"Polyethylene glycol (PEG)-coated nanopharmaceuticals can cause mild to severe hypersensitivity reactions (HSRs), which can occasionally be life threatening or even lethal. The phenomenon represents an unsolved immune barrier to the use of these drugs, yet its mechanism is poorly understood. This study showed that a single i.v. injection in pigs of a low dose of PEGylated liposomes (Doxebo) induced a massive rise of anti-PEG IgM in blood, peaking at days 7–9 and declining over 6 weeks. Bolus injections of PEG-liposomes during seroconversion resulted in anaphylactoid shock (pseudo-anaphylaxis) within 2–3 min, although similar treatments of naı̈ve animals led to only mild hemodynamic disturbance. Parallel measurement of pulmonary arterial pressure (PAP) and sC5b-9 in blood, taken as measures of HSR and complement activation, respectively, showed a concordant rise of the two variables within 3 min and a decline within 15 min, suggesting a causal relationship between complement activation and pulmonary hypertension. We also observed a rapid decline of anti-PEG IgM in the blood within minutes, increased binding of PEGylated liposomes to IgM+ B cells in the spleen of immunized animals compared to control, and increased C3 conversion by PEGylated liposomes in the serum of immunized pigs. These observations taken together suggest rapid binding of anti-PEG IgM to PEGylated liposomes, leading to complement activation via the classical pathway, entailing anaphylactoid shock and accelerated blood clearance of liposome–IgM complexes. These data suggest that complement activation plays a causal role in severe HSRs to PEGylated nanomedicines and that pigs can be used as a hazard identification model to assess the risk of HSRs in preclinical safety studies."
https://pubs.acs.org/doi/10.1021/acsnano.9b03942

Watch Is it True that the New Variants are Very Dangerous?
https://vimeo.com/507658201

"Dear Editor
History is littered with examples of the atrocities which ensue when doctors abandon their traditional principles and judgement in favour of unquestioning subservience to government diktat – medical involvement in torture, human experimentation and psychiatric punishment of political dissidents being familiar examples.
Abbasi takes as axiomatic that there was no prior immunity in the population, that lockdowns are effective, that computer modelling is realistic, that statistics have been accurate and that WHO statements are reliable. All of these parameters have been widely challenged by knowledgeable and conscientious researchers whose findings were often disregarded, censored or vilified.
From a medical perspective, it was clear early on in the crisis that disregarding clinical acumen in favour of blind obedience to abnormal ventilation measures, reliance on an unsuitable laboratory test for diagnosis and management, and abandoning the duty of care to elderly hospitalised patients and those awaiting diagnosis and treatment of serious diseases, would create severe problems down the line.
Doctors who had empirically found effective pharmaceutical remedies and preventative treatments were ignored, or worse, denigrated or silenced. Information regarding helpful dietary supplements was suppressed.
This was further compounded by rule-changes to death certification, coroners’ instructions, autopsy guidelines, DNR notices and the cruel social isolation policy enforcement regarding family visits to the sick and dying.
When medical professionals allow themselves to be manipulated by corrupt politicians and influenced by media propaganda instead of being guided by their own ethical principles and common sense based on decades of clinical experience, the outlook becomes very bleak indeed.
Historically, public respect for and trust in doctors has exceeded that awarded to politicians. The unquestioning capitulation of medicine to an authoritarian executive and predatory corporate power may have undermined the doctor-patient relationship for a generation." Janet Menage, GP, retired
https://www.bmj.com/content/372/bmj.n314/rr-8

Mike Yeadon: "Robin, I’ve just spent over an hour reading (some of) this wonderful paper! They find several HUNDRED different T-cell epitopes, which don’t correlate particularly well with epitopes targeted by antibodies. The huge T-cell repertoire is not only very reassuring in relation to avoiding immune escape via mutations (which are very slight in proportion to the FL virus sequences) but the lack of correlation to antibody epitopes strongly supports NOT basing policy on whether or not a variant is bound more or less well by a specific antibody.
As previously discussed, this is an exceptionally large virus, affording a large number of sequences recognised by T-cells as unique & foreign. This isn’t surprising. What is surprising is just how concerned some presumably non immunologists are with trivial extents of variation."
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(21)00015-X#%20

On the seasonality of coronaviruses. All going like clockwork I would say. Thanks Dr Simon t.me/goddek

