#Sarcopenia and its clinical correlates in the general population: the Rotterdam Study

http://onlinelibrary.wiley.com/doi/10.1002/jbmr.3416/full

There were no statistical differences in the prevalence of chronic diseases, with the exception of a higher prevalence of COPD in pre-sarcopenic (29.1%) and sarcopenic (26.9%) individuals compared to non sarcopenic (13.4%) individuals. Osteoporotic individuals with (OR = 2.59, 95%CI:1.41-4.45) and without sarcopenia (OR = 2.75, 95%CI: 2.01-3.75) had similar elevated risk of non-vertebral fractures. The presence of sarcopenia appears to be independent of chronic diseases with the exception of COPD and more related to life-style factors and disabilities. Sarcopenic individuals in the general population are at no greater risk of fracture than what is determined by their low BMD

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A high serum #cortisol/DHEA-S ratio is a risk factor for #sarcopenia in elderly #diabetic patients

https://academic.oup.com/jes/advance-article/doi/10.1210/js.2018-00271/5368377

Elderly patients with type 2 diabetes mellitus (T2DM) have a high prevalence of frailty and/or sarcopenia. Sarcopenia is thought to be related to discordant secretions of the adrenal hormones cortisol and dehydroepiandrosterone, and the sulfate ester of dehydroepiandrosterone (DHEA-S). The present study aimed to evaluate the risk factors for sarcopenia in elderly patients with T2DM.

Multiple regression analysis showed that the independent risk factors for sarcopenia were a serum cortisol/DHEA-S ratio ≥0.2, diastolic blood pressure <70 mmHg, hemoglobin concentration <13 g/dL, and an ankle brachial index <1.0. The strongest risk factor for sarcopenia was a serum cortisol/DHEA-S ratio ≥0.2. An increase in the serum cortisol/DHEA-S ratio reflected higher cortisol values and lower DHEA-S values in patients with sarcopenia compared with those in non-sarcopenic patients. The concentrations of cortisol and DHEA-S, and the cortisol/DHEA-S ratio changed in accordance with the severity of sarcopenia.

Conclusions
A relative increase in cortisol may reflect the presence of stress and stimulate muscle catabolism, while a relative decrease in DHEA-S may cause a decrease in the anabolic action of DHEA on muscle; the combination of these factors may lead to sarcopenia

#Sarcopenia is independently associated with #parietal atrophy in older adults

https://2medical.news/2021/05/12/sarcopenia-is-independently-associated-with-parietal-atrophy-in-older-adults/

Number of #teeth and masticatory function are associated with #sarcopenia and #diabetes mellitus status among community-dwelling older adults: A Shimane CoHRE study

https://2medical.news/2021/06/11/number-of-teeth-and-masticatory-function-are-associated-with-sarcopenia-and-diabetes-mellitus-status-among-community-dwelling-older-adults-a-shimane-cohre-study/

#Sarcopenia and Sarcopenic #Obesity and Mortality Among Older People

https://2medical.news/2024/04/02/sarcopenia-and-sarcopenic-obesity-and-mortality-among-older-people/