Dietary Marine ω-3 Fatty Acids and Incident Sight-Threatening #Retinopathy in Middle-Aged and Older Individuals With Type 2 #Diabetes
http://archopht.jamanetwork.com/mobile/article.aspx?articleid=2543478
Conclusions and Relevance In middle-aged and older individuals with type 2 diabetes, intake of at least 500 mg/d of dietary LCω3PUFA, easily achievable with 2 weekly servings of oily fish, is associated with a decreased risk of sight-threatening DR. Our results concur with findings from experimental models and the current model of DR pathogenesis.
http://archopht.jamanetwork.com/mobile/article.aspx?articleid=2543478
Conclusions and Relevance In middle-aged and older individuals with type 2 diabetes, intake of at least 500 mg/d of dietary LCω3PUFA, easily achievable with 2 weekly servings of oily fish, is associated with a decreased risk of sight-threatening DR. Our results concur with findings from experimental models and the current model of DR pathogenesis.
Jamanetwork
ω-3 Fatty Acids and Diabetic Retinopathy
This study evaluates whether long-chain ω-3 polyunsaturated fatty acids intake relates to a decreased incidence of sight-threatening diabetic retinopathy in individuals older than 55 years with type 2 diabetes.
Global Estimates on the Number of People #Blind or Visually Impaired by Diabetic #Retinopathy: A Meta-analysis From 1990 to 2010
http://care.diabetesjournals.org/content/39/9/1643
CONCLUSIONS The number of persons with visual impairment due to DR worldwide is rising and represents an increasing proportion of all blindness/MSVI causes. Age-standardized prevalence of DR-related blindness/MSVI was higher in sub-Saharan Africa and South Asia. One out of 39 blind people had blindness due to DR, and 1 out of 52 visually impaired people had visual impairment due to DR.
http://care.diabetesjournals.org/content/39/9/1643
CONCLUSIONS The number of persons with visual impairment due to DR worldwide is rising and represents an increasing proportion of all blindness/MSVI causes. Age-standardized prevalence of DR-related blindness/MSVI was higher in sub-Saharan Africa and South Asia. One out of 39 blind people had blindness due to DR, and 1 out of 52 visually impaired people had visual impairment due to DR.
Diabetes Care
Global Estimates on the Number of People Blind or Visually Impaired by Diabetic Retinopathy: A Meta-analysis From 1990 to 2010
OBJECTIVE To estimate global and regional trends from 1990 to 2010 of the prevalence and number of persons visually impaired specifically by diabetic retinopathy (DR), as a complication of the precipitous trends in global diabetes, is fundamental for health…
Clinical practice guidelines
#Diabetic #Retinopathy PPP - Updated 2016
https://www.aao.org/preferred-practice-pattern/diabetic-retinopathy-ppp-updated-2016
Preferred Practice Pattern® guidelines should be clinically relevant and specific enough to provide useful information to practitioners. Where evidence exists to support a recommendation for care, the recommendation should be given an explicit rating that shows the strength of evidence.
#Diabetic #Retinopathy PPP - Updated 2016
https://www.aao.org/preferred-practice-pattern/diabetic-retinopathy-ppp-updated-2016
Preferred Practice Pattern® guidelines should be clinically relevant and specific enough to provide useful information to practitioners. Where evidence exists to support a recommendation for care, the recommendation should be given an explicit rating that shows the strength of evidence.
