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Education plus #exercise versus corticosteroid injection use versus a wait and see approach on global outcome and pain from gluteal #tendinopathy: prospective, single blinded, randomised clinical trial
https://www.bmj.com/content/361/bmj.k1662
..EDX had better global improvement scores than CSI (19.9% (4.7% to 35.0%); 5.0 (2.9 to 21.1)). At eight weeks, reported pain on the numerical rating scale was mean score 1.5 (standard deviation 1.5) for EDX, 2.7 (2.4) for CSI, and 3.8 (2.0) for WS. EDX and CSI participants reported less pain than WS (mean difference −2.2 (95% confidence interval −2.89 to −1.54); −1.2 (−1.85 to −0.50); respectively), and EDX participants reported less pain than CSI (−1.04 (−1.72 to −0.37)). Success on the global rating of change was reported at 52 weeks by 51/65 EDX, 36/63 CSI, and 31/60 WS participants; EDX was better than CSI (20.4% (4.9% to 35.9%); 4.9 (2.8 to 20.6)) and WS (26.8% (11.3% to 42.3%); 3.7 (2.4 to 8.8)). Reported pain at 52 weeks was 2.1 (2.2) for EDX, 2.3 (1.9) for CSI, and 3.2 (2.6) for WS; EDX did not differ from CSI (−0.26 (−1.06 to 0.55)), but both treatments did better than WS (1.13 (−1.93 to −0.33); 0.87 (−1.68 to −0.07); respectively).
Conclusions For gluteal tendinopathy, education plus exercise and corticosteroid injection use resulted in higher rates of patient reported global improvement and lower pain intens
Education plus #exercise versus corticosteroid injection use versus a wait and see approach on global outcome and pain from gluteal #tendinopathy: prospective, single blinded, randomised clinical trial
https://www.bmj.com/content/361/bmj.k1662
..EDX had better global improvement scores than CSI (19.9% (4.7% to 35.0%); 5.0 (2.9 to 21.1)). At eight weeks, reported pain on the numerical rating scale was mean score 1.5 (standard deviation 1.5) for EDX, 2.7 (2.4) for CSI, and 3.8 (2.0) for WS. EDX and CSI participants reported less pain than WS (mean difference −2.2 (95% confidence interval −2.89 to −1.54); −1.2 (−1.85 to −0.50); respectively), and EDX participants reported less pain than CSI (−1.04 (−1.72 to −0.37)). Success on the global rating of change was reported at 52 weeks by 51/65 EDX, 36/63 CSI, and 31/60 WS participants; EDX was better than CSI (20.4% (4.9% to 35.9%); 4.9 (2.8 to 20.6)) and WS (26.8% (11.3% to 42.3%); 3.7 (2.4 to 8.8)). Reported pain at 52 weeks was 2.1 (2.2) for EDX, 2.3 (1.9) for CSI, and 3.2 (2.6) for WS; EDX did not differ from CSI (−0.26 (−1.06 to 0.55)), but both treatments did better than WS (1.13 (−1.93 to −0.33); 0.87 (−1.68 to −0.07); respectively).
Conclusions For gluteal tendinopathy, education plus exercise and corticosteroid injection use resulted in higher rates of patient reported global improvement and lower pain intens
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Association of Efficacy of Resistance #Exercise Training With #Depressive Symptoms
Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2680311?redirect=true
The number needed to treat was 4. Total volume of prescribed RET, participant health status, and strength improvements were not significantly associated with the antidepressant effect of RET. However, smaller reductions in depressive symptoms were derived from randomized clinical trials with blinded allocation and/or assessment.
Conclusions and Relevance Resistance exercise training significantly reduced depressive symptoms among adults regardless of health status, total prescribed volume of RET, or significant improvements in strength. Better-quality randomized clinical trials blinding both allocation and assessment and comparing RET with other empirically supported treatments for depressive symptoms are needed
Association of Efficacy of Resistance #Exercise Training With #Depressive Symptoms
Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials
https://jamanetwork.com/journals/jamapsychiatry/article-abstract/2680311?redirect=true
The number needed to treat was 4. Total volume of prescribed RET, participant health status, and strength improvements were not significantly associated with the antidepressant effect of RET. However, smaller reductions in depressive symptoms were derived from randomized clinical trials with blinded allocation and/or assessment.
