"The spike-based vaccine conferred acute protection in the brain only if combined with the nucleocapsid-based vaccine.”
https://www.biorxiv.org/content/10.1101/2021.04.26.440920v1
https://www.biorxiv.org/content/10.1101/2021.04.26.440920v1
bioRxiv
A SARS CoV-2 nucleocapsid vaccine protects against distal viral dissemination
The SARS CoV-2 pandemic has killed millions of people. This viral infection can also result in substantial morbidity, including respiratory insufficiency and neurological manifestations, such as loss of smell and psychiatric diseases. Most SARS CoV-2 vaccines…
"We found that SARS survivors all have significant levels of antibodies remaining in their blood 17 years after infection. Anti-N antibodies waned more than anti-RBD antibodies, and the latter is known to play a more important role."
https://pubmed.ncbi.nlm.nih.gov/32529906/
https://pubmed.ncbi.nlm.nih.gov/32529906/
PubMed
Serological differentiation between COVID-19 and SARS infections - PubMed
In response to the coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, multiple diagnostic tests are required for acute disease diagnosis, contact tracing, monitoring asymptomatic infection rates and assessing herd immunity. While PCR remains…
Forwarded from Robin Monotti + Cory Morningstar
"SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity"
https://academic.oup.com/jmcb/article/12/12/916/6028992?s=09
https://academic.oup.com/jmcb/article/12/12/916/6028992?s=09
OUP Academic
SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity
Abstract. There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic syndrome, and metabolic syndrome predisposes patients to s
"Our laboratory only tested the effects of the SARS-CoV-2 spike protein in lung vascular cells and those implicated in the development of Pulmonary Arterial Hypertension. However, this protein may also affect the cells of systemic and coronary vasculatures, eliciting other cardiovascular diseases such as coronary artery disease, systemic hypertension, and stroke. In addition to cardiovascular cells, other cells that express ACE2 have the potential to be affected by the SARS-CoV-2 spike protein, which may cause adverse pathological events. Thus, it is important to consider the possibility that the SARS-CoV-2 spike protein produced by the new COVID-19 vaccines triggers cell signaling events that promote PAH, other cardiovascular complications, and/or complications in other tissues/organs in certain individuals"
Vaccines | Free Full-Text | SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines | HTML
https://www.mdpi.com/2076-393X/9/1/36/htm
Vaccines | Free Full-Text | SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines | HTML
https://www.mdpi.com/2076-393X/9/1/36/htm
MDPI
SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines
The world is suffering from the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses its spike protein to enter the host cells. Vaccines that introduce the spike protein into…
Forwarded from Robin Monotti + Cory Morningstar
"N protein is very similar between different coronaviruses – much more so than the spike protein. This means it’s possible that a protective immune response against SARS-CoV-2 N protein could also offer some protection against other related coronaviruses, such as Mers.
Another potential benefit that may arise from including N protein in SARS-CoV-2 vaccines is due to the low mutation rates seen in the N protein sequence. Some changes to the sequence of SARS-CoV-2 have been reported over the course of this pandemic, with the most significant changes occurring in the spike protein. There is some concern that if the spike sequence alters too much, then new vaccines will be required. This could be similar to the current need for annual updating of influenza vaccines. However, as the N protein sequence is much more stable than the spike, vaccines that include a component targeting the N protein are likely to be effective for longer."
https://theconversation.com/covid-vaccines-focus-on-the-spike-protein-but-heres-another-target-150315
Another potential benefit that may arise from including N protein in SARS-CoV-2 vaccines is due to the low mutation rates seen in the N protein sequence. Some changes to the sequence of SARS-CoV-2 have been reported over the course of this pandemic, with the most significant changes occurring in the spike protein. There is some concern that if the spike sequence alters too much, then new vaccines will be required. This could be similar to the current need for annual updating of influenza vaccines. However, as the N protein sequence is much more stable than the spike, vaccines that include a component targeting the N protein are likely to be effective for longer."
https://theconversation.com/covid-vaccines-focus-on-the-spike-protein-but-heres-another-target-150315
The Conversation
COVID vaccines focus on the spike protein – but here’s another target
New research shows why the N protein might be a good target.
