Neurotropism of SARS-CoV 2: Mechanisms and manifestations:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141641/
"Respiratory involvement is the most common in patients confirmed with Covid-19, however there are already reports of neurological manifestations [2,3]. It should be mencioned that the central nervous system (CNS) involvement was also reported in other coronaviruses [4] and studies in humans and experimental models revealed a possible neural pathway given by the olfactory nerve [[5], [6], [7]].
Viruses can reach the CNS through hematogenous or neural propagation [8]. Nerve dissemination is possible by the polarization of neurons, this property gives them the ability to receive and transfer information. This transport can be retrograde or antegrade and is facilitated by proteins called dinein and kinesin, which can be targets of viruses [9]. Once entered the CNS, viruses can generate alterations in neurons, as evidenced by a study carried out by Gu et al., who detected in 8 autopsies of victims of SARS, neuronal histopathological changes in the cortex and hypothalamus [6].
The olfactory pathway begins in bipolar cells located in the olfactory epithelium, from there its axons and dendrites extend to the olfactory bulb, where they make synapses with the cells present in this structure. Subsequently, this cranial pair is divided into two branches and is directed towards the olfactory nucleus present in the pyriform cortex [10] . This nerve route has been used by some coronaviruses in rodent models exposed to nasal inoculation [11,12].
Similar results were found in a Canadian study with another coronavirus, HCoV-OC43. In this case, by the fourth day of inoculation, the virus had already spread to the piriformis cortex, brain stem, and spinal cord [12].
The interesting thing about this possible propagation mechanism is the presence of the virus in areas of the brain stem [11,12], because this structure contains nuclei that regulate the respiratory rhythm. Breathing has central control given by the regulation of a number of neural groups. Through the nucleus of the solitary fascicle, the CNS receives information from the chemoreceptors that detect changes in the concentrations of CO2 and O2, alterations in these components lead to an increase or decrease in respiratory effort [13]. In this way, stem nuclei have connections with the respiratory system [1,13], and the entry of the coronavirus into this structure could trigger death by alteration of these neuronal groups [1].
In their analysis they found that 36.4% of the patients had neurological symptoms, these being directly related to the severity of the patient (severe cases VS non-severe: 40 [45.5%] vs. 38 [30.2%], P < .05). In patients with central symptoms (24.8%), 16.8% and 13.1% presented dizziness and headache, respectively. Among the peripheral symptoms (8.9%), the most common were hypogeusia and hyposmia with 5.6 and 5.1%.
"Zhou et al., detected the presence of the virus genome in the CSF [CerebroSpinal Fluid] of a 59-year-old patient with COVID-19 pneumonia, diagnosing viral encephalitis, demonstrating the direct damage that the virus produces in the CNS [Central Nervous System] [16]
The aforementioned makes us think that respiratory distress is not only the result of pulmonary inflammatory structural damage, but also due to the damage caused by the virus in the respiratory centers of the brain, making it more difficult to manage these patients."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141641/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141641/
"Respiratory involvement is the most common in patients confirmed with Covid-19, however there are already reports of neurological manifestations [2,3]. It should be mencioned that the central nervous system (CNS) involvement was also reported in other coronaviruses [4] and studies in humans and experimental models revealed a possible neural pathway given by the olfactory nerve [[5], [6], [7]].
Viruses can reach the CNS through hematogenous or neural propagation [8]. Nerve dissemination is possible by the polarization of neurons, this property gives them the ability to receive and transfer information. This transport can be retrograde or antegrade and is facilitated by proteins called dinein and kinesin, which can be targets of viruses [9]. Once entered the CNS, viruses can generate alterations in neurons, as evidenced by a study carried out by Gu et al., who detected in 8 autopsies of victims of SARS, neuronal histopathological changes in the cortex and hypothalamus [6].
The olfactory pathway begins in bipolar cells located in the olfactory epithelium, from there its axons and dendrites extend to the olfactory bulb, where they make synapses with the cells present in this structure. Subsequently, this cranial pair is divided into two branches and is directed towards the olfactory nucleus present in the pyriform cortex [10] . This nerve route has been used by some coronaviruses in rodent models exposed to nasal inoculation [11,12].