#Diabetic #Retinopathy: A Position Statement by the American Diabetes Association
http://care.diabetesjournals.org/content/40/3/412
Optimize glycemic control to reduce the risk or slow the progression of diabetic retinopathy. A
Optimize blood pressure and serum lipid control to reduce the risk or slow the progression of diabetic retinopathy. A
Promptly refer patients with any level of macular edema, severe nonproliferative diabetic retinopathy (a precursor of proliferative diabetic retinopathy), or any proliferative diabetic retinopathy to an ophthalmologist who is knowledgeable and experienced in the management and treatment of diabetic retinopathy. A
Laser photocoagulation therapy reduces the risk of vision loss in patients with high-risk proliferative diabetic retinopathy and, in some cases, severe nonproliferative diabetic retinopathy. A
Intravitreous injections of anti–vascular endothelial growth factor are indicated for central-involved diabetic macular edema, which occurs beneath the foveal center and may threaten reading vision. A
The presence of retinopathy is not a contraindication to aspirin therapy for cardioprotection, as aspirin does not increase the risk of retinal hemorrhage. A
http://care.diabetesjournals.org/content/40/3/412
Optimize glycemic control to reduce the risk or slow the progression of diabetic retinopathy. A
Optimize blood pressure and serum lipid control to reduce the risk or slow the progression of diabetic retinopathy. A
Promptly refer patients with any level of macular edema, severe nonproliferative diabetic retinopathy (a precursor of proliferative diabetic retinopathy), or any proliferative diabetic retinopathy to an ophthalmologist who is knowledgeable and experienced in the management and treatment of diabetic retinopathy. A
Laser photocoagulation therapy reduces the risk of vision loss in patients with high-risk proliferative diabetic retinopathy and, in some cases, severe nonproliferative diabetic retinopathy. A
Intravitreous injections of anti–vascular endothelial growth factor are indicated for central-involved diabetic macular edema, which occurs beneath the foveal center and may threaten reading vision. A
The presence of retinopathy is not a contraindication to aspirin therapy for cardioprotection, as aspirin does not increase the risk of retinal hemorrhage. A
Diabetes Care
Diabetic Retinopathy: A Position Statement by the American Diabetes Association
Diabetic retinopathy diagnostic assessment and treatment options have improved dramatically since the 2002 American Diabetes Association Position Statement (1). These improvements include the widespread adoption of optical coherence tomography to assess retinal…
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Diet #soft drink is associated with increased odds of proliferative diabetic #retinopathy
https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.13154
.Results:Of the 609 participants (mean age stan-dard deviation: 64.6 11.6 years; males = 210),285 (46.8%) and 190 (31.2%) consumed diet andregular soft drink, respectively. A total of230 (37.8%), 36 (5.9%), 154 (25.3%), 28 (4.6%)and 146 (24.0%) had no DR, mild non-proliferative DR (NPDR), moderate NPDR, severeNPDR and proliferative DR (PDR), respectively.High diet soft drink consumption was indepen-dently associated with increased likelihood ofhaving PDR (odds ratio = 2.51, 95% confidenceinterval = 1.05–5.98), compared to no consump-tion. In contrast, regular soft drink was not associ-ated with DR or DME.Conclusions and Relevance:Consuming >4 cans(1.5 L)/week of diet soft drink is associated with amore than twofold risk of having PDR in patientswith diabetes. Longitudinal studies are needed tofurther elucidate the association and its underpinning mechanism
Diet #soft drink is associated with increased odds of proliferative diabetic #retinopathy
https://onlinelibrary.wiley.com/doi/epdf/10.1111/ceo.13154
.Results:Of the 609 participants (mean age stan-dard deviation: 64.6 11.6 years; males = 210),285 (46.8%) and 190 (31.2%) consumed diet andregular soft drink, respectively. A total of230 (37.8%), 36 (5.9%), 154 (25.3%), 28 (4.6%)and 146 (24.0%) had no DR, mild non-proliferative DR (NPDR), moderate NPDR, severeNPDR and proliferative DR (PDR), respectively.High diet soft drink consumption was indepen-dently associated with increased likelihood ofhaving PDR (odds ratio = 2.51, 95% confidenceinterval = 1.05–5.98), compared to no consump-tion. In contrast, regular soft drink was not associ-ated with DR or DME.Conclusions and Relevance:Consuming >4 cans(1.5 L)/week of diet soft drink is associated with amore than twofold risk of having PDR in patientswith diabetes. Longitudinal studies are needed tofurther elucidate the association and its underpinning mechanism
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Association of #Statin Therapy With Prevention of Vision-Threatening Diabetic #Retinopathy
https://jamanetwork.com/journals/jamaophthalmology/article-abstract/2720491
Patients in the statin group had a significantly lower rate of diabetic retinopathy nonproliferative diabetic retinopathy (HR, 0.92; 95% CI, 0.86-0.99), proliferative diabetic retinopathy vitreous hemorrhage (HR, 0.62; 95% CI, 0.54-0.71), tractional retinal detachment (HR, 0.61; 95% CI, 0.47-0.79), and macular edema (HR, 0.60; 95% CI, 0.46-0.79) than the nonstatin group, as well as lower rates of interventions such as retinal laser treatment (HR, 0.71; 95% CI, 0.65-0.77), intravitreal injection (HR, 0.74; 95% CI, 0.61-0.89), and vitrectomy (HR, 0.58; 95% CI, 0.48-0.69), along with a smaller number of the interventions (retinal lasers: rate ratio, 0.61; 95% CI, 0.59-0.64; intravitreal injections: rate ratio, 0.68; 95% CI, 0.61-0.76; and vitrectomies: rate ratio, 0.54; 95% CI, 0.46-0.63). Statin therapy was also associated with lower risks of major adverse cardiovascular events (HR, 0.81; 95% CI, 0.77-0.85), new-onset diabetic neuropathy (HR, 0.85; 95% CI, 0.82-0.89), and new-onset diabetic foot ulcers (HR, 0.73; 95% CI, 0.68-0.78).