Forwarded from Robin Monotti + Cory Morningstar
"The SARS-CoV-2 virus is more complicated than just a spike protein. There are, in fact, four different proteins that form the overall structure of the virus particle: spike, envelope (E), membrane (M) and nucleocapsid (N). In a natural infection, our immune system recognises all of these proteins to varying degrees. So how important are immune responses to these different proteins, and does it matter that the first vaccines will not replicate these?
Following SARS-CoV-2 infection, researchers have discovered that we actually make the most antibodies to the N protein – not the spike protein. This is the same for many different viruses that also have N proteins. But how N protein antibodies protect us from infection has been a long-standing mystery. This is because N protein is only found inside the virus particle, wrapped around the RNA. Therefore, N protein antibodies cannot block virus entry, will not be measured in neutralisation assays that test for this in the lab, and so have largely been overlooked."
Following SARS-CoV-2 infection, researchers have discovered that we actually make the most antibodies to the N protein – not the spike protein. This is the same for many different viruses that also have N proteins. But how N protein antibodies protect us from infection has been a long-standing mystery. This is because N protein is only found inside the virus particle, wrapped around the RNA. Therefore, N protein antibodies cannot block virus entry, will not be measured in neutralisation assays that test for this in the lab, and so have largely been overlooked."
2015: "To examine the emergence potential (the potential to infect humans) of circulating bat CoVs, we built a chimeric virus encoding a novel, zoonotic CoV spike protein -from the RsSHC014-CoV sequence that was isolated from Chinese horseshoe bats"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797993/#__ffn_sectitle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4797993/#__ffn_sectitle
PubMed Central (PMC)
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
Ralph Baric, Vineet Menachery and colleagues characterize a SARS-like coronavirus circulating in Chinese horseshoe bats to determine its potential to infect primary human airway epithelial cells, cause disease in mice and respond to available therapeutics.The…
2020: "India pulls up US CDC agency for doing unauthorized Nipah virus research"
https://theeasternlink.com/india-pulls-up-us-agency-for-doing-unauthorized-nipah-virus-research/
https://theeasternlink.com/india-pulls-up-us-agency-for-doing-unauthorized-nipah-virus-research/
The Eastern Link
India pulls up US agency for doing unauthorized Nipah virus research - The Eastern Link
The Indian government has pulled up the US government’s Center for Disease Control and Prevention (CDC) for funding an “unapproved” Indian laboratory in Manipal to do work on the deadly Nipah virus, and that too without permission. Nipah is considered a…
India: Whistleblower actor arrested for "vaccine misinformation". High court sets bail.
https://m.timesofindia.com/city/chennai/madras-high-court-orders-actor-mansoor-ali-khan-to-pay-rs-2-lakh-for-covid-19-vaccine-procurement/articleshow/82305786.cms
https://m.timesofindia.com/city/chennai/madras-high-court-orders-actor-mansoor-ali-khan-to-pay-rs-2-lakh-for-covid-19-vaccine-procurement/articleshow/82305786.cms
The Times of India
Mansoor Ali Khan: Madras high court orders actor Mansoor Ali Khan to pay Rs 2 lakh for Covishield procurement | Chennai News …
The issue pertains to statements made by Mansoor Ali Khan before a private hospital where actor Vivek was admitted after he suffered a heart attack on
Forwarded from GreatGameInternational
THIS IS BIG
Officers from the specialized verticals of the Epidemic Intelligence Service (EIS), a programme of the US CDC will reach India soon.
The main objective of these EIS officers also referred to as Disease Detectives is to carry out COVID-19 surveillance in India and advice the government on future action.
The EIS arose from biological warfare concerns relating to the Korean War.
What is of concern is that the CDC was banned by the Indian government in late 2019 for secretly funding bioweapons research in India.
Read more 👉🏽 https://greatgameindia.com/cdc-intelligence-officers-india/
Officers from the specialized verticals of the Epidemic Intelligence Service (EIS), a programme of the US CDC will reach India soon.
