Fighting Alzheimer’s.
Researchers from the University of Barcelona are working to develop new compounds that can bind to specific receptors in the brain linked to Alzheimer’s disease. Their studies in mice improved the cognitive deficit and the biomarkers related to the disease.
Their work has been published in the European Journal of Medicinal Chemistry: https://www.sciencedirect.com/science/article/abs/pii/S0223523421003895?via%3Dihub
#sciencenews #biology #neuroscience
Researchers from the University of Barcelona are working to develop new compounds that can bind to specific receptors in the brain linked to Alzheimer’s disease. Their studies in mice improved the cognitive deficit and the biomarkers related to the disease.
Their work has been published in the European Journal of Medicinal Chemistry: https://www.sciencedirect.com/science/article/abs/pii/S0223523421003895?via%3Dihub
#sciencenews #biology #neuroscience
Sciencedirect
Benzofuranyl-2-imidazoles as imidazoline I2 receptor ligands for Alzheimer's disease
Recent findings unveil the pharmacological modulation of imidazoline I2 receptors (I2-IR) as a novel strategy to face unmet medical neurodegenerative …
Vision in mice.
Mouse vision was thought to be different to that of humans because humans have a region of the retina specialized for fine details called the 'fovea' whereas mice do not. However, researchers from the Netherlands Institute of Neuroscience have shown that the visual cortex of mice in fact contains a region of enhanced visual sensitivity - the 'focea'. This makes mice a better model for human vision than previously predicted.
The results can be read in Nature Communications: http://dx.doi.org/10.1038/s41467-021-24311-5
#sciencenews #biology #neuroscience
Mouse vision was thought to be different to that of humans because humans have a region of the retina specialized for fine details called the 'fovea' whereas mice do not. However, researchers from the Netherlands Institute of Neuroscience have shown that the visual cortex of mice in fact contains a region of enhanced visual sensitivity - the 'focea'. This makes mice a better model for human vision than previously predicted.
The results can be read in Nature Communications: http://dx.doi.org/10.1038/s41467-021-24311-5
#sciencenews #biology #neuroscience
Nature Communications
Mouse visual cortex contains a region of enhanced spatial resolution
Nature Communications - The representation of space in mouse visual cortex was considered to be relatively uniform. The authors show that mice have improved visual resolution in a cortical region...
Molecular mechanisms in brain diseases.
Regulation of cellular proteins is crucial for maintaining a healthy brain. Rutgers University scientists have developed insights into how toxic proteins are regulated in neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases, which could help to design effective treatments in future.
The report has been published in PNAS: https://www.pnas.org/content/118/36/e2101410118/tab-article-info
#sciencenews #neuroscience #molecularbiology #biology
Regulation of cellular proteins is crucial for maintaining a healthy brain. Rutgers University scientists have developed insights into how toxic proteins are regulated in neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases, which could help to design effective treatments in future.
The report has been published in PNAS: https://www.pnas.org/content/118/36/e2101410118/tab-article-info
#sciencenews #neuroscience #molecularbiology #biology
PNAS
Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling
In neurodegenerative disease, protein aggregates spread to neighboring cells to promote pathology. The in vivo regulation of toxic material transfer remains poorly understood, although mechanistic understanding should reveal previously unrecognized therapeutic…