Sensitive coronavirus testing.
A new corona test developed at the University Hospital Bonn can simultaneously analyse a large number of swabs using sequencing technology and has a similarly high sensitivity to the common qPCR tests. The innovative method offers great potential for rapid systematic testing without the drawbacks of most methods.
The test is described in Nature Biotechnology: https://www.nature.com/articles/s41587-021-00966-9
#sciencenews #coronavirus #molecularbiology
A new corona test developed at the University Hospital Bonn can simultaneously analyse a large number of swabs using sequencing technology and has a similarly high sensitivity to the common qPCR tests. The innovative method offers great potential for rapid systematic testing without the drawbacks of most methods.
The test is described in Nature Biotechnology: https://www.nature.com/articles/s41587-021-00966-9
#sciencenews #coronavirus #molecularbiology
Nature
LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding
Nature Biotechnology - SARS-CoV-2 detection with LAMP-Seq combines isothermal amplification and barcoding with high-throughput sequencing.
Molecular mechanisms in brain diseases.
Regulation of cellular proteins is crucial for maintaining a healthy brain. Rutgers University scientists have developed insights into how toxic proteins are regulated in neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases, which could help to design effective treatments in future.
The report has been published in PNAS: https://www.pnas.org/content/118/36/e2101410118/tab-article-info
#sciencenews #neuroscience #molecularbiology #biology
Regulation of cellular proteins is crucial for maintaining a healthy brain. Rutgers University scientists have developed insights into how toxic proteins are regulated in neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases, which could help to design effective treatments in future.
The report has been published in PNAS: https://www.pnas.org/content/118/36/e2101410118/tab-article-info
#sciencenews #neuroscience #molecularbiology #biology
PNAS
Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling
In neurodegenerative disease, protein aggregates spread to neighboring cells to promote pathology. The in vivo regulation of toxic material transfer remains poorly understood, although mechanistic understanding should reveal previously unrecognized therapeutic…