The main objective of these EIS officers also referred to as Disease Detectives is to carry out COVID-19 surveillance in India and advice the government on future action.
The EIS arose from biological warfare concerns relating to the Korean War.
What is of concern is that the CDC was banned by the Indian government in late 2019 for secretly funding bioweapons research in India.
Read more 👉🏽 https://greatgameindia.com/cdc-intelligence-officers-india/
GreatGameIndia
American CDC's Epidemic Intelligence Officers To Be Deployed In India For COVID-19 Surveillance - GreatGameIndia
Officers from the specialized verticals of the Epidemic Intelligence Service (EIS), a programme of the US CDC will reach India soon. The main objective of these EIS officers also referred to as Disease Detectives is to carry out COVID-19 surveillance in India…
Forwarded from Adverse Reactions Following Immunization-INDIA (AEFI-INDIA)
706 teachers on election duty died due to COVID-19 in Uttar Pradesh Panchayat Elections. (April 30, 2021)
https://www.livehindustan.com/uttar-pradesh/story-politics-heats-up-over-700-teachers-killed-in-up-panchayat-elections-teachers-unions-demand-postponement-of-counting-4003857.html
Unfortunately, COVID-19 vaccination was made mandatory for everyone on election duty by Election Commission of India. (February 27, 2021)
Everyone On Election Duty To Get COVID-19 Vaccine Before Voting Day: Poll Panel
https://www.ndtv.com/india-news/everyone-on-election-duty-to-get-covid-19-vaccine-before-voting-day-election-commission-2379724
Everyone on poll duty to get Covid-19 vaccine before assembly elections: EC
https://www.business-standard.com/article/elections/everyone-on-poll-duty-to-get-covid-19-vaccine-before-assembly-elections-ec-121022600837_1.html
No one will point out the obvious link between the vaccination and deaths of so many teachers within just one month. Everything will be swept under the carpet.
And more alarming thing is that, theses deaths are from Uttar Pradesh state alone. 5 other States had/are gone/going through assembly elections namely Assam, West Bengal, Tamilnadu, Puducherry and Kerala.
There's no data on deaths occurred between election duty personel in these states.
https://www.livehindustan.com/uttar-pradesh/story-politics-heats-up-over-700-teachers-killed-in-up-panchayat-elections-teachers-unions-demand-postponement-of-counting-4003857.html
Unfortunately, COVID-19 vaccination was made mandatory for everyone on election duty by Election Commission of India. (February 27, 2021)
Everyone On Election Duty To Get COVID-19 Vaccine Before Voting Day: Poll Panel
https://www.ndtv.com/india-news/everyone-on-election-duty-to-get-covid-19-vaccine-before-voting-day-election-commission-2379724
Everyone on poll duty to get Covid-19 vaccine before assembly elections: EC
https://www.business-standard.com/article/elections/everyone-on-poll-duty-to-get-covid-19-vaccine-before-assembly-elections-ec-121022600837_1.html
No one will point out the obvious link between the vaccination and deaths of so many teachers within just one month. Everything will be swept under the carpet.
And more alarming thing is that, theses deaths are from Uttar Pradesh state alone. 5 other States had/are gone/going through assembly elections namely Assam, West Bengal, Tamilnadu, Puducherry and Kerala.
There's no data on deaths occurred between election duty personel in these states.
Hindustan
UP पंचायत चुनाव में लगे 700 से ज्यादा टीचरों की मौत पर गरमाई सियासत, शिक्षक संघों ने की मतगणना स्थगित करने की मांग
पंचायत चुनाव में लगे लगभग 706 शिक्षकों की मौत को लेकर गुरुवार को सियासत गर्मा गई। प्रमुख विपक्षी दल शिक्षकों की लड़ाई में उनके साथ उतर आए हैं। कांग्रेस महासचिव प्रियंका गांधी और सपा मुखिया व पूर्व...
"My relevant experience is as a district education director responsible for integration of immunocompromised, profoundly disabled, undocumented, Autistic, and behaviorally challenged students under full ADA, IDEA, and OSHA compliance, with a background in hazardous environs 2/
PPE applications, which includes which respirators work when and why.
