#Microscopic

#Diagnosis 👉🏻   Adrenocortecal carcinoma


#The_black_star
Invasion (Metastases to vein)

#The_blue_arrow
Hemorrhage

#The_features
- Encapsulated tumor 
- Invasion of thick fibrous capsule
- Lymphovascular invasion
- hemorrhage
- hyperchromic nuclei

NOTES
Often are functional and can lead to
- Cushing diseas
- Masculinization in females
- Feminization in male

#Microscopic

#Diagnosis 👉🏻   Phenochromocytoma


#The_black_star
Neoplasm

#The_black_arrows
intervening capillaries

#The_blue_arrow
sustentacular cells

#The_red_area
Zellballen ( nest )

#The_yellow_arrows
Vacuoles

#The_blue_star
Normal adrenal


#The_features
- Nested (zellballen) with adjacent smaller sustentacular cells surrounded by abundant intervening capillaries
- Cells: large, polygonal to spindle , uniform or extensively vacuolated
- Cytoplasm: abundant fine, granular red-purple cytoplasm
- Nuclei: central round to oval, nucleoli prominent

#Microscopic

#Diagnosis 👉🏻  Phenochromocytoma


#The_black_arrow
Phenochromocytoma
والتي تظهر باللون البني عند صبغها بصبغة S100 لانه ذي الصبغة تصبغ الادرينالين و النورادرينالين ويلي يكونوا في حاله افراز بشكل كبير

#The_blue_arrow
Adrenal cortex (negative)

#Microscopic

#Diagnosis 👉🏻  Phenochromocytoma


#The_black_arrow
Phenochromocytoma
والتي تظهر باللون البني عند صبغها بصبغة Chromogranin
وتظهر الانوية باللون الازرق

#The_blue_arrow
Adrenal cortex (negative)

#MICROSCOPIC

#Diagnosis 👉🏻 Cerebral infarct (Acute hypoxic-ischemic injury)
In first day


#The_black_arrows
Glial cells

#The_blue_arrows
Neurons
- Eosinphilic cytoplasm
- Shrinkage of the nucleus (pyknosis)

#Type_of_stain
HE
In ischemia the cells cytoplasm ➪ eosinphilic due to protein denaturation

#MICROSCOPIC

#Diagnosis 👉🏻 Cerebral infarct
1-3 days


#The_black_arrows
Neutrophils attack red neurons

#The_white_arrows
Neutrophils infiltration

#The_red_arrows
clusters of erythrocytes

#The_blue_arrows
Neurons without nucleus

#The_black_star
Cuff of neutrophils around and within Blood vessels

#MICROSCOPIC

#Diagnosis 👉🏻  Cerebral infarct
6-7 days


#The_black_arrows
Foamy macrophages

#MICROSCOPIC

#Diagnosis 👉🏻  Cerebral infarct
After twelfth day

#MICROSCOPIC

#Diagnosis 👉🏻 Herbes encephalitis


#The_blue_arrows
Lymphocyte

#The_white_arrows
Microglia

#the_red_area
Microglia nodule

#MICROSCOPIC

#Diagnosis 👉🏻  Herpes encephalitis


#The_white_arrow
Perivascular cuffs of lymphocyte

#MICROSCOPIC

#Diagnosis 👉🏻  Herpes encephalitis


#The_bule_arrows
Perivascular cuffs of lymphocyte

#MICROSCOPIC

#Diagnosis 👉🏻 syncytial meningioma


#The_black_arrows
Whorls of cells

#MICROSCOPIC

#Diagnosis 👉🏻 Psammomatous meningioma


#The_black_arrow
Meningothelial cells

#The_red_arrows
Psammoma bodies

#MICROSCOPIC

#Diagnosis 👉🏻 transitional meningioma

#The_black_arrow
Psammoma body

#The_blue_arrows
Fibrous

#The_red_arrow
Syncytial

#MICROSCOPIC

#Diagnosis 👉🏻 microcystic meningioma

#The_blue_arrow
Blood vessels hyalinosis

#MICROSCOPIC

#Diagnosis 👉🏻 chordoid meningioma


#The_black_arrow
Myxoid background

#The_blue_arrows
Cell arranged in chords

#The_white_areas
Mitosis

#MICROSCOPIC

#Diagnosis 👉🏻 clear cell meningioma


#The_black_arrows
Blood vessels (chicken wire)

#The_blue_arrows
Blocky collagen

#MICROSCOPIC

#Diagnosis 👉🏻 pilocytic astrocytoma
grade 1

#The_features
- bipolar cells (have processes extending form both ends
- mild hypercellularity
- hairy-like

#MICROSCOPIC

#Diagnosis 👉🏻 diffuse astrocytoma
grade 2


#The_red_arrow
mitosis

#The_features
- moderate hypercellularity
- mitosis
- little plemorphism
- fibillary (the hair-like processes are grouped to form the fibillary appearance)

#MICROSCOPIC

#Diagnosis 👉🏻 Metastatic melanoma

#Features
- malignant
- multifocal
- hyperchromatic nuclei
- plemorphism
- mitosis

#The_Red_arrows
Pigmentation (brown color)

#The_black_arrow
Normal brain tissue