Obesity, cancer and theranostics efficacy: challenges and opportunities
The rates of cancer seem to be inversely proportional to animal body size (Peto’s paradox; elephants <<<<< mice) mostly due to metabolic issues e.g. elephants have 20 copies of the TP53 gene while human very few.
The causal effect of body size and composition and risk of site-specific cancers in human studies is mixed.
Association between BMI and cancer survival in human studies: not consistent across cancer types and stages.
High BMI seems to be independently associated with improved survival in immunotherapy of patients with NSCLC.
It seems that there is decreased efficacy of cancer treatment among obese patients for some types of treatments, especially chemotherapy.
Little evidence indicating that weight loss for cancer patients would confer improved survival but did not take into account potential improvements in treatment efficacy.
It seems that increased physical activity may improve disease-free survival, with a potentially stronger impact among obese ones.
What about such issues in THERANOSTICS?
Think holistically, act moleculary
#cancertreatment
#theranostics
#molecularimaging
#obesity
#targetedtherapy
The rates of cancer seem to be inversely proportional to animal body size (Peto’s paradox; elephants <<<<< mice) mostly due to metabolic issues e.g. elephants have 20 copies of the TP53 gene while human very few.
The causal effect of body size and composition and risk of site-specific cancers in human studies is mixed.
Association between BMI and cancer survival in human studies: not consistent across cancer types and stages.
High BMI seems to be independently associated with improved survival in immunotherapy of patients with NSCLC.
It seems that there is decreased efficacy of cancer treatment among obese patients for some types of treatments, especially chemotherapy.
Little evidence indicating that weight loss for cancer patients would confer improved survival but did not take into account potential improvements in treatment efficacy.
It seems that increased physical activity may improve disease-free survival, with a potentially stronger impact among obese ones.
What about such issues in THERANOSTICS?
Think holistically, act moleculary
#cancertreatment
#theranostics
#molecularimaging
#obesity
#targetedtherapy
We proudly displayed a profound insight from the annals of ancient Persian literature on #Theranostics in our reception hall, penned by the venerable poet Hatef Esfahani in the 18th century.
Interpretation:
“Open the eye of the heart,
To behold that which eludes the gaze,
To perceive what lies beyond the sight,
And to comprehend what defies mortal expression.
Allow the inner eye to awaken,
Unveiling realms unseen by mortal eyes,
Discerning truths that surpass mere observation,
And attuning to the whispers that evade mortal ears.
In the realm of the heart's vision,
Glimpse the ethereal wonders that abound,
Hear the melodies that transcend earthly sound,
And witness the indescribable wonders of existence.
Let the eye of the heart be your guide,
For it holds the key to the unseen,
To the mysteries that lie beyond perception,
And to the beauty that transcends mortal description”.
Interpretation:
“Open the eye of the heart,
To behold that which eludes the gaze,
To perceive what lies beyond the sight,
And to comprehend what defies mortal expression.
Allow the inner eye to awaken,
Unveiling realms unseen by mortal eyes,
Discerning truths that surpass mere observation,
And attuning to the whispers that evade mortal ears.
In the realm of the heart's vision,
Glimpse the ethereal wonders that abound,
Hear the melodies that transcend earthly sound,
And witness the indescribable wonders of existence.
Let the eye of the heart be your guide,
For it holds the key to the unseen,
To the mysteries that lie beyond perception,
And to the beauty that transcends mortal description”.