My experience grants me the capacity, for instance, to understand specifically how none of you sitting before us today are protected against Covid size particulates, nor are you protecting others - but you 3/
know this already, don’t you?
It is critical information to consider that there are ZERO efficacy standards for child size masks. You are requiring untested, unregulated apparatuses which restrict breathing, cause increased carbon dioxide, and are a petri dish of secondary 4/
pathogen directly in front of oral/nasal mucosa.
You tell me if you think this sounds like something that would pass an ethics review board. We're going to take a bunch of kids and put them in this apparatus, ok? They'll be in it for 8 hours per day, up to 12 if they are 5/
in extended day programs. We will not ask for medical clearance or medical consent, but this apparatus will cause deoxygenation and hypercapnia, and children being the sanitary creatures that they are, will drop them, wear them into restrooms where they pick up fecal matter 6/
and other pathogen from toilet plumes. I hope each of you who have worn a mask in a public restroom today recoil in horror at the realization of what you’re breathing - tasting, even - all day long. Kids wear them all day. To be exempt, they must fight tooth and nail and face 7/
rampant rejection. Would this pass an ethics review in your opinion? Of course it wouldn't, but here we are, and this is what you are doing to children in this school system every day, even our truly immunocompromised, in unregulated, unsafe garbage which exacerbates the 8/
spread of airborne pathogen. But we're all in this together, right?
Cloth and surgical masks are expressly non-mitigating for airborne pathogen. Covid has a minimum particle size of .06 microns, which if part of a larger cluster still easily falls within the radically behaving 9
particulate range. Add in plosive force, which is the varying outward respiratory pressure, and you have much like water through a garden hose on the mister setting - droplet into aerosol - where the tighter the fit, the greater the pressure of fine particulates in an outward 10/
plume, effectively taking what falls in a predictable 6 foot arc and sending it an 18-20 foot trajectory, remaining aloft for hours in enclosed spaces. 90% of exhaled emitted particulates fall within the radically behaving particulate range - what you have is truly an airborne pathogen. "
https://threadreaderapp.com/thread/1387378962406461440.html?s=09
PPE applications, which includes which respirators work when and why.
My experience grants me the capacity, for instance, to understand specifically how none of you sitting before us today are protected against Covid size particulates, nor are you protecting others - but you 3/
know this already, don’t you?
It is critical information to consider that there are ZERO efficacy standards for child size masks. You are requiring untested, unregulated apparatuses which restrict breathing, cause increased carbon dioxide, and are a petri dish of secondary 4/
pathogen directly in front of oral/nasal mucosa.
You tell me if you think this sounds like something that would pass an ethics review board. We're going to take a bunch of kids and put them in this apparatus, ok? They'll be in it for 8 hours per day, up to 12 if they are 5/
in extended day programs. We will not ask for medical clearance or medical consent, but this apparatus will cause deoxygenation and hypercapnia, and children being the sanitary creatures that they are, will drop them, wear them into restrooms where they pick up fecal matter 6/
and other pathogen from toilet plumes. I hope each of you who have worn a mask in a public restroom today recoil in horror at the realization of what you’re breathing - tasting, even - all day long. Kids wear them all day. To be exempt, they must fight tooth and nail and face 7/
rampant rejection. Would this pass an ethics review in your opinion? Of course it wouldn't, but here we are, and this is what you are doing to children in this school system every day, even our truly immunocompromised, in unregulated, unsafe garbage which exacerbates the 8/
spread of airborne pathogen. But we're all in this together, right?
Cloth and surgical masks are expressly non-mitigating for airborne pathogen. Covid has a minimum particle size of .06 microns, which if part of a larger cluster still easily falls within the radically behaving 9
particulate range. Add in plosive force, which is the varying outward respiratory pressure, and you have much like water through a garden hose on the mister setting - droplet into aerosol - where the tighter the fit, the greater the pressure of fine particulates in an outward 10/
plume, effectively taking what falls in a predictable 6 foot arc and sending it an 18-20 foot trajectory, remaining aloft for hours in enclosed spaces. 90% of exhaled emitted particulates fall within the radically behaving particulate range - what you have is truly an airborne pathogen. "
https://threadreaderapp.com/thread/1387378962406461440.html?s=09
Threadreaderapp
Thread by @mamasaurusMeg on Thread Reader App
Thread by @mamasaurusMeg: Here is what I said, other than just,🤢 “I hope each of you who have worn a mask in a public restroom today recoil in horror at the realization of what you’re breathing...