Similar results were found in a Canadian study with another coronavirus, HCoV-OC43. In this case, by the fourth day of inoculation, the virus had already spread to the piriformis cortex, brain stem, and spinal cord [12].
The interesting thing about this possible propagation mechanism is the presence of the virus in areas of the brain stem [11,12], because this structure contains nuclei that regulate the respiratory rhythm. Breathing has central control given by the regulation of a number of neural groups. Through the nucleus of the solitary fascicle, the CNS receives information from the chemoreceptors that detect changes in the concentrations of CO2 and O2, alterations in these components lead to an increase or decrease in respiratory effort [13]. In this way, stem nuclei have connections with the respiratory system [1,13], and the entry of the coronavirus into this structure could trigger death by alteration of these neuronal groups [1].
In their analysis they found that 36.4% of the patients had neurological symptoms, these being directly related to the severity of the patient (severe cases VS non-severe: 40 [45.5%] vs. 38 [30.2%], P < .05). In patients with central symptoms (24.8%), 16.8% and 13.1% presented dizziness and headache, respectively. Among the peripheral symptoms (8.9%), the most common were hypogeusia and hyposmia with 5.6 and 5.1%.
"Zhou et al., detected the presence of the virus genome in the CSF [CerebroSpinal Fluid] of a 59-year-old patient with COVID-19 pneumonia, diagnosing viral encephalitis, demonstrating the direct damage that the virus produces in the CNS [Central Nervous System] [16]
The aforementioned makes us think that respiratory distress is not only the result of pulmonary inflammatory structural damage, but also due to the damage caused by the virus in the respiratory centers of the brain, making it more difficult to manage these patients."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141641/
PubMed Central (PMC)
Neurotropism of SARS-CoV 2: Mechanisms and manifestations
Disclaimer
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Last day tomorrow:
It's official - Train operators have announced plans to close nearly 1,000 ticket offices. We have until 1st September to take part in the public consultation. Can you take two minutes to respond to your train companyโs consultation and object to the closure of ticket offices? The RMT has prepared template letters for each train operator. ๐ Please have your say ๐https://www.rmt.org.uk/campaigns/rail/save-ticket-offices/
It's official - Train operators have announced plans to close nearly 1,000 ticket offices. We have until 1st September to take part in the public consultation. Can you take two minutes to respond to your train companyโs consultation and object to the closure of ticket offices? The RMT has prepared template letters for each train operator. ๐ Please have your say ๐https://www.rmt.org.uk/campaigns/rail/save-ticket-offices/
RMT
Save Ticket Offices
Over the last year the RMT has been campaigning against the DfT managed train companiesโ plans for wholesale ticket office closures. The result has been the largest ever response to a government consultation. On October 31, 2023 the government announced theโฆ
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๐ C19 INJECTIONS:
OVER 1 MILLION INJURIES
OVER 21,000 CASUALTIES
And that's with an under-reporting factor of 41X
"Mr. Johnson wrote: "Sadly, we passed two milestones on VAERS. Over 1 million advisers events and over 21,000 deaths, 30 percent of those deaths occurred on day 0, 1, or 2 following vaccination."
https://www.theepochtimes.com/article/sen-johnson-claims-cdc-abused-authority-engaged-in-censorship-campaign-of-covid-19-vaccine-posts-5483931
https://twitter.com/robinmonotti/status/1697237934897033557
OVER 1 MILLION INJURIES
OVER 21,000 CASUALTIES
And that's with an under-reporting factor of 41X
"Mr. Johnson wrote: "Sadly, we passed two milestones on VAERS. Over 1 million advisers events and over 21,000 deaths, 30 percent of those deaths occurred on day 0, 1, or 2 following vaccination."
