Acute on Chronic Liver Failure From #Nonalcoholic Fatty #Liver Disease: A Growing and Aging Cohort With Rising Mortality
https://2medical.news/2021/04/03/acute-on-chronic-liver-failure-from-nonalcoholic-fatty-liver-disease-a-growing-and-aging-cohort-with-rising-mortality/
We assessed the burden of nonalcoholic fatty liver disease (NAFLD)‐related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. Approach and Results We analyzed the United Network for Organ Sharing registry from 2005 to 2017. Patients with ACLF were identified using the European Association for the Study of the Liver/Chronic Liver Failure criteria and …
https://2medical.news/2021/04/03/acute-on-chronic-liver-failure-from-nonalcoholic-fatty-liver-disease-a-growing-and-aging-cohort-with-rising-mortality/
We assessed the burden of nonalcoholic fatty liver disease (NAFLD)‐related acute on chronic liver failure (ACLF) among transplant candidates in the United States, along with waitlist outcomes for this population. Approach and Results We analyzed the United Network for Organ Sharing registry from 2005 to 2017. Patients with ACLF were identified using the European Association for the Study of the Liver/Chronic Liver Failure criteria and …
Dose-response association between #adiposity and #liver cancer incidence: a prospective cohort study among non-smoking and non-alcohol drinking Chinese women
https://2medical.news/2021/04/21/dose-response-association-between-adiposity-and-liver-cancer-incidence-a-prospective-cohort-study-among-non-smoking-and-non-alcohol-drinking-chinese-women/
Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at age 20, waist circumference (WC), hip circumference (HC), waist-to-hip ratio …
https://2medical.news/2021/04/21/dose-response-association-between-adiposity-and-liver-cancer-incidence-a-prospective-cohort-study-among-non-smoking-and-non-alcohol-drinking-chinese-women/
Background: Based on a population with very low prevalence of smoking and alcohol drinking, we examined the associations between overall obesity and fat distribution in middle age, obesity in early adulthood, and adult weight gain with the risk of liver cancer incidence. Methods: The associations between body mass index (BMI) at study enrollment and at age 20, waist circumference (WC), hip circumference (HC), waist-to-hip ratio …
Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes
https://2medical.news/2021/05/11/genetic-analysis-in-european-ancestry-individuals-identifies-517-loci-associated-with-liver-enzymes/
https://2medical.news/2021/05/11/genetic-analysis-in-european-ancestry-individuals-identifies-517-loci-associated-with-liver-enzymes/
2Medical.News
Genetic analysis in European ancestry individuals identifies 517 loci associated with #liver enzymes
Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline ph…
Development and prognostic relevance of a histologic grading and staging system for #alcohol-related #liver disease
https://2medical.news/2021/06/15/development-and-prognostic-relevance-of-a-histologic-grading-and-staging-system-for-alcohol-related-liver-disease/
https://2medical.news/2021/06/15/development-and-prognostic-relevance-of-a-histologic-grading-and-staging-system-for-alcohol-related-liver-disease/
2Medical.News
Development and prognostic relevance of a histologic grading and staging system for #alcohol-related #liver disease
The SALVE Histopathology Group (SHG) developed and validated a grading and staging system for the clinical and full histological spectrum of alcohol-related liver disease (ALD) and evaluated its pr…
All #coffee types decrease the risk of adverse clinical outcomes in chronic #liver disease: a UK Biobank study
https://2medical.news/2021/06/22/all-coffee-types-decrease-the-risk-of-adverse-clinical-outcomes-in-chronic-liver-disease-a-uk-biobank-study/
https://2medical.news/2021/06/22/all-coffee-types-decrease-the-risk-of-adverse-clinical-outcomes-in-chronic-liver-disease-a-uk-biobank-study/
2Medical.News
All #coffee types decrease the risk of adverse clinical outcomes in chronic #liver disease: a UK Biobank study
Chronic liver disease (CLD) is a growing cause of morbidity and mortality worldwide, particularly in low to middle-income countries with high disease burden and limited treatment availability. Coff…
#Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis
https://2medical.news/2021/06/30/statin-liver-safety-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-metanalysis/
https://2medical.news/2021/06/30/statin-liver-safety-in-non-alcoholic-fatty-liver-disease-a-systematic-review-and-metanalysis/
2Medical.News
