#quiz
#رفح_تحت_القصف 🇵🇸

تفريغ د عبد المتعال فودة

ANS
Part1: Beta adrenergic blockers

By Dr Maymounah
"من إستفاد فلا ينسى الشهيد أبو آية بدعوة صادقة"

#Pharmacy

#Neurology

#Tafreghat

#رفح_تحت_القصف  🇵🇸

تفريغ د عبد المتعال فودة

ANS
Part2: beta adrenergic blockers

By Dr Maymounah
"من إستفاد فلا ينسى الشهيد أبو آية بدعوة صادقة"

#Pharmacy

#Neurology

#Tafreghat

#رفح_تحت_القصف  🇵🇸

إيه الفرق بين
Thalassemia vs iron deficiency anemia?

### Thalassemia:
🔹 Genetic Disorder:
- Thalassemia is primarily a genetic disorder caused by mutations in the genes responsible for hemoglobin production.

🔹 Reduced Hemoglobin Synthesis:
- Individuals with thalassemia have reduced synthesis of hemoglobin, leading to fewer healthy red blood cells.

🔹 Inherited Condition:
- Thalassemia is inherited from parents who carry mutated genes related to hemoglobin production.

🔹 Chronic Anemia:
- It causes chronic anemia, which can range from mild to severe depending on the type and number of affected genes.

🔹 Treatment Options:
- Treatment may involve blood transfusions, iron chelation therapy, and, in some cases, bone marrow transplantation.

### Iron Deficiency Anemia:
🔸 Iron Deficiency:
- Iron deficiency anemia results from inadequate iron levels in the body, leading to decreased hemoglobin production.

🔸 Multiple Causes:
- Causes include insufficient dietary intake of iron, poor absorption of iron, blood loss (chronic or acute), or increased iron requirements.

🔸 Common Nutritional Deficiency:
- It is one of the most common nutritional deficiencies worldwide.

🔸 Treatment with Iron Supplements:
- Treatment involves iron supplementation, dietary changes to include iron-rich foods, and addressing underlying causes like gastrointestinal bleeding or menstrual disorders.

🔸 Reversible Condition:
- Iron deficiency anemia is often reversible with proper treatment and addressing the underlying cause.

📚 Reference ➡️ Pubmed

#PDFology
#رفح_تحت_القصف 🇵🇸

#quiz
#رفح_تباد 🇵🇸

Nutrient Depletion due to Medications

#رفح_تباد 🇵🇸

💊 علاج للضغط كل ست شهور!

📋 Zilebesiran is an exciting new drug currently under development for the treatment of hypertension (high blood pressure). Here's a breakdown of the key details:

🔍 What it is:

* Zilebesiran is an investigational RNA interference (RNAi) therapeutic. RNAi is a technology that can silence specific genes.
* In this case, zilebesiran targets the gene for angiotensinogen, a protein involved in regulating blood pressure. By reducing angiotensinogen levels, zilebesiran aims to lower blood pressure.

🛠️ How it works:

* Zilebesiran is delivered subcutaneously, meaning it's injected under the skin.
* It utilizes a specific technology called ESC+ GalNAc-conjugate, which allows for infrequent dosing (potentially twice-yearly or quarterly).
* Early studies suggest a single dose can effectively reduce blood pressure for up to six months.

📊 What the research shows:

* Phase 2 clinical trials have shown promise. A single dose of zilebesiran significantly lowered both systolic and diastolic blood pressure for up to 24 weeks in people with mild-to-moderate hypertension.
* The reduction in blood pressure was consistent throughout the day and night, which is important for optimal blood pressure control.
* The study also found zilebesiran to be well-tolerated, with only mild injection site reactions reported.

⚠️ Important things to note:

* Zilebesiran is still under development, and further studies are needed to confirm its efficacy and safety in larger populations.
* It's not yet available for prescription.
* If you have high blood pressure, it's crucial to consult with your doctor about the best treatment options for you.

🌐 Reference ➡️ Pubmed

#PDFology

#رفح_تحت_القصف 🇵🇸

🚨 اعلانات التلجرام تظهر بشكل إجباري ولا يمكن إلغائها فضلاً عمل ريبورت لأي إعلان قد يظهر به شبهة حرمانية 🚨

تفريغ د عبد المتعال فودة CNS

Lecture: 11
Antidepressant drugs

By Dr Maymounah
"من إستفاد فلا ينسى الشهيد أبو آية بدعوة صادقة"

#Pharmacy

#Neurology

#Tafreghat

#رفح_تحت_القصف 🇵🇸

إيه الفرق بين
Ezetimibe 🆚 Statins?

