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Aldo Lorenzetti M.D, Internal Medicine & Hepatology, Milano - SIMEDET Delegate
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Effects of #Psilocybin-Assisted Therapy on Major #Depressive Disorder
https://2medical.news/2020/11/08/effects-of-psilocybin-assisted-therapy-on-major-depressive-disorder/

Major depressive disorder (MDD) is a substantial public health burden, but current treatments have limited effectiveness and adherence. Recent evidence suggests that 1 or 2 administrations of psilocybin with psychological support produces antidepressant effects in patients with cancer and in those with treatment-resistant depression.. ..Two psilocybin sessions (session 1: 20 mg/70 kg; session 2: 30 mg/70 kg) were given (administered in opaque gelatin capsules with …
#Lipoprotein (a) and the risk of elevated #depressive symptoms: The Multi-Ethnic Study of Atherosclerosis
https://2medical.news/2020/12/17/lipoprotein-a-and-the-risk-of-elevated-depressive-symptoms-the-multi-ethnic-study-of-atherosclerosis/

Previous studies suggested a potential relationship between plasma lipoprotein (a) [Lp(a)] and elevated depressive symptoms. We aimed to investigate any such relationship in the Multi-Ethnic Study of Atherosclerosis participants who were free of cardiovascular events. Analysis included 4938 participants without elevated depressive symptoms and with Lp(a) levels measured at baseline. Participants were examined at four clinic visits over a 10-year period. Elevated depressive symptoms were …
Association Between #Depressive Symptoms and Incident #Cardiovascular Diseases
https://2medical.news/2020/12/18/association-between-depressive-symptoms-and-incident-cardiovascular-diseases/

It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs).. ..Primary outcomes were incident fatal or nonfatal coronary heart disease (CHD), stroke, and CVD (composite of the 2). Hazard ratios (HRs) per 1-SD higher log CES-D or PHQ-2 adjusted for age, sex, smoking, and diabetes were reported. Results Among 162 036 participants from the ERFC (73%, women; mean age at …
Recurrence of major #depressive disorder and its predictors in the general population: results from The Netherlands Mental Health Survey and Incidence Study (NEMESIS)
https://2medical.news/2021/01/18/recurrence-of-major-depressive-disorder-and-its-predictors-in-the-general-population-results-from-the-netherlands-mental-health-survey-and-incidence-study-nemesis/

Knowledge of the risk of recurrence after recovery from major depressive disorder (MDD) in the general population is scarce. Method Data were derived from 687 subjects in the general population with a lifetime DSM-III-R diagnosis of MDD but without a current major depressive episode (MDE) or dysthymia. Participants had to be at least 6 months in remission, and were recruited from The Netherlands Mental Health …
Acute cognitive effects of single-dose intravenous #ketamine in major #depressive and posttraumatic stress disorder
https://2medical.news/2021/04/12/acute-cognitive-effects-of-single-dose-intravenous-ketamine-in-major-depressive-and-posttraumatic-stress-disorder/

Intravenous (IV) subanesthetic doses of ketamine have been shown to reduce psychiatric distress in both major depressive (MDD) and posttraumatic stress disorder (PTSD). However, the effect of ketamine on cognitive function in these disorders is not well understood. To address this gap, we examined the effect of a single dose of IV ketamine on cognition in individuals with MDD and/or PTSD relative to healthy controls …