Hepatitis B virus #core -related antigen levels predict progression to liver #cirrhosis in hepatitis B carriers
http://onlinelibrary.wiley.com/doi/10.1111/jgh.13989/full
Several hepatitis B virus (HBV) markers have been identified as risk factors for progression to liver cirrhosis in patients with chronic HBV infection. We clarified the predictive impact of HBV markers on progression to cirrhosis in HBV carriers
Eighty-four patients progressed to cirrhosis (FIB-4 index >3.6) during the follow-up period. Hepatitis B surface antigen (HBsAg), HBV DNA, hepatitis B virus core-related antigen (HBcrAg), and basal core promoter (BCP) status, but not genotype and precure status, were significantly associated with progression to cirrhosis in univariate Cox proportional hazards models. Multivariate Cox proportional hazards models adjusted for HBV genotype, HBsAg, HBV DNA, HBcrAg, precore status, and BCP status indicated that HBsAg ≥3.0 log IU/ml (HR, 0.53; 95% confidence interval (CI), 0.30–0.94) and HBcrAg ≥3.7 log U/ml (HR, 3.28; 95% CI, 1.60–6.75) are independently associated with progression to cirrhosis. In the HR spline curve analysis, HR and 95% CI gradually increased as HBcrAg levels increased. Conversely, HRs and 95% CIs for HBsAg and HBV DNA did not show this tendency as their levels increased.
Conclusions
Elevated HBcrAg levels in HBV carriers increases the risk for progression to cirrhosis. HBcrAg is an excellent predictor of the development of cirrhosis
http://onlinelibrary.wiley.com/doi/10.1111/jgh.13989/full
Several hepatitis B virus (HBV) markers have been identified as risk factors for progression to liver cirrhosis in patients with chronic HBV infection. We clarified the predictive impact of HBV markers on progression to cirrhosis in HBV carriers
Eighty-four patients progressed to cirrhosis (FIB-4 index >3.6) during the follow-up period. Hepatitis B surface antigen (HBsAg), HBV DNA, hepatitis B virus core-related antigen (HBcrAg), and basal core promoter (BCP) status, but not genotype and precure status, were significantly associated with progression to cirrhosis in univariate Cox proportional hazards models. Multivariate Cox proportional hazards models adjusted for HBV genotype, HBsAg, HBV DNA, HBcrAg, precore status, and BCP status indicated that HBsAg ≥3.0 log IU/ml (HR, 0.53; 95% confidence interval (CI), 0.30–0.94) and HBcrAg ≥3.7 log U/ml (HR, 3.28; 95% CI, 1.60–6.75) are independently associated with progression to cirrhosis. In the HR spline curve analysis, HR and 95% CI gradually increased as HBcrAg levels increased. Conversely, HRs and 95% CIs for HBsAg and HBV DNA did not show this tendency as their levels increased.
Conclusions
Elevated HBcrAg levels in HBV carriers increases the risk for progression to cirrhosis. HBcrAg is an excellent predictor of the development of cirrhosis
Serum hepatitis B #core‐related antigen level stratifies risk of disease progression in chronic #hepatitis B patients with intermediate viral load
https://2medical.news/2021/01/28/serum-hepatitis-b-core%E2%80%90related-antigen-level-stratifies-risk-of-disease-progression-in-chronic-hepatitis-b-patients-with-intermediate-viral-load/
Patients with chronic hepatitis B virus (HBV) infection are at risk of developing liver disease. Serum hepatitis B core‐related antigen (HBcrAg) is a new biomarker for intrahepatic templates for HBV replication.. ..A total of 1673 treatment‐naïve, non‐cirrhotic patients with negative hepatitis B e antigen (HBeAg) and alanine aminotransferase (ALT) level <40 U/L at baseline were enrolled. We explored the relationship between baseline levels of HBcrAg …
https://2medical.news/2021/01/28/serum-hepatitis-b-core%E2%80%90related-antigen-level-stratifies-risk-of-disease-progression-in-chronic-hepatitis-b-patients-with-intermediate-viral-load/
Patients with chronic hepatitis B virus (HBV) infection are at risk of developing liver disease. Serum hepatitis B core‐related antigen (HBcrAg) is a new biomarker for intrahepatic templates for HBV replication.. ..A total of 1673 treatment‐naïve, non‐cirrhotic patients with negative hepatitis B e antigen (HBeAg) and alanine aminotransferase (ALT) level <40 U/L at baseline were enrolled. We explored the relationship between baseline levels of HBcrAg …