#Statin liver safety in non-alcoholic fatty #liver disease. A systematic review and metanalysis
Statin liver safety in non-alcoholic fatty liver disease (NAFLD) patients is not well defined. We analysed differences in liver function tests, including alanine transaminase aminotransferase (ALT)…
Intact Fasting #Insulin Identifies Nonalcoholic Fatty #Liver Disease in Patients Without Diabetes
https://2medical.news/2021/07/10/intact-fasting-insulin-identifies-nonalcoholic-fatty-liver-disease-in-patients-without-diabetes/
https://2medical.news/2021/07/10/intact-fasting-insulin-identifies-nonalcoholic-fatty-liver-disease-in-patients-without-diabetes/
2Medical.News
Intact Fasting #Insulin Identifies Nonalcoholic Fatty #Liver Disease in Patients Without Diabetes
Patients with nonalcoholic fatty liver disease (NAFLD) are characterized by insulin resistance and hyperinsulinism. However, insulin resistance measurements have not been shown to be good diagnosti…
Incidence of #liver-related morbidity and mortality in a population cohort of non-alcoholic fatty liver disease
https://2medical.news/2021/07/11/incidence-of-liver-related-morbidity-and-mortality-in-a-population-cohort-of-non-alcoholic-fatty-liver-disease/
https://2medical.news/2021/07/11/incidence-of-liver-related-morbidity-and-mortality-in-a-population-cohort-of-non-alcoholic-fatty-liver-disease/
2Medical.News
Incidence of #liver-related morbidity and mortality in a population cohort of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) increases morbidity and mortality. However, patients in biopsy-based cohorts are highly selected and the absolute risks of liver- and non-liver outcomes in…
#EGFR activation limits the response of #liver cancer to lenvatinib
https://2medical.news/2021/07/23/egfr-activation-limits-the-response-of-liver-cancer-to-lenvatinib/
https://2medical.news/2021/07/23/egfr-activation-limits-the-response-of-liver-cancer-to-lenvatinib/
2Medical.News
#EGFR activation limits the response of #liver cancer to lenvatinib
Hepatocellular carcinoma (HCC)—the most common form of liver cancer—is an aggressive malignancy with few effective treatment options1. Lenvatinib is a small-molecule inhibitor of multiple receptor …
#Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of #Atherosclerosis, and Improves #Liver and Muscle Function in Low‐Density Lipoprotein Receptor–Deficient Mice
https://2medical.news/2021/09/14/cysteamine-decreases-low%E2%80%90density-lipoprotein-oxidation-causes-regression-of-atherosclerosis-and-improves-liver-and-muscle-function-in-low%E2%80%90density-lipoprotein-receptor-defi/
https://2medical.news/2021/09/14/cysteamine-decreases-low%E2%80%90density-lipoprotein-oxidation-causes-regression-of-atherosclerosis-and-improves-liver-and-muscle-function-in-low%E2%80%90density-lipoprotein-receptor-defi/
2Medical.News
#Cysteamine Decreases Low‐Density Lipoprotein Oxidation, Causes Regression of #Atherosclerosis, and Improves #Liver and Muscle…
We have shown previously that low‐density lipoprotein (LDL) can be oxidized in the lysosomes of macrophages, that this oxidation can be inhibited by cysteamine, an antioxidant that accumulates in l…
Synthesis of human #amyloid restricted to #liver results in an #Alzheimer disease–like neurodegenerative phenotype
https://2medical.news/2021/09/30/synthesis-of-human-amyloid-restricted-to-liver-results-in-an-alzheimer-disease-like-neurodegenerative-phenotype/
https://2medical.news/2021/09/30/synthesis-of-human-amyloid-restricted-to-liver-results-in-an-alzheimer-disease-like-neurodegenerative-phenotype/
2Medical.News
Synthesis of human #amyloid restricted to #liver results in an #Alzheimer disease–like neurodegenerative phenotype
Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an apolipoprotein…
Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease
https://2medical.news/2021/10/03/metabolic-associated-fatty-liver-disease-is-the-risk-factor-for-chronic-kidney-disease/
https://2medical.news/2021/10/03/metabolic-associated-fatty-liver-disease-is-the-risk-factor-for-chronic-kidney-disease/
2Medical.News
Metabolic associated fatty #liver disease is the risk factor for chronic #kidney disease
Background & AimsTo clarify the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and chronic kidney disease (CKD). MethodsThe participants were divided into fou…
High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis
https://2medical.news/2023/08/15/high-parathyroid-hormone-level-as-a-marker-of-non-alcoholic-fatty-liver-disease-and-non-alcoholic-steatohepatitis-a-systematic-review-and-meta-analysis/