https://www.theepochtimes.com/article/sen-johnson-claims-cdc-abused-authority-engaged-in-censorship-campaign-of-covid-19-vaccine-posts-5483931
https://twitter.com/robinmonotti/status/1697237934897033557
The Epoch Times
Sen. Johnson Claims CDC โAbused Authority,โ Engaged in โCensorship Campaignโ of COVID-19 Vaccine Posts
Wisconsin senator says CDC engaged in โcampaign to suppress and discredit certain viewpoints it labeled as โmisinformation.'โ
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COVID-19 VACCINATION IN CHILDREN (AND ADULTS) DECREASES IMMUNE RESPONSE TO OTHER PATHOGENS:
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1242380/full
"Our study showed that, in children, SARS-CoV-2 mRNA vaccination decreases inflammatory cytokine responses (IFN-ฮณ, MCP-1, IL-6, IL-8 and IL-15) to heterologous bacterial, fungal and viral re-stimulation. A pre-print of a study in 16 adult healthcare workers reported heterologous effects of the same mRNA-based vaccine used in our study (26). The study in adults found decreases in IFN-ฮณ and IL-6 production after stimulation with heterologous stimulants of bacterial and viral origin and increases in inflammatory cytokine production after C. albicans stimulation (26), in keeping with our findings.
Our findings suggest SARS-CoV-2 mRNA vaccination could alter the immune response to other pathogens, which cause both vaccine-preventable and non-vaccine-preventable diseases (34, 35). This is particularly relevant in children as they: have extensive exposure to microbes at daycare, school, and social occasions; are often encountering these microbes for the first time; and receive multiple vaccines as part of routine childhood vaccination schedules. There are currently no data on the clinical effects of COVID-19 vaccination-related heterologous effects in children."
These data show that a SARS-CoV-2 mRNA-based vaccine alters heterologous immunity in children and that these effects can persist up to six months after vaccination. Whether SARS-CoV-2 mRNA-based vaccines can induce the epigenetic and metabolic changes associated with trained immunity to provide protection against other infectious diseases remains an open question. That SARS-CoV-2 mRNA vaccination in children could impact immune responses to other pathogens emphasises the need for further research and consideration of heterologous effects in vaccination policies given their broad public health implications."
https://twitter.com/robinmonotti/status/1697244206711160953
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1242380/full
"Our study showed that, in children, SARS-CoV-2 mRNA vaccination decreases inflammatory cytokine responses (IFN-ฮณ, MCP-1, IL-6, IL-8 and IL-15) to heterologous bacterial, fungal and viral re-stimulation. A pre-print of a study in 16 adult healthcare workers reported heterologous effects of the same mRNA-based vaccine used in our study (26). The study in adults found decreases in IFN-ฮณ and IL-6 production after stimulation with heterologous stimulants of bacterial and viral origin and increases in inflammatory cytokine production after C. albicans stimulation (26), in keeping with our findings.
Our findings suggest SARS-CoV-2 mRNA vaccination could alter the immune response to other pathogens, which cause both vaccine-preventable and non-vaccine-preventable diseases (34, 35). This is particularly relevant in children as they: have extensive exposure to microbes at daycare, school, and social occasions; are often encountering these microbes for the first time; and receive multiple vaccines as part of routine childhood vaccination schedules. There are currently no data on the clinical effects of COVID-19 vaccination-related heterologous effects in children."
These data show that a SARS-CoV-2 mRNA-based vaccine alters heterologous immunity in children and that these effects can persist up to six months after vaccination. Whether SARS-CoV-2 mRNA-based vaccines can induce the epigenetic and metabolic changes associated with trained immunity to provide protection against other infectious diseases remains an open question. That SARS-CoV-2 mRNA vaccination in children could impact immune responses to other pathogens emphasises the need for further research and consideration of heterologous effects in vaccination policies given their broad public health implications."
https://twitter.com/robinmonotti/status/1697244206711160953
Frontiers
Frontiers | BNT162b2 COVID-19 vaccination in children alters cytokine responses to heterologous pathogens and Toll-like receptorโฆ
Background: Vaccines can have beneficial off-target (heterologous) effects that alter immune responses to, and protect against, unrelated infections. The het...
