.30, 95% CI 1.16 to 1.45, OR=1.66, 95% CI 1.42 to 1.93, respectively). In utero exposure to any caffeine was associated with higher risk of overweight at age 3 years and 5 years, while the association persisted at 8 years, only for very high exposures. Any caffeine intake was associated with increased body mass index from infancy to childhood. Children prenatally exposed to caffeine intake >200 mg/day had consistently higher weight. Very high caffeine exposures were associated with higher weight gain velocity from infancy to age 8 years.
Conclusion Any caffeine consumption during pregnancy is associated with a higher risk of excess infant growth and of childhood overweight, mainly at preschool ages. Maternal caffeine intake may modify the overall weight growth trajectory of the child from birth to 8 years. This study adds supporting evidence for the current advice to reduce caffeine intake during pregnancy.
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Association of #Caffeine Intake and Caffeinated Coffee Consumption With Risk of Incident #Rosacea In Women
https://jamanetwork.com/journals/jamadermatology/fullarticle/2707780
... After adjustment for other risk factors, we found an inverse association between increased caffeine intake and risk of rosacea (hazard ratio for the highest quintile of caffeine intake vs the lowest, 0.76; 95% CI, 0.69-0.84; P < .001 for trend). A significant inverse association with risk of rosacea was also observed for caffeinated coffee consumption (HR, 0.77 for those who consumed ≥4 servings/d vs those who consumed <1/mo; 95% CI, 0.69-0.87; P < .001 for trend), but not for decaffeinated coffee (HR, 0.80; 95% CI, 0.56-1.14; P = .39 for trend). Further analyses found that increased caffeine intake from foods other than coffee (tea, soda, and chocolate) was not significantly associated with decreased risk of rosacea.
Conclusions and Relevance Increased caffeine intake from coffee was inversely associated with the risk of incident rosacea. Our findings do not support limiting caffeine intake as a means to prevent rosacea. Further studies are required to explain the mechanisms of action of these associations, to replicate our findings in other populations, and to explore the relationship of caffeine with different rosacea subtypes.
Association of #Caffeine Intake and Caffeinated Coffee Consumption With Risk of Incident #Rosacea In Women
https://jamanetwork.com/journals/jamadermatology/fullarticle/2707780
... After adjustment for other risk factors, we found an inverse association between increased caffeine intake and risk of rosacea (hazard ratio for the highest quintile of caffeine intake vs the lowest, 0.76; 95% CI, 0.69-0.84; P < .001 for trend). A significant inverse association with risk of rosacea was also observed for caffeinated coffee consumption (HR, 0.77 for those who consumed ≥4 servings/d vs those who consumed <1/mo; 95% CI, 0.69-0.87; P < .001 for trend), but not for decaffeinated coffee (HR, 0.80; 95% CI, 0.56-1.14; P = .39 for trend). Further analyses found that increased caffeine intake from foods other than coffee (tea, soda, and chocolate) was not significantly associated with decreased risk of rosacea.
Conclusions and Relevance Increased caffeine intake from coffee was inversely associated with the risk of incident rosacea. Our findings do not support limiting caffeine intake as a means to prevent rosacea. Further studies are required to explain the mechanisms of action of these associations, to replicate our findings in other populations, and to explore the relationship of caffeine with different rosacea subtypes.
Jamanetwork
Association of Caffeine and Caffeinated Coffee Intake With Risk of Incident Rosacea in Women
This large cohort study of participants in the Nurses’ Health Study II evaluates the association between risk of incident rosacea in women and caffeine intake, including caffeinated coffee consumption.
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#Caffeine exposure induces #browning features in adipose tissue in vitro and in vivo
https://www.nature.com/articles/s41598-019-45540-1
Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1).
Diet can modulate UCP1 function but the capacity of individual nutrients to promote the abundance and activity of UCP1 is not well established. Caffeine consumption has been associated with loss of body weight and increased energy expenditure, but whether it can activate UCP1 is unknown
In vivo, drinking coffee (but not water) stimulated the temperature of the supraclavicular region, which co-locates to the main region of BAT in adult humans, and is indicative of thermogenesis.