Conclusions and Relevance Statin therapy was associated with a decreased risk of diabetic retinopathy and need for treatments for vision-threatening diabetic retinopathy in Taiwanese patients with type 2 diabetes and dyslipidemia.
Association of #Statin Therapy With Prevention of Vision-Threatening Diabetic #Retinopathy
https://jamanetwork.com/journals/jamaophthalmology/article-abstract/2720491
Patients in the statin group had a significantly lower rate of diabetic retinopathy nonproliferative diabetic retinopathy (HR, 0.92; 95% CI, 0.86-0.99), proliferative diabetic retinopathy vitreous hemorrhage (HR, 0.62; 95% CI, 0.54-0.71), tractional retinal detachment (HR, 0.61; 95% CI, 0.47-0.79), and macular edema (HR, 0.60; 95% CI, 0.46-0.79) than the nonstatin group, as well as lower rates of interventions such as retinal laser treatment (HR, 0.71; 95% CI, 0.65-0.77), intravitreal injection (HR, 0.74; 95% CI, 0.61-0.89), and vitrectomy (HR, 0.58; 95% CI, 0.48-0.69), along with a smaller number of the interventions (retinal lasers: rate ratio, 0.61; 95% CI, 0.59-0.64; intravitreal injections: rate ratio, 0.68; 95% CI, 0.61-0.76; and vitrectomies: rate ratio, 0.54; 95% CI, 0.46-0.63). Statin therapy was also associated with lower risks of major adverse cardiovascular events (HR, 0.81; 95% CI, 0.77-0.85), new-onset diabetic neuropathy (HR, 0.85; 95% CI, 0.82-0.89), and new-onset diabetic foot ulcers (HR, 0.73; 95% CI, 0.68-0.78).
Conclusions and Relevance Statin therapy was associated with a decreased risk of diabetic retinopathy and need for treatments for vision-threatening diabetic retinopathy in Taiwanese patients with type 2 diabetes and dyslipidemia.
Five-Year Patterns of #Diabetic #Retinopathy Progression in US Clinical Practice
https://2medical.news/2020/11/04/five-year-patterns-of-diabetic-retinopathy-progression-in-us-clinical-practice/
To characterize the natural course of diabetic retinopathy (DR) in contemporary clinical practice. Patients and Methods: This was a retrospective analysis of US claims data collected between January 1, 2006, and April 30, 2017. Patients aged ≥ 18 years with continuous medical and prescription insurance coverage for 18 months before DR diagnosis (index date) and for a follow-up period of 5 years were included (N=14,490). …
https://2medical.news/2020/11/04/five-year-patterns-of-diabetic-retinopathy-progression-in-us-clinical-practice/
To characterize the natural course of diabetic retinopathy (DR) in contemporary clinical practice. Patients and Methods: This was a retrospective analysis of US claims data collected between January 1, 2006, and April 30, 2017. Patients aged ≥ 18 years with continuous medical and prescription insurance coverage for 18 months before DR diagnosis (index date) and for a follow-up period of 5 years were included (N=14,490). …
Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
https://2medical.news/2021/02/21/association-of-gastric-bypass-surgery-with-risk-of-developing-diabetic-retinopathy-among-patients-with-obesity-and-type-2-diabetes-in-sweden/
Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a matched cohort of patients with obesity and diabetes who have …
https://2medical.news/2021/02/21/association-of-gastric-bypass-surgery-with-risk-of-developing-diabetic-retinopathy-among-patients-with-obesity-and-type-2-diabetes-in-sweden/
Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a matched cohort of patients with obesity and diabetes who have …