Health Research Stories
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We share inside stories from high-quality and impactful health research. Validate the evidence: https://zheln.com
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When someone asks me what I do, and I reply with something like ‘I’m an evidence synthesis researcher,’ they are usually having a hard time understanding that. It need not be this way. In fact, knowledge synthesis is something everybody does every day of their lives. [Thread] 👇 https://threadreaderapp.com/thread/1617772138529959938.html
Eight months ago, an important study was out, with its results relevant for 200 million people, but went largerly unnoticed. Wut? Zheln finds out👇 Thread #1
The International Olympic Committee recognized beetroot as a potent performance booster, among other nitrate supplements. Everybody else claims beetroot is “powerful” stuff to take before exercise. Is it? Zheln collected and appraised current research using @WriteInStonePublic and found no ground for such optimism, even though there are data from dozens of trials that might come useful in specific contexts. Watch popular internet claims smash against evidence: https://zheln.com/thread/2023/12/28/1/
No evidence cranberry juice is helpful for urinary infections in pregnancy, multiple studies find.

There is a mild preventative effect among children and non-pregnant women with recurrent UTIs ­– but those findings are still provisional. Learn the evidence feat. a @WriteInStonePublic video bibliography.
Channel name was changed to «Zheln Health Evidence»
Channel name was changed to «Evidence-based Health News»
Channel name was changed to «Health News & Evidence»
Channel name was changed to «Health Research Stories»
How can doctors know which cancer treatment is better? One way is by riding slugs.

Learn how and pick the best cancer treatment option based on bleeding-edge scientific evidence from human trials: https://zheln.com/thread/2024/01/11/1/

If you feel critical about this post, we invite you to review its video bibliography, captured with @WriteInStonePublic, and drop any criticisms in the comments. Pavel Zhelnov, MD, will address all valid concerns and acknowledge the peer reviewers in the following Zheln post. We look forward to reading your messages.
Tamiflu is a widely advertised anti-flu drug that failed to show dramatic effects in clinical trials. Powered by @WriteInStonePublic, we revisit the evidence in light of a major 2023 meta-analysis and argue why highlighing failures might be as important as distilling benefits.
Seatbelt promotion works, but how well? 60% of drivers still don’t use seat belts, and even more passengers. Tracking steps with @WriteInStonePublic software, we discuss a recent systematic review that looked at the effectiveness of seat-belt promotion more closely.
Gentle human touch was shown to reduce pain in newborn babies. A new systematic review found that neonates do suffer from airway suctioning, but careful positioning likely alleviates pain. How did researchers measure it? Follow our steps using @WriteInStonePublic in a new Zheln post.
Zheln’s (impolite) take on hazard vs. risk and some pieces of health research – and their authoritative academic publishers – that still fail to use a comprehensive search strategy in a systematic review and overlook the existence of ROBINS-E in 2024: https://hey.xyz/posts/0x04fcbd-0x09-DA-2c9ba1a1
Dipeptidyl peptidase-4 (DPP4) inhibitors do not work.

The market share is US$ 11.6 billion.

They are not effective at all, with high certainty.

DPP4 inhibitors are one of the newer drugs people with type 2 diabetes use to lower their blood sugar levels. They include medications such as Januvia (sitagliptin), Onglyza (saxagliptin), Tradjenta (linagliptin), Nesina or Vipidia (alogliptin), and Galvus (vildagliptin).

Objections?

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Probiotics won’t make you poop, but lactulose will, with moderate certainty.

Taking lactulose for an average of 4 weeks leads to at least one more additional stool per week in adults with positive Rome criteria for constipation.

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