#Mediterranean Diet With No Restriction on #Fat Intake

http://annals.org/mobile/article.aspx?articleid=2534409

Conclusion: Limited evidence suggests that a Mediterranean diet with no restriction on fat intake may reduce the incidence of cardiovascular events, breast cancer, and type 2 diabetes mellitus but may not affect all-cause mortality.

Prospective association of the #Mediterranean diet with #cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk study

https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0677-4

Conclusions
Greater adherence to the Mediterranean diet was associated with lower CVD incidence and mortality in the UK. This diet has an important population health impact for the prevention of CVD.

#Mediterranean Diet Improves High-Density #Lipoprotein Function in High-Cardiovascular-Risk Individuals

http://circ.ahajournals.org/content/135/7/633

Adherence to a TMD induced these beneficial changes by improving HDL oxidative status and composition. The 3 diets increased the percentage of large HDL particles (relative to baseline, P<0.001).

Conclusions: The TMD, especially when enriched with virgin olive oil, improved HDL atheroprotective functions in humans.

#Mediterranean diet adherence and risk of postmenopausal #breast cancer: results of a cohort study and meta-analysis

http://onlinelibrary.wiley.com/doi/10.1002/ijc.30654/full

In meta-analyses, summary HRs for high versus low MD adherence were 0.94 for total postmenopausal breast cancer, 0.98 for ER+, 0.73 for ER− and 0.77 for ER − PR− breast cancer. Our findings support an inverse association between MD adherence and, particularly, receptor negative breast cancer. This may have important implications for prevention because of the poorer prognosis of these breast cancer subtypes.

A Comparison of Alkaline Water and #Mediterranean Diet vs Proton #Pump Inhibition for Treatment of Laryngopharyngeal #Reflux
http://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2652893

Laryngopharyngeal reflux (LPR) is a common disorder with protean manifestations in the head and neck. In this retrospective study, we report the efficacy of a wholly dietary approach using alkaline water, a plant-based, Mediterranean-style diet, and standard reflux precautions compared with that of the traditional treatment approach of proton pump inhibition (PPI) and standard reflux precautions

Conclusions and Relevance Our data suggest that the effect of PPI on the RSI Reflux Symptom Index based on proportion reaching a 6-point reduction in RSI is not significantly better than that of alkaline water, a plant-based, Mediterranean-style diet, and standard reflux precautions, although the difference in the 2 treatments could be clinically meaningful in favor of the dietary approach. The percent reduction in RSI was significantly greater with the dietary approach. Because the relationship between percent change and response to treatment has not been studied, the clinical significance of this difference requires further study. Nevertheless, this study suggests that a plant-based diet and alkaline water should be considered in the treatment of LPR. This approach may effectively improve symptoms and could avoid the costs and adverse effects of pharmacological intervention as well as afford the additional health benefits associated with a healthy, plant-based diet

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Association Between #Mediterranean Anti-inflammatory Dietary Profile and Severity of #Psoriasis

https://jamanetwork.com/journals/jamadermatology/fullarticle/2687981#193430799

Of the 158 361 total NutriNet-Santé participants, 35 735 (23%) replied to the psoriasis questionnaire. The mean (SD) age of the respondents was 47.5 (14.0) years; 27 220 (76%) of the respondents were women. Of these 35 735 respondents, 3557 (10%) individuals reported having psoriasis. The condition was severe in 878 cases (24.7%), and 299 (8.4%) incident cases were recorded (those arising more than 2 years after participant inclusion in the cohort). After adjustment for confounding factors, a significant inverse relationship was found between the MEDI-LITE score and having severe psoriasis: odds ratio (OR), 0.71; 95% CI, 0.55-0.92 for the MEDI-LITE score’s second tertile (score of 8 to 9); and OR, 0.78; 95% CI, 0.59-1.01 for the third tertile (score of 10 to 18).

Conclusions and Relevance Patients with severe psoriasis displayed low levels of adherence to the Mediterranean diet; this finding supports the hypothesis that the Mediterranean diet may slow the progression of psoriasis. If these findings are confirmed, adherence to a Mediterranean diet should be integrated into the routine management of moderate to severe psoriasis

#Mediterranean diet intervention alters the gut microbiome in older people reducing #frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

..Adherence to the diet was associated with specific microbiome alterations. Taxa enriched by adherence to the diet were positively associated with several markers of lower frailty and improved cognitive function, and negatively associated with inflammatory markers including C-reactive protein and interleukin-17.

Analysis of the inferred microbial metabolite profiles indicated that the diet-modulated microbiome change was associated with an increase in short/branch chained fatty acid production and lower production of secondary bile acids, p-cresols, ethanol and carbon dioxide. Microbiome ecosystem network analysis showed that the bacterial taxa that responded positively to the MedDiet intervention occupy keystone interaction positions, whereas frailty-associated taxa are peripheral in the networks.

Conclusion Collectively, our findings support the feasibility of improving the habitual diet to modulate the gut microbiota which in turn has the potential to promote healthier ageing.

https://bit.ly/3bLC8ug

Adherence to a #Mediterranean diet and #cognitive function in the Age‐Related Eye Disease Studies 1 & 2
https://2medical.news/2020/04/29/adherence-to-a-mediterranean-diet-and-cognitive-function-in-the-age%E2%80%90related-eye-disease-studies-1-2/

The objective was to determine whether closer adherence to the alternative Mediterranean Diet (aMED) was associated with altered cognitive function.. ..Odds ratios for cognitive impairment, in aMED tertile 3 (vs 1), were 0.36 (P = .0001) for Modified Mini‐Mental State (<80) and 0.56 (P = .001) for composite score in AREDS, and 0.56 for Telephone Interview Cognitive Status‐Modified (<30) and 0.48 for composite score (each …

#Mediterranean diet, #stress resilience, and aging in nonhuman primates
https://2medical.news/2020/11/24/mediterranean-diet-stress-resilience-and-aging-in-nonhuman-primates/

Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the effects of stress. However, long-term studies of diet effects on stress reactive systems are not …

#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age

https://2medical.news/2021/05/10/mediterranean-diet-alzheimer-disease-biomarkers-and-brain-atrophy-in-old-age/

Adherence to #Mediterranean diet is inversely associated with #depressive symptoms in older women: findings from the NutBrain Study

https://2medical.news/2024/03/01/adherence-to-mediterranean-diet-is-inversely-associated-with-depressive-symptoms-in-older-women-findings-from-the-nutbrain-study/

#Mediterranean #Diet Adherence and Risk of All-Cause #Mortality in #Women

https://2medical.news/2024/06/03/mediterranean-diet-adherence-and-risk-of-all-cause-mortality-in-women/