๋ฌป๋”ฐ๋ฐฉ ๐Ÿ•
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(๋ฐฉ์žฅํ•œํ…Œ) ๋ฌป์ง€๋„ ๋”ฐ์ง€์ง€๋„ ์•Š๋Š” ๋ฐฉ

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https://litt.ly/mootda

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Forwarded from Nittany ATOM Land
๋•Œ๋งˆ์นจ FLR ์ง€๋ถ„ ๋ณ€๋™๊ณต์‹œ ๋‚˜์˜ด. ๊ธฐ์กด 7.5%์—์„œ 3.9%๋กœ ๊ฐ์†Œ. ์ดํ‹€๋™์•ˆ ์•ฝ 1,300๋งŒ์ฃผ ๋งค๋„. ๋‚จ์€ ๋ฌผ๋Ÿ‰๋„ ์ผ์ฃผ์ผ ์ด๋‚ด ์ฒ˜๋ถ„ ๊ฐ€๋Šฅ.

https://d18rn0p25nwr6d.cloudfront.net/CIK-0001124198/a42ba459-bb61-414d-9117-3fa660a38ed3.pdf
๐Ÿ‘2
๊ณ„์ขŒ์— SMR, SMU ์ฃผ๊ฐ€๋ฅผ ๋ณด๋Š” ๋‚ด ์‹ฌ์ •
๐Ÿซก169๐Ÿคฃ74
[์•Œ์ง€๋…ธ๋ฏน์Šค/๋กœ์Šˆ ๊ณต๋™๊ฐœ๋ฐœ RZ-001 ์ž„์ƒ 1/2a์ƒ AACR ๊ตฌ๋‘๋ฐœํ‘œ ์ดˆ๋ก ๊ณต๊ฐœ]

4์›” 19์ผ์—๋Š” ์ดˆ๋ก ์ œ์ถœ ๋‹น์‹œ๋ณด๋‹ค ๋”์šฑ ์ง„ํ–‰๋œ ์ž„์ƒ ๊ฒฐ๊ณผ๊นŒ์ง€ ์—…๋ฐ์ดํŠธ๋˜์–ด ๊ตฌ๋‘ ๋ฐœํ‘œ๋  ์˜ˆ์ •

[์œ ํšจ์„ฑ]
RZ-001 ๋ณ‘์šฉ์š”๋ฒ• mRECIST ๊ธฐ์ค€ ORR 53.8%(7/13), ์™„์ „๊ด€ํ•ด CR 23%(3/13)

vs. ๋กœ์Šˆ ์•„๋ฐ”์Šคํ‹ด/ํ‹ฐ์ŽˆํŠธ๋ฆญ mRECIST ORR 35%, CR 12% (IMbrave150 ์ž„์ƒ 3์ƒ)

(ํ™˜์ž ์™„์ „๊ด€ํ•ด(CR) ์ผ€์ด์Šค)
- 2๋ช… 6์ฃผ์ฐจ์— CR, 1๋ช… 30์ฃผ์ฐจ๊นŒ์ง€ CR ์œ ์ง€, 1๋ช…์€ ๋‹จ๋ฐฑ๋‡จ๋กœ ์ธํ•œ ์ค‘๋‹จ ์ „์ธ 18์ฃผ๊นŒ์ง€ CR ์œ ์ง€, 1๋ช… 24์ฃผ์ฐจ PR์—์„œ ์ „ํ™˜๋œ CR ๋‹ฌ์„ฑ

- 12์ฃผ ์ด์ƒ ์น˜๋ฃŒ๊ตฐ์—์„œ ORR 75%(6/8)
- ํ‘œ์ค€์น˜๋ฃŒ ORR 30% ๋Œ€๋น„ ๊ฐœ์„ ํญ 10%p ์ด์ƒ
- ์งˆ๋ณ‘ ํ†ต์ œ์œจ(CR+PR+SD) 92% (12/13)

[์•ˆ์ „์„ฑ]
- DLT(์šฉ๋Ÿ‰์ œํ•œ๋…์„ฑ) ์‹ฌ๊ฐํ•œ ๋ถ€์ž‘์šฉ ๋ฏธ๊ด€์ฐฐ
- 4~5๋“ฑ๊ธ‰ ์ด์ƒ๋ฐ˜์‘/3๋“ฑ๊ธ‰ ์ด์ƒ ๋ฉด์—ญ ๊ด€๋ จ ์ด์ƒ๋ฐ˜์‘ ๋ฏธ๋ณด๊ณ 

https://aacrjournals.org/cancerres/article/86/8_Supplement/CT030/783107/Abstract-CT030-A-phase-1b-2a-open-label?searchresult=1

https://rznomics.com/bbs/?so_table=promote_en
๐Ÿ‘8โค2๐Ÿ–•1
[๋ณด๋กœ๋…ธ์ด VRN11 ์ž„์ƒ 1a์ƒ AACR ํฌ์Šคํ„ฐ ๋ฐœํ‘œ ์ดˆ๋ก ๊ณต๊ฐœ]