👏1
Forwarded from Deleted Account
Here is another nice one. Sample of uninfected people in Singapore showed 50% had T cell immunity.
"Our team also tested uninfected healthy individuals and found SARS-CoV-2-specific T cells in more than 50 percent of them. This could be due to cross-reactive immunity obtained from exposure to other coronaviruses, such as those causing the common cold, or presently unknown animal coronaviruses. "
https://www.sciencedaily.com/releases/2020/07/200716101536.htm
"Our team also tested uninfected healthy individuals and found SARS-CoV-2-specific T cells in more than 50 percent of them. This could be due to cross-reactive immunity obtained from exposure to other coronaviruses, such as those causing the common cold, or presently unknown animal coronaviruses. "
https://www.sciencedaily.com/releases/2020/07/200716101536.htm
ScienceDaily
Scientists uncover SARS-CoV-2-specific T cell immunity in recovered COVID-19 and SARS patients
The T cells, along with antibodies, are an integral part of the human immune response against viral infections due to their ability to directly target and kill infected cells. A Singapore study has uncovered the presence of virus-specific T cell immunity…
Forwarded from Mike Yeadon
I agree entirely. I asked around my network & thought in relation to my own situation. The consistent barrier is censorship. We are used, through history, to seeing sometimes very small numbers of determined individuals making a difference. But when one’s ideas, conclusions, analysis & even human outrage is subject to the whims of the state, we have a problem of an entirely different dimension.
As a former commercial scientist, I have absolutely no idea about public campaigning.
I’ve deliberately offered my insights in the hope that someone or a group with campaigning skills would be provided with the evidence that they required in order to persuade others of the deception(s).
I’ve been disappointed that literally no one has approached me in that spirit, not once.
Some appear to assume I’d be doing that, too. I’m hopelessly unsuited to such a role (essentially politics). I’m neither physically robust enough to do something like this & I’m constitutionally a poor fit to anything like that. I find it tough to hold my tongue.
So a leader who can & wants to lead is minimally required, in my opinion.
Anyone who comes aboard, or has today’s equivalent of their own Man-O-War, will find a willing crew to cover all the staffing needs of an aggressive campaigning group.
I’ve thought about this. Imagine you’re running a multi day table top simulation. The leadership operating what I’m sure they considered an outlandish scenario would have had much thinking time to answer this question:
“What measures & responses should be expected from the public at large? How can we ensure that these are neutralised such that none of these succeed?”
I came to to not very surprising, but nevertheless useful, conclusion that pretty much ANYTHING we have done or plan to do, if it really fits in the “obvious & expected” category of responses, my working assumption is that the crooks have already neutralised it.
Perhaps the most likely breakthrough would come from moving down a path which is not predicted? A course of action that they are most unlikely to have anticipated?
Not that I know what & how. Just bringing a non-politicians eye view to the scene.
I’m open to trying almost anything. Despite my best efforts & in spite of the kind & uplifting words if many, the harsh reality is I’ve not altered the trajectory or timing of anything at all.
Best wishes
Mike
As a former commercial scientist, I have absolutely no idea about public campaigning.
I’ve deliberately offered my insights in the hope that someone or a group with campaigning skills would be provided with the evidence that they required in order to persuade others of the deception(s).
I’ve been disappointed that literally no one has approached me in that spirit, not once.
Some appear to assume I’d be doing that, too. I’m hopelessly unsuited to such a role (essentially politics). I’m neither physically robust enough to do something like this & I’m constitutionally a poor fit to anything like that. I find it tough to hold my tongue.
So a leader who can & wants to lead is minimally required, in my opinion.
Anyone who comes aboard, or has today’s equivalent of their own Man-O-War, will find a willing crew to cover all the staffing needs of an aggressive campaigning group.
