Growing antibiotic #resistance forces updates to recommended treatment for #sexually transmitted infections
http://www.who.int/mediacentre/news/releases/2016/antibiotics-sexual-infections/en/
http://www.who.int/mediacentre/news/releases/2016/antibiotics-sexual-infections/en/
Peripheral modifications of Ψ[CH2NHTpg4] #vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics
http://m.pnas.org/content/early/2017/05/23/1704125114
In a quest for antibiotics that may display durable clinical lifetimes, analogs of the glycopeptide antibiotics, including vancomycin, have been designed that not only directly overcome the molecular basis of existing vancomycin #resistance but also contain two added peripheral modifications that endow them with two additional independent mechanisms of actions not found in the parent antibiotics. It is shown that such peripherally and binding pocket-modified vancomycin analogs display little propensity for acquired resistance by vancomycin-resistant Enterococci and that both their antimicrobial potency and durability against such challenges follow trends (three > two > one mechanisms of action) that are now predictable.
http://m.pnas.org/content/early/2017/05/23/1704125114
In a quest for antibiotics that may display durable clinical lifetimes, analogs of the glycopeptide antibiotics, including vancomycin, have been designed that not only directly overcome the molecular basis of existing vancomycin #resistance but also contain two added peripheral modifications that endow them with two additional independent mechanisms of actions not found in the parent antibiotics. It is shown that such peripherally and binding pocket-modified vancomycin analogs display little propensity for acquired resistance by vancomycin-resistant Enterococci and that both their antimicrobial potency and durability against such challenges follow trends (three > two > one mechanisms of action) that are now predictable.
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#Quinolone Consumption by Mothers Increases their Children’s Risk of Acquiring Quinolone-Resistant Bacteriuria
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz858/5556473?redirectedFrom=fulltext
Quinolone #resistance was detected in 2,182 (5.3%) of urine cultures. The median age was 5 years, with 93.7% females and 77.6% Jewish. A total of 26,937 (65%) of the children received any antibiotic and 1,359 (3.2%) of the mothers received quinolones in the 6 months preceding bacteriuria. Independent risk-factors were quinolone dispensed to the mothers [Odds Ratio (OR) 1.50, 95% Confidence Interval (CI) (1.22–1.85)], Arab ethnicity [OR 1.99, 95%CI (1.81–2.19)], and antibiotic dispensed to the child [OR 1.54 95%CI (1.38-1.71)]. Compared to children 12–17 years-of-age, younger children had 1.33-1.43 increased odds for quinolone-resistant bacteriuria.
Conclusions
Quinolones prescription to mothers was linked to increased risk of community-acquired quinolone-resistant bacteria in their offspring, by about 50%. This is another example of the deleterious ecological effects of antibiotic use and should be considered when prescribing antibiotics.
#Quinolone Consumption by Mothers Increases their Children’s Risk of Acquiring Quinolone-Resistant Bacteriuria
https://academic.oup.com/cid/advance-article-abstract/doi/10.1093/cid/ciz858/5556473?redirectedFrom=fulltext
Quinolone #resistance was detected in 2,182 (5.3%) of urine cultures. The median age was 5 years, with 93.7% females and 77.6% Jewish. A total of 26,937 (65%) of the children received any antibiotic and 1,359 (3.2%) of the mothers received quinolones in the 6 months preceding bacteriuria. Independent risk-factors were quinolone dispensed to the mothers [Odds Ratio (OR) 1.50, 95% Confidence Interval (CI) (1.22–1.85)], Arab ethnicity [OR 1.99, 95%CI (1.81–2.19)], and antibiotic dispensed to the child [OR 1.54 95%CI (1.38-1.71)]. Compared to children 12–17 years-of-age, younger children had 1.33-1.43 increased odds for quinolone-resistant bacteriuria.
Conclusions
Quinolones prescription to mothers was linked to increased risk of community-acquired quinolone-resistant bacteria in their offspring, by about 50%. This is another example of the deleterious ecological effects of antibiotic use and should be considered when prescribing antibiotics.
OUP Academic
Quinolone Consumption by Mothers Increases their Children’s Risk of Acquiring Quinolone-Resistant Bacteriuria
AbstractBackground. Quinolone resistance has been documented in the paediatric population, although their use is limited in children. This study investigated t
The effectiveness and safety of isometric #resistance training for adults with high blood #pressure: a systematic review and meta-analysis
https://2medical.news/2021/09/06/the-effectiveness-and-safety-of-isometric-resistance-training-for-adults-with-high-blood-pressure-a-systematic-review-and-meta-analysis/
https://2medical.news/2021/09/06/the-effectiveness-and-safety-of-isometric-resistance-training-for-adults-with-high-blood-pressure-a-systematic-review-and-meta-analysis/
2Medical.News
The effectiveness and safety of isometric #resistance training for adults with high blood #pressure: a systematic review and meta…
High blood pressure (BP) is a global health challenge. Isometric resistance training (IRT) has demonstrated antihypertensive effects, but safety data are not available, thereby limiting its recomme…
Incident Major #Depressive Disorder Predicted by Three Measures of Insulin #Resistance: A Dutch Cohort Study
https://2medical.news/2021/09/28/incident-major-depressive-disorder-predicted-by-three-measures-of-insulin-resistance-a-dutch-cohort-study/
https://2medical.news/2021/09/28/incident-major-depressive-disorder-predicted-by-three-measures-of-insulin-resistance-a-dutch-cohort-study/
2Medical.News
Incident Major #Depressive Disorder Predicted by Three Measures of Insulin #Resistance: A Dutch Cohort Study
Major depressive disorder is the leading cause of disability worldwide. Yet, there remain significant challenges in predicting new cases of major depression and devising strategies to prevent the d…