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Interesting take on cash, the more the merrier!
https://www.abc.net.au/news/2023-08-29/cash-stuffing-viral-saving-trend-cost-of-living-730/102599352
https://www.abc.net.au/news/2023-08-29/cash-stuffing-viral-saving-trend-cost-of-living-730/102599352
www.abc.net.au
Madison says she'll never use her card full-time again after discovering 'cash stuffing'
As cost-of-living pressures continue to climb, people are looking for creative ways to save. One method gaining popularity on social media is called "cash stuffing". It's a reinvention of the old envelope system our grandparents used to use, and it's bringingโฆ
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Anyone not yet clear about whatโs going to happen to their neighbourhood might want to check here.
Did you sign up to end private vehicle ownership? Or to go insectivorian?
Because youโre getting them anyway.
Mike
https://thefederalist.com/2023/08/19/these-14-american-cities-have-a-target-of-banning-meat-dairy-and-private-vehicles-by-2030/
Fourteen major American cities are part of a globalist climate organization known as the โC40 Cities Climate Leadership Group,โ which has an โambitious targetโ by the year 2030 of โ0 kg [of] meat consumption,โ โ0 kg [of] dairy consumption,โ โ3 new clothing items per person per year,โ โ0 private vehiclesโ owned, and โ1 short-haul return flight (less than 1500 km) every 3 years per person.โ
C40โs dystopian goals can be found in its โThe Future of Urban Consumption in a 1.5ยฐC Worldโ report, which was published in 2019 and reportedly reemphasized in 2023. The organization is headed and largely funded by Democrat billionaire Michael Bloomberg. Nearly 100 cities across the world make up the organization, and its American members include Austin, Boston, Chicago, Houston, Los Angeles, Miami, New Orleans, New York City, Philadelphia, Phoenix, Portland, San Francisco, Washington, D.C., and Seattle
Did you sign up to end private vehicle ownership? Or to go insectivorian?
Because youโre getting them anyway.
Mike
https://thefederalist.com/2023/08/19/these-14-american-cities-have-a-target-of-banning-meat-dairy-and-private-vehicles-by-2030/
Fourteen major American cities are part of a globalist climate organization known as the โC40 Cities Climate Leadership Group,โ which has an โambitious targetโ by the year 2030 of โ0 kg [of] meat consumption,โ โ0 kg [of] dairy consumption,โ โ3 new clothing items per person per year,โ โ0 private vehiclesโ owned, and โ1 short-haul return flight (less than 1500 km) every 3 years per person.โ
C40โs dystopian goals can be found in its โThe Future of Urban Consumption in a 1.5ยฐC Worldโ report, which was published in 2019 and reportedly reemphasized in 2023. The organization is headed and largely funded by Democrat billionaire Michael Bloomberg. Nearly 100 cities across the world make up the organization, and its American members include Austin, Boston, Chicago, Houston, Los Angeles, Miami, New Orleans, New York City, Philadelphia, Phoenix, Portland, San Francisco, Washington, D.C., and Seattle
The Federalist
These 14 US Cities Have A 'Target' Of Banning Meat By 2030
Fourteen major American cities are part of a globalist climate organization with an 'ambitious target' of banning meat and dairy by 2030.
๐คฌ101๐19โค14๐คฏ4๐1๐ค1๐1
http://www.whistleblowerreports.org/
Self explanatory. The site to read or listen to recordings made regularly by a small but international team!
Best wishes
Mike
Self explanatory. The site to read or listen to recordings made regularly by a small but international team!
Best wishes
Mike
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Just seen posted under a Substack article.
Dark but good.
Best wishes
Mike
Vaxxer, Vaxxer, so obsessed,
Wore your mask and took your tests.
Still got Covid, every strain,
Spike proteins inside your brain...
Short of breath at twenty four,
โDr. Fauci, give me more!"
Proteins tangle and misfold,
Myocarditis taking hold...
Swollen heart at twenty five,
"Thank Moderna I'm alive!"