I’ve thought about this. Imagine you’re running a multi day table top simulation. The leadership operating what I’m sure they considered an outlandish scenario would have had much thinking time to answer this question:
“What measures & responses should be expected from the public at large? How can we ensure that these are neutralised such that none of these succeed?”
I came to to not very surprising, but nevertheless useful, conclusion that pretty much ANYTHING we have done or plan to do, if it really fits in the “obvious & expected” category of responses, my working assumption is that the crooks have already neutralised it.
Perhaps the most likely breakthrough would come from moving down a path which is not predicted? A course of action that they are most unlikely to have anticipated?
Not that I know what & how. Just bringing a non-politicians eye view to the scene.
I’m open to trying almost anything. Despite my best efforts & in spite of the kind & uplifting words if many, the harsh reality is I’ve not altered the trajectory or timing of anything at all.
Best wishes
Mike
Forwarded from Mike Yeadon
Robin,
I agree that natural immunity and even that from the vaccines (assuming they work as claimed) will easily cope with variants.
A key point GVB has repeatedly failed to answer for is this: in the event that a variant had ‘rolled the dice’ so luckily that it evaded my immune system, it will not have evaded yours. Most people don’t know that we each create immunity using a unique combination of recognition points about the pathogen. That’s called our immune repertoire. If a variant bypasses my repertoire, yours, being different, will continue to detect variants & defend you against them.
In other words, immune escape is a phenomenon that initially only impacts individuals & not communities.
Cheers,
Mike
I agree that natural immunity and even that from the vaccines (assuming they work as claimed) will easily cope with variants.
A key point GVB has repeatedly failed to answer for is this: in the event that a variant had ‘rolled the dice’ so luckily that it evaded my immune system, it will not have evaded yours. Most people don’t know that we each create immunity using a unique combination of recognition points about the pathogen. That’s called our immune repertoire. If a variant bypasses my repertoire, yours, being different, will continue to detect variants & defend you against them.
In other words, immune escape is a phenomenon that initially only impacts individuals & not communities.
Cheers,
Mike
Forwarded from Ad
The only way to beat a corrupt machine with tentacles stretching everywhere is with a constantly growing grassroots movement.
The rally in London shows your message, and others, is getting through. I remember your column in the Mail last year, the comments were overwhelmingly positive - good examples that folk do respond to the message, it's just not usually allowed a platform.
Would be willing to wager you / Gupta / Heneghan (etc) wouldn't be that far off the govt scientists in a public vote of 'Covid confidence', despite them having all the propaganda machinations behind them.
The rally in London shows your message, and others, is getting through. I remember your column in the Mail last year, the comments were overwhelmingly positive - good examples that folk do respond to the message, it's just not usually allowed a platform.
Would be willing to wager you / Gupta / Heneghan (etc) wouldn't be that far off the govt scientists in a public vote of 'Covid confidence', despite them having all the propaganda machinations behind them.
The spike protein has gone to meet its maker..or has it?
https://www.youtube.com/watch?v=XeIrGrIv7eE
https://www.youtube.com/watch?v=XeIrGrIv7eE
YouTube
Ralph Baric receives SARS-CoV-2 vaccine
Ralph Baric, PhD, William R. Kenan, Jr. Distinguished Professor in the Department of Epidemiology, receives the SARS-CoV-2 vaccine manufactured by Moderna, Inc.
INDIA EXPLAINED IN TWO IMAGES. THE MUTANT IS THE ASTRAZENECA "COVISHIELD" ADENOVIRUS VECTOR + SPIKE
Yogurt. Not jabs.
https://greatgameindia.com/yogurt-cytokine-storm-covid-19/
https://greatgameindia.com/yogurt-cytokine-storm-covid-19/
GreatGameIndia
Groundbreaking Study Finds Yogurt Can Mitigate Cytokine Storms In COVID-19 Patients By Disrupting Cell Communications - GreatGameIndia
A groundbreaking study by Israeli scientists have found that yogurt can mitigate cytokine storms in COVID-19 patients by disrupting communication between cells.