Conclusions and Relevance Resistance exercise training significantly reduced depressive symptoms among adults regardless of health status, total prescribed volume of RET, or significant improvements in strength. Better-quality randomized clinical trials blinding both allocation and assessment and comparing RET with other empirically supported treatments for depressive symptoms are needed
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How does #exercise treatment compare with antihypertensive medications? A network meta-analysis of 391 randomised controlled trials assessing exercise and medication effects on systolic blood #pressure
https://bjsm.bmj.com/content/early/2018/12/05/bjsports-2018-099921
In analyses that combined all populations, antihypertensive medications achieved higher reductions in baseline SBP compared with exercise interventions (mean difference −3.96 mmHg, 95% CrI −5.02 to −2.91). Compared with control, all types of exercise (including combination of endurance and resistance) and all classes of antihypertensive medications were effective in lowering baseline SBP. Among hypertensive populations, there were no detectable differences in the SBP-lowering effects of ACE-I, ARB, β-blocker and diuretic medications when compared with endurance or dynamic resistance exercise. There was no detectable inconsistency between direct and indirect comparisons. Although there was evidence of small-study effects, this affected both medication and exercise trials.
Conclusions The effect of exercise interventions on SBP remains under-studied, especially among hypertensive populations. Our findings confirm modest but consistent reductions in SBP in many studied exercise interventions across all populations but individuals receiving medications generally achieved greater reductions than those following structured exercise regimens. Assuming equally reliable estimates, the SBP-lowering effect of exercise among hypertensive populations appears similar to that of commonly used antihypertensive medications. Generalisability of these findings to real-world clinical settings should be further evaluated.
How does #exercise treatment compare with antihypertensive medications? A network meta-analysis of 391 randomised controlled trials assessing exercise and medication effects on systolic blood #pressure
https://bjsm.bmj.com/content/early/2018/12/05/bjsports-2018-099921
In analyses that combined all populations, antihypertensive medications achieved higher reductions in baseline SBP compared with exercise interventions (mean difference −3.96 mmHg, 95% CrI −5.02 to −2.91). Compared with control, all types of exercise (including combination of endurance and resistance) and all classes of antihypertensive medications were effective in lowering baseline SBP. Among hypertensive populations, there were no detectable differences in the SBP-lowering effects of ACE-I, ARB, β-blocker and diuretic medications when compared with endurance or dynamic resistance exercise. There was no detectable inconsistency between direct and indirect comparisons. Although there was evidence of small-study effects, this affected both medication and exercise trials.
Conclusions The effect of exercise interventions on SBP remains under-studied, especially among hypertensive populations. Our findings confirm modest but consistent reductions in SBP in many studied exercise interventions across all populations but individuals receiving medications generally achieved greater reductions than those following structured exercise regimens. Assuming equally reliable estimates, the SBP-lowering effect of exercise among hypertensive populations appears similar to that of commonly used antihypertensive medications. Generalisability of these findings to real-world clinical settings should be further evaluated.
British Journal of Sports Medicine
How does exercise treatment compare with antihypertensive medications? A network meta-analysis of 391 randomised controlled trials…
Objective To compare the effect of exercise regimens and medications on systolic blood pressure (SBP).
Data sources Medline (via PubMed) and the Cochrane Library.
Eligibility criteria Randomised controlled trials (RCTs) of angiotensin-converting enzyme…
Data sources Medline (via PubMed) and the Cochrane Library.
Eligibility criteria Randomised controlled trials (RCTs) of angiotensin-converting enzyme…
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Association of #Exercise Preconditioning With Immediate #Cardioprotection
https://jamanetwork.com/journals/jamacardiology/article-abstract/2664268
Preclinical evidence shows that 1 to 3 episodes of exercise per week will provide strong cardioprotection; gradual, modest cardiovascular risk factor modification or physiological artery remodeling cannot fully explain these benefits. This review highlights preclinical evidence that acute exercise-induced cardiac preconditioning has the ability to activate multiple pathways to confer immediate protection against ischemic events, reduce the severity of potentially lethal ischemic myocardiac injury, and act as a physiological first line of defense.