But thereโs no cure for the micro-clot,
Getting worse with every shot...
Heart attack at twenty six,
Prayed to Pfizer for a fix.
Vaxxer, Vaxxer, death is lurking,
Doctor says, "That means it's working."...
Died of SADS at twenty seven,
All good Vaxxers go to heaven.
Obituary headline noted:
โAnti-Vaxxer Dies of Covid."...
His family is quite upset,
But they're alive, at least as yet.
And, they say, "Itโs for the better - Without the vax, he would be deader."
Dark but good.
Best wishes
Mike
Vaxxer, Vaxxer, so obsessed,
Wore your mask and took your tests.
Still got Covid, every strain,
Spike proteins inside your brain...
Short of breath at twenty four,
โDr. Fauci, give me more!"
Proteins tangle and misfold,
Myocarditis taking hold...
Swollen heart at twenty five,
"Thank Moderna I'm alive!"
But thereโs no cure for the micro-clot,
Getting worse with every shot...
Heart attack at twenty six,
Prayed to Pfizer for a fix.
Vaxxer, Vaxxer, death is lurking,
Doctor says, "That means it's working."...
Died of SADS at twenty seven,
All good Vaxxers go to heaven.
Obituary headline noted:
โAnti-Vaxxer Dies of Covid."...
His family is quite upset,
But they're alive, at least as yet.
And, they say, "Itโs for the better - Without the vax, he would be deader."
โก88๐69๐ฏ48โค37๐20๐ฅ17๐ข6๐1
Khan is definitely lying.
Why heโs lying is the better question.
Why heโs lying is the better question.
๐ฅ55๐15๐ค1
Forwarded from GovDotUK Watch
Freedom of Information (FOI):
Deaths in London as a result of car emissions
Release date: 26th April 2022
You asked
"How many deaths are recorded in London as a direct result of car emissions?
How many deaths are recorded in London as contributed by car emissions?"
There was 1 death registered in London in the period 2001 to 2021 which had exposure to air pollution recorded on the death certificate in either part 1 or part 2 of the death certificate. This death was attributed to environmental air pollution, however we are unable to determine whether this involved car emissions.
https://www.ons.gov.uk/aboutus/transparencyandgovernance/freedomofinformationfoi/deathsinlondonasaresultofcaremissions
Deaths in London as a result of car emissions
Release date: 26th April 2022
You asked
"How many deaths are recorded in London as a direct result of car emissions?
How many deaths are recorded in London as contributed by car emissions?"
There was 1 death registered in London in the period 2001 to 2021 which had exposure to air pollution recorded on the death certificate in either part 1 or part 2 of the death certificate. This death was attributed to environmental air pollution, however we are unable to determine whether this involved car emissions.
https://www.ons.gov.uk/aboutus/transparencyandgovernance/freedomofinformationfoi/deathsinlondonasaresultofcaremissions
๐ฅ48๐12โค2๐ข2
Please share this around everywhere you can. This is a live demonstration of digital Iโd tied to central bank digital currency tied to your vaxx is passport, et al. If we allow any one of those things to be required then the below is the result - total enslavement with no place to seek redress because courts say the subject is not justiciable and AI is running the world with dutiful, compliant Borg bureaucrats who do as they are told or NO FOOD FOR YOU! Arenโt we seeing the same thing in our government now? Dutiful Borg bureaucrats are already here requiring โvaccinesโ to work or go to school or the food store - as we have all witnessed and suffered? Imagine when they can legally starve you or euthanize you for failure to comply . . .
China. No digital ID no food. Facial recognition as digital ID required for getting SIM card, bank account, digital wallet, traveling by public transportation ... Once you are blacklisted by Social Credit Systerm, you will be flagged as enemy of the State - no food for you!!
Songpinganq on X
twitter.com
&
https://twitter.com/songpinganq/status/1628335223963521028
China. No digital ID no food. Facial recognition as digital ID required for getting SIM card, bank account, digital wallet, traveling by public transportation ... Once you are blacklisted by Social Credit Systerm, you will be flagged as enemy of the State - no food for you!!
