Is aircraft #noise exposure associated with #cardiovascular disease and hypertension? Results from a cohort study in Athens, Greece
http://oem.bmj.com/content/early/2017/05/08/oemed-2016-104180

Background We followed up, in 2013, the subjects who lived near the Athens International Airport and had participated in the cross-sectional multicountry HYENA study in 2004–2006. Results The incidence of hypertension was significantly associated with higher aircraft noise exposure during the night. Specifically, the OR for hypertension per 10 dB increase in Lnight aircraft noise exposure was 2.63 (95% CI 1.21 to 5.71). Doctor-diagnosed cardiac arrhythmia was significantly associated with Lnight aircraft noise exposure, when prevalent and incident cases were considered with an OR of 2.09 (95% CI 1.07 to 4.08). Stroke risk was also increased with increasing noise exposure but the association was not significant. Twenty-four-hour road traffic noise associations with the outcomes considered were weaker and less consistent.

Conclusions In conclusion, our cohort study suggests that long-term exposure to aircraft noise, particularly during the night, is associated with incident hypertension and possibly, also, cardiovascular effects.

Safety and efficacy of #ebselen for the prevention of #noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(17)31791-9/abstract

Mean TTS at 4 kHz was 1·32 dB (SE 0·91) in the 400 mg ebselen group compared with 4·07 dB (0·90) in the placebo group, representing a significant reduction of 68% (difference −2·75 dB, 95% CI −4·54 to −0·97; p=0·0025). Compared with placebo, TTS at 4 kHz was non-significantly reduced by 21% in the 200 mg ebselen group (3·23 dB [SE 0·91] vs 4·07 dB [0·90] in the placebo group; difference −0·84 dB, 95% CI −2·63 to 0·94; p=0·3542) and by 7% in the 600 mg ebselen group (3·81 dB [0·90] vs 4·07 dB [0·90] in the placebo group; difference −0·27, 95% CI −2·03 to 1·50; p=0·7659). Ebselen treatment was well tolerated across all doses and no significant differences were seen in any haematological, serum chemistry, or radiological assessments between the ebselen groups and the placebo group. Treatment with ebselen was safe and effective at a dose of 400 mg twice daily in preventing a noise-induced TTS. These data lend support to a role of GPx1 activity in acute noise-induced hearing loss.

#Cardiovascular conditions, #hearing difficulty, and occupational #noise exposure within US industries and occupations

https://onlinelibrary.wiley.com/doi/full/10.1002/ajim.22833


Results
Twenty‐five percent of current workers had a history of occupational noise exposure (14% exposed in the last year), 12% had hearing difficulty, 24% had hypertension, 28% had elevated cholesterol; 58%, 14%, and 9% of these cases can be attributed to occupational noise exposure, respectively.

Conclusions
Hypertension, elevated cholesterol, and hearing difficulty are more prevalent among noise‐exposed workers. Reducing workplace noise levels is critical. Workplace‐based health and wellness programs should also be considered.

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Bilateral high-frequency hearing loss is associated with elevated blood #pressure and increased hypertension risk in occupational #noise exposed workers

..bilateral high-frequency hearing loss (BHFHL)

Increasing years of occupational noise exposure and BHFHL were significantly associated with systolic and diastolic blood pressure increase (all P<0.001). The lineal trend was only significant in males, with adjusted ORs for hypertension gradually increasing with increasing years of occupational noise exposure (P<0.001). Furthermore, subjects having mild and high BHFHL had a higher hypertension risk of 34% and 281%, respectively (both P<0.001). Dose-response relationship between BHFHL and hypertension was found in both males and females.

Conclusions
Occupational noise exposure was positively associated with blood pressure levels and hypertension risk.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0222135

Residential exposure to transportation #noise in Denmark and incidence of #dementia: national cohort study

https://2medical.news/2021/09/16/residential-exposure-to-transportation-noise-in-denmark-and-incidence-of-dementia-national-cohort-study/