๋น„์†Œ์„ธํฌํ์•” mEGFR C797S ํ™˜์ž ๋Œ€์ƒ ์ž„์ƒ 1a์ƒ ์ค‘๊ฐ„์šฉ๋Ÿ‰ ํˆฌ์—ฌ ๊ฒฐ๊ณผ ๋ถ€์ž‘์šฉ ๋ฏธ๊ด€์ฐฐ ๋ฐ ์ฆ๋Ÿ‰๋œ ์ƒˆ๋กœ์šด ์šฉ๋Ÿ‰์—์„œ C797S 3๋ช… ๋ชจ๋‘ PR

๊ธฐ์กด 240mg ๋ฐ์ดํ„ฐ ORR 75%(3/4๋ช…), ๋‡Œ์ „์ด ์™„์ „๊ด€ํ•ด 50%(2/4๋ช…)๋ณด๋‹ค ๋†’์•„์ง„ ORR 85.7%(6/7๋ช…), ๊ณ ์šฉ๋Ÿ‰์œผ๋กœ ๋†’์•„์งˆ์ˆ˜๋ก all PR ์ค‘

[์œ ํšจ์„ฑ]
- ๊ฐ๊ด€์  ๋ฐ˜์‘๋ฅ (ORR) 85.7%(6/7๋ช…)
- C797S ํฌํ•จํ•œ EGFR ๋ณ€์ด๋ฅผ ๊ฐ€์ง„ 7๋ช…์ค‘ 6๋ช… ๋ถ€๋ถ„ ๋ฐ˜์‘(PR)์„ ๋‹ฌ์„ฑ
- ๋ถ„์ž ๋ฐ˜์‘ ํ‰๊ฐ€ ๊ฐ€๋Šฅํ•œ 5๋ช… ๋ชจ๋‘ ctDNA ๊ฐ์†Œ ๋ฐ 4๋ช… ctDNA ์™„์ „ ์ œ๊ฑฐ

[์•ˆ์ „์„ฑ]
- 480mg๊นŒ์ง€ DLT ์šฉ๋Ÿ‰์ œํ•œ๋…์„ฑ ๋ฏธ๊ด€์ฐฐ
- ํƒ€๊ทธ๋ฆฌ์†Œ(์˜ค์‹œ๋จธํ‹ฐ๋‹™) ์•ˆ์ „์„ฑ ํ”„๋กœํŒŒ์ผ์— ๋น„๊ตํ•ด ์›”๋“ฑํžˆ ์œ ๋ฆฌํ•œ ์•ˆ์ „์„ฑ ํ”„๋กœํŒŒ์ผ
- PK ๋ถ„์„ ๊ฒฐ๊ณผ, 160mg๋ถ€ํ„ฐ EGFR ๋ณ€์ด์— ๋Œ€ํ•ด ํ˜ˆ์žฅ ๋†๋„๊ฐ€ IC90์„ ์ดˆ๊ณผํ•˜๋Š” ์šฉ๋Ÿ‰ ๋น„๋ก€ ์ „์‹  ๋…ธ์ถœ (160mg ์šฉ๋Ÿ‰๋ถ€ํ„ฐ ํ™˜์ž์˜ ํ˜ˆ์•ก ์† C797S ๋ฅผ 90% ์ด์ƒ ์–ต์ œํ•˜๋Š” ๋ฐ ํ•„์š”ํ•œ ๋†๋„(IC90)๋ฅผ ๋„˜๊ณ  ์žˆ๋‹ค๋Š” ์˜๋ฏธ)

https://aacrjournals.org/cancerres/article/86/8_Supplement/LB336/782960/Abstract-LB336-VRN110755-A-next-generation-non?searchresult=1
๐Ÿ‘5โค2๐Ÿ–•1
์•Œ์ง€, ๋ณด๋กœ ๋‘˜๋‹ค ์ข‹์€๋ฐ ๋ญ๊ฐ€ ๋” ์ข‹์€์ง€ ํŒ๋‹จ์€ ๊ฐœ์ทจ์ธ๋“ฏ

์ƒˆ๋กœ์šด ํ”Œ๋žซํผ ํƒ„์ƒ - ์•Œ์ง€๋…ธ๋ฏน์Šค
๊ธ€๋กœ๋ฒŒ ๋น…๋”œ ๊ฐ€๋Šฅ์„ฑ - ๋ณด๋กœ๋…ธ์ด
โค15๐Ÿ–•7
RZ001 RECIST๋ƒ mRECIST๋ƒ ๋ง์ด ์žˆ๋Š”๋ฐ ์• ์ดˆ์— mRECIST๊ฐ€ HCC์—์„œ RECIST ์ธก์ •์ด ์ž‘๋™์„ ์•ˆ ํ•˜๋Š” ์ผ€์ด์Šค ๋•Œ๋ฌธ์— AASLD์—์„œ ๊ฐ€์ด๋“œ๋ผ์ธ์„ ๋ฐœํ‘œํ•œ ๊ฑฐ๋ผ... mRECIST๋กœ ๋ณด๋Š” ๊ฒŒ ๋งž์Šต๋‹ˆ๋‹ค