https://2medical.news/2023/08/15/high-parathyroid-hormone-level-as-a-marker-of-non-alcoholic-fatty-liver-disease-and-non-alcoholic-steatohepatitis-a-systematic-review-and-meta-analysis/
2Medical.News
High #parathyroid hormone level as a marker of non-alcoholic #fatty #liver disease and non-alcoholic steatohepatitis: A systematic…
Highlights•Studies have shown that high PTH was associated with NAFLD/NASH, although the results from existing studies are inconsistent.•Using systematic review, 10 and 4 studies reported the assoc…
Association of nonalcoholic fatty #liver disease with #colorectal adenomatous #polyps and non-adenomatous polyps: a cross-sectional study
https://2medical.news/2023/09/14/association-of-nonalcoholic-fatty-liver-disease-with-colorectal-adenomatous-polyps-and-non-adenomatous-polyps-a-cross-sectional-study/
https://2medical.news/2023/09/14/association-of-nonalcoholic-fatty-liver-disease-with-colorectal-adenomatous-polyps-and-non-adenomatous-polyps-a-cross-sectional-study/
2Medical.News
Association of nonalcoholic fatty #liver disease with #colorectal adenomatous #polyps and non-adenomatous polyps: a cross-sectional…
Aim This study aimed to investigate the association between non-alcoholic fatty liver disease (NAFLD) and both colorectal adenomatous polyps and non-adenomatous polyps, in order to p…
Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
https://2medical.news/2023/09/29/detection-of-high-risk-polyps-at-screening-colonoscopy-indicates-risk-for-liver-and-biliary-cancer-death/
https://2medical.news/2023/09/29/detection-of-high-risk-polyps-at-screening-colonoscopy-indicates-risk-for-liver-and-biliary-cancer-death/
2Medical.News
Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Hepatobiliary cancers share risk factors with colorectal cancer (CRC), but there are no combined screening programs for these conditions.AimsThe aim of this study was to assess whether patients wit…
The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study
https://2medical.news/2023/11/21/the-potential-role-of-vitamin-e-in-managing-non-alcoholic-fatty-liver-disease-insights-from-japans-aichi-medical-university-study/
https://2medical.news/2023/11/21/the-potential-role-of-vitamin-e-in-managing-non-alcoholic-fatty-liver-disease-insights-from-japans-aichi-medical-university-study/
2Medical.News
The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University…
Non-Alcoholic Fatty Liver Disease (NAFLD) has emerged as a significant public health concern, affecting millions of individuals worldwide. Characterized by the accumulation of fat in the liver with…
ACG Clinical Guideline: #Alcohol-Associated #Liver Disease
https://2medical.news/2024/02/09/acg-clinical-guideline-alcohol-associated-liver-disease/
https://2medical.news/2024/02/09/acg-clinical-guideline-alcohol-associated-liver-disease/
2Medical.News
ACG Clinical Guideline: #Alcohol-Associated #Liver Disease
Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic disease and frequent indication for liver transplantation worldwide. With harmful alcohol use as the primary risk…
Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
https://2medical.news/2024/02/14/dietary-niacin-intake-and-mortality-among-individuals-with-nonalcoholic-fatty-liver-disease/
https://2medical.news/2024/02/14/dietary-niacin-intake-and-mortality-among-individuals-with-nonalcoholic-fatty-liver-disease/
2Medical.News
Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.Objective To examine the association of dieta…
Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
https://2medical.news/2024/03/18/dietary-niacin-intake-and-mortality-among-individuals-with-nonalcoholic-fatty-liver-disease-2/
https://2medical.news/2024/03/18/dietary-niacin-intake-and-mortality-among-individuals-with-nonalcoholic-fatty-liver-disease-2/
2Medical.News
Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Importance Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.Objective To examine the associat…
Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty #liver disease
https://2medical.news/2024/06/21/mitochondrial-acss1-k635-acetylation-knock-in-mice-exhibit-altered-metabolism-cell-senescence-and-nonalcoholic-fatty-liver-disease/
https://2medical.news/2024/06/21/mitochondrial-acss1-k635-acetylation-knock-in-mice-exhibit-altered-metabolism-cell-senescence-and-nonalcoholic-fatty-liver-disease/
2Medical.News
Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty #liver disease
Acetyl-CoA synthetase short-chain family member 1 (ACSS1) uses acetate to generate mitochondrial acetyl-CoA and is regulated by deacetylation by sirtuin 3. We generated an ACSS1-acetylation (Ac) mi…