Taken together, these results demonstrate that caffeine can promote BAT function at thermoneutrality and may have the potential to be used therapeutically in adult humans
#Caffeine exposure induces #browning features in adipose tissue in vitro and in vivo
https://www.nature.com/articles/s41598-019-45540-1
Brown adipose tissue (BAT) is able to rapidly generate heat and metabolise macronutrients, such as glucose and lipids, through activation of mitochondrial uncoupling protein 1 (UCP1).
Diet can modulate UCP1 function but the capacity of individual nutrients to promote the abundance and activity of UCP1 is not well established. Caffeine consumption has been associated with loss of body weight and increased energy expenditure, but whether it can activate UCP1 is unknown
In vivo, drinking coffee (but not water) stimulated the temperature of the supraclavicular region, which co-locates to the main region of BAT in adult humans, and is indicative of thermogenesis.
Taken together, these results demonstrate that caffeine can promote BAT function at thermoneutrality and may have the potential to be used therapeutically in adult humans
Nature
Caffeine exposure induces browning features in adipose tissue in vitro and in vivo
Scientific Reports - Caffeine exposure induces browning features in adipose tissue in vitro and in vivo
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#Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-#sucrose-diet-driven lipogenesis and body #fat accumulation
The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity..
..MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from MC, MT, or DM. MC attenuated weight gain (16%) and body fat accumulation (22%). MC reduced Fasn expression in both adipose tissue (66%) and liver (37%). MC diminished pyruvate kinase (PK, 59%) and microsomal triglyceride transfer protein (MTP, 50%) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid.
Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression.
https://bit.ly/36ly80d
#Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-#sucrose-diet-driven lipogenesis and body #fat accumulation
The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity..
..MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from MC, MT, or DM. MC attenuated weight gain (16%) and body fat accumulation (22%). MC reduced Fasn expression in both adipose tissue (66%) and liver (37%). MC diminished pyruvate kinase (PK, 59%) and microsomal triglyceride transfer protein (MTP, 50%) hepatic expression. In silico, neochlorogenic acid interacted with PK and MTP allosteric sites. FAS β‐ketoacyl reductase domain showed the highest affinity to 3,5-dicaffeoylquinic acid.
Caffeine suppressed lipid accumulation and body weight gain, through the modulation of lipogenic gene expression.
https://bit.ly/36ly80d
Sciencedirect
Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-sucrose-diet-driven…
The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid acc…
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Effects of #Caffeine and Acute Aerobic #Exercise on Working Memory and Caffeine Withdrawal
Studies show that a single bout of exercise confers cognitive benefits. However, many individuals use psychoactive substances such as caffeine to enhance cognitive performance..
The objectives of this study were to compare the effects of acute moderate intensity aerobic exercise to caffeine on working memory (WM) and caffeine withdrawal symptoms (CWS). In Phase I, non-caffeine (n = 29) and caffeine consumers (n = 30) completed a WM assessment, followed by acute exercise and caffeine.
In Phase II, caffeine consumers (n = 25) from Phase I underwent the WM assessment and reported CWS following a 12-hour deprivation period. Acute moderate intensity aerobic exercise and caffeine (1.2 mg/kg) significantly improved WM accuracy and reduced CWS comparably. WM performance was not reduced following caffeine deprivation..
https://go.nature.com/37KcXpg
Effects of #Caffeine and Acute Aerobic #Exercise on Working Memory and Caffeine Withdrawal
Studies show that a single bout of exercise confers cognitive benefits. However, many individuals use psychoactive substances such as caffeine to enhance cognitive performance..
The objectives of this study were to compare the effects of acute moderate intensity aerobic exercise to caffeine on working memory (WM) and caffeine withdrawal symptoms (CWS). In Phase I, non-caffeine (n = 29) and caffeine consumers (n = 30) completed a WM assessment, followed by acute exercise and caffeine.