The percentage of tests positive for human coronaviruses (HCoVs) -OC43, -NL63, -229E, and -HKU1 reported to the National Respiratory and Enteric Viruses Surveillance System (NREVSS) by week, stratified by US Census Region, July 2014–June 2017.
https://pubmed.ncbi.nlm.nih.gov/29427907/

Age distribution of human coronaviruses (HCoVs) -229E, -HKU1, -NL63 & -OC43 positive tests with age available reported to NREVSS via the Public Health Laboratory Interoperability Project (PHLIP), from July 2014–June 2017. Specimens with more than one coronavirus detected excluded
https://pubmed.ncbi.nlm.nih.gov/29427907/

Take a look at human coronavirus OC43. This can be as deadly if untreated for older people as SARSCoV2. We have always had it. There has never been a huge deal made about it. "These findings underscore the virulence of human CoV-OC43 [endemic common cold coronavirus] in elderly populations" out of 95 infections, 8 died (8% mortality rate, 92% survival rate), 6 with pneumonia.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095096/

"In OECD countries. the mortality rate for SARS-CoV-2..is not significantly different from that for common coronaviruses identified in public hospitals of Marseille, France (0.8%)."
https://www.sciencedirect.com/science/article/abs/pii/S0924857920300972

Watch (ENG) OVALexclusive : Urgent Message from Prof. Sucharit Bhakdi
https://vimeo.com/507137123

‘German ministry hired scientists to induce corona fear’
https://netherlandsnewslive.com/german-ministry-hired-scientists-to-induce-corona-fear/84131/

IMATH hoslitalization protocol explainer of Covid19 disease stages
https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf

However it's missing the macrolids: "Therapeutic efficacies of macrolids in patients with mild COVID-19 compared to standard supportive therapy
There was significant shorter duration of fever (days), in patients treated with either azithromycin (5.2 ± 2.3) or clarithromycin (4.9 ± 1.5) compared to control group (12.9 ± 2.2), P < 0.000. Duration of cough also showed significant fewer days for improvment in patients treated with either azithromycin (5.4 ± 2.7) or clarithromycin (5.1 ± 2) compared to control group (12.9 ± 2.2) P < 0.0001, in addition, dyspnea duration (days) showed significant early improvement in patients treated with either Azithromycin (4.6 ± 3.3) or Clarithromycin (4.7 ± 2.9) compared to control group (9.3 ± 2.7) ,P < 0.0001 (Table 2). There was significant early conversion (days) of SARS-CoV-2 PCR to negative in patients treated with either azithromycin (8.7 ± 2.8) or clarithromycin (8.3 ± 2.6) compared to control group (13.2 ± 4.2), P < 0.0001 (Table 2)."
https://www.researchsquare.com/article/rs-181996/v1"

IMASK prophylaxis & early outpatient protocols
https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf

According to extensive email exchanges obtained by a group of lawyers in a legal dispute, the German Interior Ministry hired scientists to develop fake coronavirus model in order to justify strict lockdown.

https://greatgameindia.com/germany-hired-scientists-fake-coronavirus-model/

"Regarding the question as to whether children themselves complain about impairments caused by wearing the mask, 67.7% of the respondents answered yes for their children; 26% answered no. The question as to whether the respondents themselves observed an impairment of the child by wearing the mask was answered yes in 66.1%"
https://www.researchsquare.com/article/rs-124394/v2

UK Vaccine Network
Membership
The UK Vaccine Network is made up of leading experts from academia, industry and policy. All members are invited to join the Network in a personal capacity, not as representatives of specific organisations or bodies.
Chair
Chris Whitty, Chief Scientific Adviser to the Department of Health and Social Care
https://www.gov.uk/government/groups/uk-vaccines-network#membership

“The Book of Vision”: Indie auteur Terrence Malick serves as executive producer for this heady, cerebral quasi-period piece that plunges a questioning doctor/student (Lotte Verbeek) into the unorthodox 18th century practices and thoughts of a physician (Charles Dance). Malick’s participation means the cinematography is a standout in documentary filmmaker Carlo S. Hintermann’s ambitious first feature foray. This intriguing talker is the festival’s opening night selection.
https://localnewsmatters.org/2021/02/04/pass-the-remote-must-see-adventurous-selections-at-the-online-sf-independent-film-festival/