🔬 Mechanism of Action:

* Ezetimibe: Acts as a cholesterol absorption inhibitor, specifically targeting Niemann-Pick C1 Like 1 (NPC1L1) protein in the small intestine.
This reduces dietary cholesterol uptake.
* Statins: Function as HMG-CoA reductase inhibitors, acting within the liver to decrease cholesterol synthesis.

📉 LDL-C Reduction:

* Ezetimibe: Provides a modest reduction of LDL-C (low-density lipoprotein cholesterol) by 15-22%.
* Statins: Offer a more potent effect, lowering LDL-C by 30-50%.

⚕️ Clinical Use:

* Ezetimibe: May be used as monotherapy for mild hypercholesterolemia or in combination therapy with statins for patients requiring a more aggressive LDL-C reduction strategy.
* Statins: Represent the first-line treatment for lowering LDL-C due to their efficacy.

💊 Side Effect Profile:

* Ezetimibe: Generally well-tolerated with minimal adverse effects reported.
* Statins: May be associated with muscle aches, fatigue, and, in rare cases, liver dysfunction.

🤔 Considerations for Selection:

* Individual risk factors for cardiovascular disease.
* Baseline LDL-C levels.
* Patient tolerability to medications.

🔚 Conclusion:

Both ezetimibe and statins play a role in managing cholesterol levels. Statins offer a more robust LDL-C reduction, making them the preferred initial therapy.
Ezetimibe serves as a valuable tool for patients with statin intolerance or those requiring additional LDL-C lowering alongside a statin regimen.
The optimal choice depends on individual patient characteristics and should be determined in consultation with a physician.

#PDFology

#Vs

#رفح_الان 🇵🇸

تفريغ أدوية السكر د طارق المقطري

#Pharmacy

#Endocrine

#Tafreghat

#رفح_الان 🇵🇸

قال أبي سعيد الخدري رضي الله عنه: قال رسول الله صلى الله عليه وسلم: من قرأ سورة الكهف في يوم الجمعة، أضاء له من النور ما بين الجمعتين. رواه الحاكم والبيهقي وصححه الألباني.

﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]

اللهم إنا نستودعك غزة وأهلها، اللَّهُم كُن لهم عونًا ومعينا، اللهم إنا لا نملك لغزة إلا الدعاء فيارب لا ترد لنا دعاء، ولا تخيب لنا رجاء وأنت أرحم الراحمين.

اللهم احفظ فلسطين وأهلها اللهم كن لأهلنا هناك عونا ومعينا، وللمسجد الاقصي حافظا وأمينا، اللهم إنا نستودعك غزة فأحفظها بحفظك يا خير الحافظين.

#رفح 🇵🇸

تفريغ د عبد المتعال فودة CNS

Lecture:12
Alzheimer disease

By Dr Maymounah
"من إستفاد فلا ينسى الشهيد أبو آية بدعوة صادقة"

#Pharmacy

#Neurology

#Tafreghat

#رفح 🇵🇸

تفريغ د عبد المتعال فودة CNS

Lecture from 1️⃣ to 1️⃣2️⃣

By Dr Maymounah
"من إستفاد فلا ينسى الشهيد أبو آية بدعوة صادقة"

#Pharmacy

#Neurology

#Tafreghat

#رفح 🇵🇸

#quiz

#رفح 🇵🇸

تفريغ د عبد المتعال فودة Blood

Lecture:1
Anticoagulant drugs

By Dr Maymounah
"من إستفاد فلا ينسى الشهيد أبو آية بدعوة صادقة"

#Pharmacy

#Hematology

#Tafreghat

#رفح 🇵🇸

قال أبي سعيد الخدري رضي الله عنه: قال رسول الله صلى الله عليه وسلم: من قرأ سورة الكهف في يوم الجمعة، أضاء له من النور ما بين الجمعتين. رواه الحاكم والبيهقي وصححه الألباني.

﴿ إِنَّ اللَّهَ وَمَلَائِكَتَهُ يُصَلُّونَ عَلَى النَّبِيِّ ۚ يَا أَيُّهَا الَّذِينَ آمَنُوا صَلُّوا عَلَيْهِ وَسَلِّمُوا تَسْلِيمًا﴾
[ الأحزاب: 56]

اللهم إنا نستودعك غزة وأهلها، اللَّهُم كُن لهم عونًا ومعينا، اللهم إنا لا نملك لغزة إلا الدعاء فيارب لا ترد لنا دعاء، ولا تخيب لنا رجاء وأنت أرحم الراحمين.

اللهم احفظ فلسطين وأهلها اللهم كن لأهلنا هناك عونا ومعينا، وللمسجد الاقصي حافظا وأمينا، اللهم إنا نستودعك غزة فأحفظها بحفظك يا خير الحافظين.

#رفح 🇵🇸