🔴INTERACTION OF ASPIRIN🔴
➡️It inhibits the tubular secretions of uric acid and antagonize the action of probenecid.
➡️Aspirin blunts the diuretic action of furosemide and thiazide and reduce k+ conversion of spironolactone.
➡️ Aspirin displaces warfarin, sufonylureas, phenytoin and methotrexate from binding sites on plasms proteins.

🔴 Mechanism of Action 🔴

🔺Oral antidiabetic Drugs:-

🔸1. Sulfonylureas (K ATP channel blockers) & Meglitinide Or Phenilalanine analogues.

Sulfonylureas bind to Sulfonylurea receptor SUR1 on pancreatic beta cells membrane and provoke a brisk release of insulin. (Details given in below Fig.)

Meglitinide....... Also acts on SUR receptor closure to ATP sensitive potassium channels... depolarisation..... And finally insulin get released.

🔸2.Dipeptidyl peptidase4 inhibitors..... Indirectly acting secretagogues by preventing inactivation of GLP-1, GIP.

🔸3.Thiazolidinedione

Acts by enhancing the transcription of several insulin responsive genes.... Tends to reverse insulin resistance by enhancing GLUT4 expression and translocation.

🔸4. Alpha Glucosidase inhibitors.

Alpha Glucosidase is an enzyme located in brush border of small intestine & this is the final enzyme for the digestion of carbohydrates.

Inhibitors of this enzyme simply inhibit it... And there is slow down of degradation of carbohydrates and polysaccharides and Sucrose.... And less glucose get absorbed and blood glucose level get near to normal.

🔸5. Dopamine D2 agonist... Bromocriptine... Reset the insulin resistance.

🔸6.Sodium glucose co-transport-2 (SGLT-2) inhibitor.

SGLT2 transporter inhibition causes induction glucosuria and lowers blood glucose .

🔴ADRS OF INSULIN🔴
➡️Hypoglycemia
➡️Local reactions
➡️Allergy
➡️Edema

🔴ADRS OF SULFONYLUREAS🔴
➡️Hypoglycemia
➡️Nonspecific side effects as like nausea,vomiting, diarrhea, headache.
➡️Hypersensitivity reactionsas like rashes, Photosensitivity, flushing,and disulfiram like reactions.