Songpinganq on X
twitter.com
&
https://twitter.com/songpinganq/status/1628335223963521028
๐ฑ32๐คฌ25๐10โค4๐3๐ฅฐ1
Media is too big
VIEW IN TELEGRAM
Some people realised the high level themes early on. 14 years isnโt that long ago. However, I donโt think these ideas were new, then.
There is at least a 25y trail of tabletop simulations of infectious disease pandemics and of control of information.
Best wishes
Mike
There is at least a 25y trail of tabletop simulations of infectious disease pandemics and of control of information.
Best wishes
Mike
๐ฅ48๐ฏ23๐17โค8๐ค4๐ฑ3๐2๐2๐1
20 out of 40 vaccinated people were still producing vaccine derived spike protein 6 months after injection.
Vax Spike detected 6 months later in patients by Mass-Spec targeting the 2 Proline change.
Detectionof recombinant Spike protein in the blood of individuals vaccinated against SARSCoV2 - Carlo Brogna et al
https://onlinelibrary.wiley.com/doi/epdf/10.1002/prca.202300048
Vax Spike detected 6 months later in patients by Mass-Spec targeting the 2 Proline change.
Detectionof recombinant Spike protein in the blood of individuals vaccinated against SARSCoV2 - Carlo Brogna et al
https://onlinelibrary.wiley.com/doi/epdf/10.1002/prca.202300048
๐คฌ72๐10โค3๐ฅ2
Robin Monotti + Cory Morningstar
20 out of 40 vaccinated people were still producing vaccine derived spike protein 6 months after injection. Vax Spike detected 6 months later in patients by Mass-Spec targeting the 2 Proline change. Detectionof recombinant Spike protein in the blood of individualsโฆ
Carlo Brogna was also an author of the study which showed SARSCoV2 replicates in bacteria, indicating a possible transmission path.
https://t.me/robinmg/28083
https://t.me/robinmg/28083
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Forwarded from Andrija Klariฤ
Media is too big
VIEW IN TELEGRAM
TODAY at 22:20 on Z1 TV the guest is Mrs. Judith Curry, author of the book "Climate Uncertainties and Risk".
"There is no climate urgency. Climate change is misinterpreted. Man affects the climate in various ways, but the biggest driver of change comes from nature,"
You can follow the SHOW via livestream - www.z1tv.hr/hr/livestream
CHANNEL of the show "SLOBODNI" with all episodes - https://rumble.com/user/SLOBODNIpodcast
https://bit.ly/YouTubeSLOBODNIpodcast
Join http://t.me/andrijaklaric
Follow https://twitter.com/andrija_klaric
https://bit.ly/facebookandrijaklaric
https://instagram.com/andrijaklaric/
https://www.tiktok.com/@slobodni_podcast
https://www.winn.press/
"There is no climate urgency. Climate change is misinterpreted. Man affects the climate in various ways, but the biggest driver of change comes from nature,"
You can follow the SHOW via livestream - www.z1tv.hr/hr/livestream
CHANNEL of the show "SLOBODNI" with all episodes - https://rumble.com/user/SLOBODNIpodcast
https://bit.ly/YouTubeSLOBODNIpodcast
Join http://t.me/andrijaklaric
Follow https://twitter.com/andrija_klaric
https://bit.ly/facebookandrijaklaric
https://instagram.com/andrijaklaric/
https://www.tiktok.com/@slobodni_podcast
https://www.winn.press/
๐62๐10โค6
50% of respondents had neuropathological symptoms from early Covid19. It was NOT a normal flu: "Seasonal IV (Influenza Virus) infections only affect the human respiratory epithelium and the viruses never invade the central nervous system (CNS)."
https://link.springer.com/chapter/10.1007/978-3-319-33133-1_12?
Neurotropism of SARSCoV2:
https://t.me/robinmg/29924
https://link.springer.com/chapter/10.1007/978-3-319-33133-1_12?
Neurotropism of SARSCoV2:
https://t.me/robinmg/29924
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