In Phase II, caffeine consumers (n = 25) from Phase I underwent the WM assessment and reported CWS following a 12-hour deprivation period. Acute moderate intensity aerobic exercise and caffeine (1.2 mg/kg) significantly improved WM accuracy and reduced CWS comparably. WM performance was not reduced following caffeine deprivation..
https://go.nature.com/37KcXpg
Scientific Reports
Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal
Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal
Association Between Maternal #Caffeine Consumption and Metabolism and Neonatal Anthropometry
https://2medical.news/2021/03/29/association-between-maternal-caffeine-consumption-and-metabolism-and-neonatal-anthropometry/
Higher caffeine consumption during pregnancy has been associated with lower birth weight. However, associations of caffeine consumption, based on both plasma concentrations of caffeine and its metabolites, and self-reported caffeinated beverage intake, with multiple measures of neonatal anthropometry, have yet to be examined. Objective To evaluate the association between maternal caffeine intake and neonatal anthropometry, testing effect modification by fast or slow caffeine metabolism genotype. …
https://2medical.news/2021/03/29/association-between-maternal-caffeine-consumption-and-metabolism-and-neonatal-anthropometry/
Higher caffeine consumption during pregnancy has been associated with lower birth weight. However, associations of caffeine consumption, based on both plasma concentrations of caffeine and its metabolites, and self-reported caffeinated beverage intake, with multiple measures of neonatal anthropometry, have yet to be examined. Objective To evaluate the association between maternal caffeine intake and neonatal anthropometry, testing effect modification by fast or slow caffeine metabolism genotype. …
#Caffeine increases maximal #fat oxidation during a graded exercise test: is there a diurnal variation?
https://2medical.news/2021/03/30/caffeine-increases-maximal-fat-oxidation-during-a-graded-exercise-test-is-there-a-diurnal-variation/
There is evidence that caffeine increases the maximal fat oxidation rate (MFO) and aerobic capacity, which are known to be lower in the morning than in the afternoon. This paper examines the effect of caffeine intake on the diurnal variation of MFO during a graded exercise test in active men. Methods Using a triple-blind, placebo-controlled, crossover experimental design, 15 active caffeine-naïve men (age: 32 ± 7 years) completed …
https://2medical.news/2021/03/30/caffeine-increases-maximal-fat-oxidation-during-a-graded-exercise-test-is-there-a-diurnal-variation/
There is evidence that caffeine increases the maximal fat oxidation rate (MFO) and aerobic capacity, which are known to be lower in the morning than in the afternoon. This paper examines the effect of caffeine intake on the diurnal variation of MFO during a graded exercise test in active men. Methods Using a triple-blind, placebo-controlled, crossover experimental design, 15 active caffeine-naïve men (age: 32 ± 7 years) completed …
The impact of #caffeine consumption on clinical symptoms in patients with #bipolar disorder: A systematic review
https://2medical.news/2021/06/04/the-impact-of-caffeine-consumption-on-clinical-symptoms-in-patients-with-bipolar-disorder-a-systematic-review/
https://2medical.news/2021/06/04/the-impact-of-caffeine-consumption-on-clinical-symptoms-in-patients-with-bipolar-disorder-a-systematic-review/
2Medical.News
The impact of #caffeine consumption on clinical symptoms in patients with #bipolar disorder: A systematic review
In healthy populations, caffeine appears to have beneficial effects on health; however, patients with bipolar disorder (BD) are routinely advised to limit caffeine use in psychoeducation programmes…
Effects of chronic #caffeine on patterns of #brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice
https://2medical.news/2023/10/02/effects-of-chronic-caffeine-on-patterns-of-brain-blood-flow-and-behavior-throughout-the-sleep-wake-cycle-in-freely-behaving-mice/
https://2medical.news/2023/10/02/effects-of-chronic-caffeine-on-patterns-of-brain-blood-flow-and-behavior-throughout-the-sleep-wake-cycle-in-freely-behaving-mice/
2Medical.News
Effects of chronic #caffeine on patterns of #brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice
Caffeine has significant effects on neurovascular activity and behavior throughout the sleep–wake cycle. We used a minimally invasive microchip/video system to continuously record effects of caffei…
Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
https://2medical.news/2024/03/08/genetic-investigation-into-the-broad-health-implications-of-caffeine-evidence-from-phenome-wide-proteome-wide-and-metabolome-wide-mendelian-randomization/
https://2medical.news/2024/03/08/genetic-investigation-into-the-broad-health-implications-of-caffeine-evidence-from-phenome-wide-proteome-wide-and-metabolome-wide-mendelian-randomization/
2Medical.News
Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome…
BackgroundCaffeine is one of the most utilized drugs in the world, yet its clinical effects are not fully understood. Circulating caffeine levels are influenced by the interplay between consumption…