Conclusions and Relevance Independent of the protective benefits of long-term exercise training on risk factors and adaptation of the cardiovascular system, cardiovascular preconditioning may contribute to the immediate cardioprotection of exercise. In practical terms, this means that 1 episode of exercise can create clinically relevant cardioprotection.
Association of #Exercise Preconditioning With Immediate #Cardioprotection
https://jamanetwork.com/journals/jamacardiology/article-abstract/2664268
Preclinical evidence shows that 1 to 3 episodes of exercise per week will provide strong cardioprotection; gradual, modest cardiovascular risk factor modification or physiological artery remodeling cannot fully explain these benefits. This review highlights preclinical evidence that acute exercise-induced cardiac preconditioning has the ability to activate multiple pathways to confer immediate protection against ischemic events, reduce the severity of potentially lethal ischemic myocardiac injury, and act as a physiological first line of defense.
Conclusions and Relevance Independent of the protective benefits of long-term exercise training on risk factors and adaptation of the cardiovascular system, cardiovascular preconditioning may contribute to the immediate cardioprotection of exercise. In practical terms, this means that 1 episode of exercise can create clinically relevant cardioprotection.
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Positive Patient Response to a Structured #Exercise Program Delivered in Inpatient #Psychiatry
https://journals.sagepub.com/doi/10.1177/2164956119848657
The complexity of diagnostic presentations of an inpatient psychiatry population requires an integrative approach to health and well-being. In this sense, the primary need of this research aims at developing clinical strategies and healthier coping skills for anger, anxiety, and depression; promoting self-esteem, healthier sleep, and anxiety reduction; as well as enhancing mood and emotional–behavioral regulation via exercise and nutrition education..
The research yielded positive outcomes in all areas investigated, suggesting the positive effects of exercise and mind–body strategies in the context of psychotherapy in inpatient psychiatry.
Conclusion
Physical exercise may be a helpful way to reduce mental health disorders in the context of inpatient psychiatry by targeting anxiety, depression, anger, psychomotor agitation, and muscle tension and addressing stressors and triggers and to develop a more balanced and integrated sense of self.
Positive Patient Response to a Structured #Exercise Program Delivered in Inpatient #Psychiatry
https://journals.sagepub.com/doi/10.1177/2164956119848657
The complexity of diagnostic presentations of an inpatient psychiatry population requires an integrative approach to health and well-being. In this sense, the primary need of this research aims at developing clinical strategies and healthier coping skills for anger, anxiety, and depression; promoting self-esteem, healthier sleep, and anxiety reduction; as well as enhancing mood and emotional–behavioral regulation via exercise and nutrition education..
The research yielded positive outcomes in all areas investigated, suggesting the positive effects of exercise and mind–body strategies in the context of psychotherapy in inpatient psychiatry.
Conclusion
Physical exercise may be a helpful way to reduce mental health disorders in the context of inpatient psychiatry by targeting anxiety, depression, anger, psychomotor agitation, and muscle tension and addressing stressors and triggers and to develop a more balanced and integrated sense of self.
SAGE Journals
Positive Patient Response to a Structured Exercise Program Delivered in Inpatient Psychiatry
Open access Research article First published online May 21, 2019 All Articles https://doi.org/10.1177/2164956119848657
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#Exercise capacity and #body mass index - important predictors of change in resting #heart rate
Resting heart rate (RHR) is an obtainable, inexpensive, non-invasive test, readily available on any medical document. RHR has been established as a risk factor for cardiovascular morbidity, is related to other cardiovascular risk factors, and may possibly predict them. Change in RHR over time (∆RHR) has been found to be a potential predictor of mortality..
In this prospective study, RHR and ∆RHR were evaluated at baseline and over a period of 2.9 years during routine check-ups in 6683 subjects without known cardiovascular disease from the TAMCIS..
..RHR decreased with age, even after adjustment for sex, BMI and MET. The mean change in RHR was − 1.1 beats/min between two consecutive visits, in both men and women. This ∆RHR was strongly correlated with baseline RHR, age, initial MET, and change occurring in MET and BMI (P < 0.001).