FDA๋‚˜ EMA๋Š” Regulatory ๊ธฐ๊ด€์ด๊ธฐ์— ๊ฐ„์—์„œ๋งŒ ๋”ฐ๋กœ mRECIST๋ฅผ ๋—ด์–ด์„œ ๋ณด์ง„ ์•Š์Šต๋‹ˆ๋‹ค. ์ด๊ฑด ์–ด๋–ค ๊ณ ํ˜•์•”์—์„œ๋„ ๋งˆ์ฐฌ๊ฐ€์ง€๊ตฌ์š”.

hepatology์—์„œ ์–‘๋Œ€ ์‚ฐ๋งฅ์ธ AASLD๋ž‘ EASL ๋ชจ๋‘ mRECIST๋ฅผ ํ‘œ์ค€์œผ๋กœ ์‚ผ๊ณ  ์žˆ๊ณ , mRECIST ์—†์ด๋Š” ๋ฐ์ดํ„ฐ ๋…ผ์˜ ์ž์ฒด๊ฐ€ ๋ฌด์˜๋ฏธํ•˜๋‹ค๊ณ  ๋ณด์‹ฌ ๋ฉ๋‹ˆ๋‹ค
๐Ÿ–•4๐Ÿ‘3
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์ „๋ฐฉ์— ํ•จ์„ฑ ๋ฐœ์‚ฌ!!!
๐Ÿ‘4๐Ÿ–•3
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โ–  ์†๋„๋Š” ๋‚ฎ์ง€๋งŒ ์ƒ์„ ์˜ ์ •์ƒ ํ†ต๊ณผ๊ฐ€ ์ง„ํ–‰๋˜๊ณ  ์žˆ๋Š” ๊ฒƒ์œผ๋กœ ๋ณด์ž…๋‹ˆ๋‹ค.

#ํ˜ธ๋ฅด๋ฌด์ฆˆ
โšก9๐Ÿ–•5โค1๐Ÿ‘1
#์‚ผ์„ฑ์ด์•ค์—์ด (์‚ผ์„ฑE&A) #์‚ผ์„ฑ์ „์ž

์‚ผ์„ฑ์ „์ž ํ‰ํƒ์บ ํผ์Šค P5 ๊ณต์‚ฌ ๊ณ„์•ฝ๊ธˆ์•ก 3.41๋ฐฐ ์ฆ๊ฐ€

5500์–ต โž” 1์กฐ 8790์–ต
โค8
์œ ์กฐ์„ ์— ์ด๋ ‡๊ฒŒ ํ•˜๋ฉ”๋„ค์ด ์ดˆ์ƒํ™”๋กœ ๋„๋ฐฐํ•ด๋†“์œผ๋ฉด ์ด๋ž€๋„ ๋ชป๊ฑด๋“ค๊ฑฐ ๊ฐ™์€๋ฐ
โค104๐Ÿ˜2
์œ ๋Ÿฝ ๋™๋งน์˜ ํ˜ธ๋ฅด๋ฌด์ฆˆ ๋ถ„์Ÿ ๋น„ํ˜‘์กฐ๊ฐ€ ๋ฏธ๊ตญ์‚ฐ ์ง€์ƒ ๋ฌด๊ธฐ์˜ ์œ ๋Ÿฝํ–ฅ ๋‚ฉ๊ธฐ ์ง€์—ฐ์œผ๋กœ ์ด์–ด์ง€๋Š” ์ค‘

ํœด์ „ ํ˜น์€ ํ™•์ „๊ณผ ๋ณ„๊ฐœ๋กœ ์žฌ๋ฌด์žฅ + ๋‹ค๋ณ€ํ™” ์ˆ˜์š” ํ™•๋Œ€ ๋”ฐ๋ฅธ K๋ฐฉ์‚ฐ ์ˆ˜ํ˜œ

The delayed weaponry includes various kinds of ammunition, including munitions that can be used for both offensive and defensive purposes, the sources said.

U.S. officials say the weapons are needed for the war in the Middle East, and they fault European nations for not helping the U.S. and Israel open the Strait of Hormuz

https://www.militarytimes.com/news/pentagon-congress/2026/04/17/us-to-delay-weapons-deliveries-to-some-european-countries-due-to-iran-war-sources-say/
โค6๐Ÿ‘3๐Ÿ‘Ž1
๋ชจ๋‘ ๊ฑด๊ฐ•์ด ์ตœ๊ณฑ๋‹ˆ๋‹ค
๊ฑด๊ฐ•ํ•˜์„ธ์š”
๐Ÿ˜ข8๐Ÿ”ฅ4โค1
โ”” Gas Gas Gas
๐Ÿ”ฅ6