Effect of Alternate-Day #Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy #Obese Adults
A Randomized Clinical Trial
http://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2623528

The primary outcome was change in body weight. Secondary outcomes were adherence to the dietary intervention and risk indicators for cardiovascular disease. There were no significant differences between the intervention groups in blood pressure, heart rate, triglycerides, fasting glucose, fasting insulin, insulin resistance, C-reactive protein, or homocysteine concentrations at month 6 or 12. Mean high-density lipoprotein cholesterol levels at month 6 significantly increased among the participants in the alternate-day fasting group (6.2 mg/dL 95% CI, 0.1-12.4 mg/dL), but not at month 12 (1.0 mg/dL 95% CI, –5.9 to 7.8 mg/dL), relative to those in the daily calorie restriction group. Mean low-density lipoprotein cholesterol levels were significantly elevated by month 12 among the participants in the alternate-day fasting group (11.5 mg/dL 95% CI, 1.9-21.1 mg/dL) compared with those in the daily calorie restriction group.

Conclusions and Relevance Alternate-day fasting did not produce superior adherence, weight loss, weight maintenance, or cardioprotection vs daily calorie restriction.

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Therapeutic use of intermittent #fasting for people with type 2 #diabetes as an alternative to insulin

http://casereports.bmj.com/content/2018/bcr-2017-221854

This case series documents three patients referred to the Intensive Dietary Management clinic in Toronto, Canada, for insulin-dependent type 2 diabetes. It demonstrates the effectiveness of therapeutic fasting to reverse their insulin resistance, resulting in cessation of insulin therapy while maintaining control of their blood sugars. In addition, these patients were also able to lose significant amounts of body weight, reduce their waist circumference and also reduce their glycated haemoglobin level.

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Effects of Intermittent #Fasting on Health, Aging, and Disease

Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to #ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.

https://bit.ly/369Na9v

Blood #Pressure Changes in 1610 Subjects With and Without Antihypertensive Medication During Long‐Term #Fasting
https://2medical.news/2020/12/08/blood-pressure-changes-in-1610-subjects-with-and-without-antihypertensive-medication-during-long%E2%80%90term-fasting/

We investigated daily blood pressure (BP) changes during fasting periods ranging from 4 to 41 (10.0±3.8) days in a cohort of 1610 subjects, including 920 normotensive, 313 hypertensive nonmedicated, and 377 hypertensive medicated individuals. Methods and Results Subjects underwent a multidisciplinary fasting program with a daily intake of ≈250 kcal. Weight and stress scores decreased during fasting, and the well‐being index increased, documenting a good …

#Diet-induced #fasting ghrelin elevation reflects the recovery of #insulin sensitivity and visceral adiposity regression

https://2medical.news/2021/10/20/diet-induced-fasting-ghrelin-elevation-reflects-the-recovery-of-insulin-sensitivity-and-visceral-adiposity-regression/

#Fasting-mimicking #diet causes hepatic and blood markers changes indicating reduced biological #age and disease risk

https://2medical.news/2024/02/22/fasting-mimicking-diet-causes-hepatic-and-blood-markers-changes-indicating-reduced-biological-age-and-disease-risk/