Conclusions
Our results highlight the need for examining individual patients’ ∆RHR. Reinforcing that a positive ∆RHR is an indicator of poor adherence to a healthy lifestyle.
https://bit.ly/2sfOtoF
#Exercise capacity and #body mass index - important predictors of change in resting #heart rate
Resting heart rate (RHR) is an obtainable, inexpensive, non-invasive test, readily available on any medical document. RHR has been established as a risk factor for cardiovascular morbidity, is related to other cardiovascular risk factors, and may possibly predict them. Change in RHR over time (∆RHR) has been found to be a potential predictor of mortality..
In this prospective study, RHR and ∆RHR were evaluated at baseline and over a period of 2.9 years during routine check-ups in 6683 subjects without known cardiovascular disease from the TAMCIS..
..RHR decreased with age, even after adjustment for sex, BMI and MET. The mean change in RHR was − 1.1 beats/min between two consecutive visits, in both men and women. This ∆RHR was strongly correlated with baseline RHR, age, initial MET, and change occurring in MET and BMI (P < 0.001).
Conclusions
Our results highlight the need for examining individual patients’ ∆RHR. Reinforcing that a positive ∆RHR is an indicator of poor adherence to a healthy lifestyle.
https://bit.ly/2sfOtoF
BMC Cardiovascular Disorders
Exercise capacity and body mass index - important predictors of change in resting heart rate
Resting heart rate (RHR) is an obtainable, inexpensive, non-invasive test, readily available on any medical document. RHR has been established as a risk factor for cardiovascular morbidity, is related to other cardiovascular risk factors, and may possibly…
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Effects of #Caffeine and Acute Aerobic #Exercise on Working Memory and Caffeine Withdrawal
Studies show that a single bout of exercise confers cognitive benefits. However, many individuals use psychoactive substances such as caffeine to enhance cognitive performance..
The objectives of this study were to compare the effects of acute moderate intensity aerobic exercise to caffeine on working memory (WM) and caffeine withdrawal symptoms (CWS). In Phase I, non-caffeine (n = 29) and caffeine consumers (n = 30) completed a WM assessment, followed by acute exercise and caffeine.
In Phase II, caffeine consumers (n = 25) from Phase I underwent the WM assessment and reported CWS following a 12-hour deprivation period. Acute moderate intensity aerobic exercise and caffeine (1.2 mg/kg) significantly improved WM accuracy and reduced CWS comparably. WM performance was not reduced following caffeine deprivation..
https://go.nature.com/37KcXpg
Effects of #Caffeine and Acute Aerobic #Exercise on Working Memory and Caffeine Withdrawal
Studies show that a single bout of exercise confers cognitive benefits. However, many individuals use psychoactive substances such as caffeine to enhance cognitive performance..
The objectives of this study were to compare the effects of acute moderate intensity aerobic exercise to caffeine on working memory (WM) and caffeine withdrawal symptoms (CWS). In Phase I, non-caffeine (n = 29) and caffeine consumers (n = 30) completed a WM assessment, followed by acute exercise and caffeine.
In Phase II, caffeine consumers (n = 25) from Phase I underwent the WM assessment and reported CWS following a 12-hour deprivation period. Acute moderate intensity aerobic exercise and caffeine (1.2 mg/kg) significantly improved WM accuracy and reduced CWS comparably. WM performance was not reduced following caffeine deprivation..
https://go.nature.com/37KcXpg
Scientific Reports
Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal
Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal
Metabolic Architecture of Acute #Exercise Response in Middle-Aged Adults in the Community
https://2medical.news/2020/11/27/metabolic-architecture-of-acute-exercise-response-in-middle-aged-adults-in-the-community/
Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in humans.. ..We observed changes in circulating levels for 502 of 588 measured metabolites from rest to peak exercise (exercise duration 11.9±2.1 minutes) at a 5% …
https://2medical.news/2020/11/27/metabolic-architecture-of-acute-exercise-response-in-middle-aged-adults-in-the-community/
Whereas regular exercise is associated with lower risk of cardiovascular disease and mortality, mechanisms of exercise-mediated health benefits remain less clear. We used metabolite profiling before and after acute exercise to delineate the metabolic architecture of exercise response patterns in humans.. ..We observed changes in circulating levels for 502 of 588 measured metabolites from rest to peak exercise (exercise duration 11.9±2.1 minutes) at a 5% …
Dynamic changes in DICER levels in #adipose tissue control metabolic adaptations to #exercise
https://2medical.news/2020/12/21/dynamic-changes-in-dicer-levels-in-adipose-tissue-control-metabolic-adaptations-to-exercise/
DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing …
https://2medical.news/2020/12/21/dynamic-changes-in-dicer-levels-in-adipose-tissue-control-metabolic-adaptations-to-exercise/
DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing …
The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
https://2medical.news/2021/05/24/the-effects-of-aerobic-exercise-on-serum-biomarkers-of-neuroplasticity-and-brain-repair-in-stroke-a-systematic-review/
https://2medical.news/2021/05/24/the-effects-of-aerobic-exercise-on-serum-biomarkers-of-neuroplasticity-and-brain-repair-in-stroke-a-systematic-review/
2Medical.News
The Effects of Aerobic #Exercise on Serum Biomarkers of Neuroplasticity and Brain Repair in #Stroke: A Systematic Review
To provide a novel overview of the literature and to summarise the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in stroke survivors. Data S…
#Exercise training and resting blood #pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials
https://2medical.news/2023/07/29/exercise-training-and-resting-blood-pressure-a-large-scale-pairwise-and-network-meta-analysis-of-randomised-controlled-trials/
https://2medical.news/2023/07/29/exercise-training-and-resting-blood-pressure-a-large-scale-pairwise-and-network-meta-analysis-of-randomised-controlled-trials/
2Medical.News
#Exercise training and resting blood #pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials
Objective To perform a large-scale pairwise and network meta-analysis on the effects of all relevant exercise training modes on resting blood pressure to establish optimal antihypertensive exercise…
Effect of aerobic #exercise on #erectile function: systematic review and meta-analysis of randomized controlled trials
https://2medical.news/2023/11/03/effect-of-aerobic-exercise-on-erectile-function-systematic-review-and-meta-analysis-of-randomized-controlled-trials/
https://2medical.news/2023/11/03/effect-of-aerobic-exercise-on-erectile-function-systematic-review-and-meta-analysis-of-randomized-controlled-trials/
2Medical.News
Effect of aerobic #exercise on #erectile function: systematic review and meta-analysis of randomized controlled trials
The health benefits of regular aerobic exercise are well established, although there is limited high-quality evidence regarding its impact on erectile function.AimTo determine the effect of aerobic…
Effect of #Tai Chi vs Aerobic #Exercise on Blood #Pressure in Patients With PrehypertensionA Randomized Clinical Trial
https://2medical.news/2024/02/16/effect-of-tai-chi-vs-aerobic-exercise-on-blood-pressure-in-patients-with-prehypertensiona-randomized-clinical-trial/
https://2medical.news/2024/02/16/effect-of-tai-chi-vs-aerobic-exercise-on-blood-pressure-in-patients-with-prehypertensiona-randomized-clinical-trial/
2Medical.News
Effect of #Tai Chi vs Aerobic #Exercise on Blood #Pressure in Patients With PrehypertensionA Randomized Clinical Trial
Importance Prehypertension increases the risk of developing hypertension and other cardiovascular diseases. Early and effective intervention for patients with prehypertension is highly important.O…
Acute Vigorous #Exercise Decreases Subsequent Non-Exercise Physical Activity and Body Temperature Linked to #Weight Gain
https://2medical.news/2024/06/22/acute-vigorous-exercise-decreases-subsequent-non-exercise-physical-activity-and-body-temperature-linked-to-weight-gain/
https://2medical.news/2024/06/22/acute-vigorous-exercise-decreases-subsequent-non-exercise-physical-activity-and-body-temperature-linked-to-weight-gain/
2Medical.News
Acute Vigorous #Exercise Decreases Subsequent Non-Exercise Physical Activity and Body Temperature Linked to #Weight Gain
Purpose Exercise benefits the body and mind, but its weight loss effect is less than generally expected. Although this phenomenon is likely due to an exercise intensity-dependent decrease in non-ex…