#Prevalence of #HPV in Adults Aged 18–69: United States, 2011–2014
https://www.cdc.gov/nchs/products/databriefs/db280.htm During 2011–2014, prevalence of any oral human papillomavirus (HPV) for adults aged 18–69 was 7.3%; high-risk HPV was 4.0%.
Overall, prevalence of any and high-risk oral HPV was lowest among non-Hispanic Asian adults; any oral HPV was highest among non-Hispanic black adults.
Prevalence of any and high-risk oral HPV was higher in men than women except for high-risk HPV among Asian adults.
During 2013–2014, prevalence of any and high-risk genital HPV for adults aged 18–59 was 45.2% and 25.1% in men and 39.9% and 20.4% in women, respectively.
Prevalence of any and high-risk genital HPV was lower among non-Hispanic Asian and higher among non-Hispanic black than both non-Hispanic white and Hispanic men and women.
https://www.cdc.gov/nchs/products/databriefs/db280.htm During 2011–2014, prevalence of any oral human papillomavirus (HPV) for adults aged 18–69 was 7.3%; high-risk HPV was 4.0%.
Overall, prevalence of any and high-risk oral HPV was lowest among non-Hispanic Asian adults; any oral HPV was highest among non-Hispanic black adults.
Prevalence of any and high-risk oral HPV was higher in men than women except for high-risk HPV among Asian adults.
During 2013–2014, prevalence of any and high-risk genital HPV for adults aged 18–59 was 45.2% and 25.1% in men and 39.9% and 20.4% in women, respectively.
Prevalence of any and high-risk genital HPV was lower among non-Hispanic Asian and higher among non-Hispanic black than both non-Hispanic white and Hispanic men and women.
www.cdc.gov
Products - Data Briefs - Number 280 - April 2017
Prevalence of HPV in Adults Aged 18–69: United States, 2011–2014
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Trends in Risks for Second Primary Cancers Associated With Index Human #Papillomavirus –Associated Cancers
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2701740
From 113 272 (73 085 female and 40 187 male) survivors of #HPV -associated cancers, 1397 women and 1098 men developed HPV-SPCs. The SIRs for HPV-SPCs were 6.2 (95% CI, 5.9-6.6) among women and 15.8 (95% CI, 14.9-16.8) among men. The EARs were 18.2 per 10 000 PYR for women and 53.5 per 10 000 PYR for men. Among both women and men, those who had index oropharyngeal cancers had the highest HPV-SPC risk (SIR, 19.8 95% CI, 18.4-21.4 and EAR, 80.6 per 10 000 PYR among women; SIR, 18.0 95% CI, 16.9-19.1 and EAR, 61.5 per 10 000 PYR among men). Women who had index cervical cancers and men who had index anal cancers had the lowest HPV-SPC risk (SIR, 2.4 95% CI, 2.2-2.7 and EAR, 4.5 per 10 000 PYR among women; SIR, 6.5 95% CI, 4.7-8.8 and EAR, 18.5 per 10 000 PYR among men). Both women and men who had index HPV-associated cancers of any kind had a significantly higher risk of oropharyngeal HPV-SPCs. Over the last 4 decades, the risk of developing most types of HPV-SPCs after index cervical, vaginal, and vulvar cancers increased.
Conclusions and Relevance According to this study, the HPV-SPC risk among survivors of HPV-associated cancers is significant, implying that persistent HPV infection at multiple sites may be associated with HPV-SPCs. These findings have the potential to inform surveillance recommendations for survivors of HPV-associated cancers
Trends in Risks for Second Primary Cancers Associated With Index Human #Papillomavirus –Associated Cancers
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2701740
From 113 272 (73 085 female and 40 187 male) survivors of #HPV -associated cancers, 1397 women and 1098 men developed HPV-SPCs. The SIRs for HPV-SPCs were 6.2 (95% CI, 5.9-6.6) among women and 15.8 (95% CI, 14.9-16.8) among men. The EARs were 18.2 per 10 000 PYR for women and 53.5 per 10 000 PYR for men. Among both women and men, those who had index oropharyngeal cancers had the highest HPV-SPC risk (SIR, 19.8 95% CI, 18.4-21.4 and EAR, 80.6 per 10 000 PYR among women; SIR, 18.0 95% CI, 16.9-19.1 and EAR, 61.5 per 10 000 PYR among men). Women who had index cervical cancers and men who had index anal cancers had the lowest HPV-SPC risk (SIR, 2.4 95% CI, 2.2-2.7 and EAR, 4.5 per 10 000 PYR among women; SIR, 6.5 95% CI, 4.7-8.8 and EAR, 18.5 per 10 000 PYR among men). Both women and men who had index HPV-associated cancers of any kind had a significantly higher risk of oropharyngeal HPV-SPCs. Over the last 4 decades, the risk of developing most types of HPV-SPCs after index cervical, vaginal, and vulvar cancers increased.
Conclusions and Relevance According to this study, the HPV-SPC risk among survivors of HPV-associated cancers is significant, implying that persistent HPV infection at multiple sites may be associated with HPV-SPCs. These findings have the potential to inform surveillance recommendations for survivors of HPV-associated cancers
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#Vorinostat, a pan-HDAC inhibitor, abrogates productive #HPV-18 DNA amplification
http://www.pnas.org/content/115/47/E11138
Human papillomaviruses (HPVs) cause epithelial proliferative diseases. Persistent infection of the mucosal epithelia by the high-risk genotypes can progress to high-grade dysplasia and cancers.
Viral transcription and protein activities are intimately linked to regulation by histone acetyltransferases and histone deacetylases (HDACs) that remodel chromatin and regulate gene expression. HDACs are also essential to remodel and repair replicating chromatin to enable the progression of replication forks.
As such, Vorinostat (suberoylanilide hydroximic acid), and other pan-HDAC inhibitors, are used to treat lymphomas.
..We suggest that HDAC inhibitors are promising therapeutic agents to treat benign HPV infections, abrogate progeny virus production, and hence interrupt transmission.
#Vorinostat, a pan-HDAC inhibitor, abrogates productive #HPV-18 DNA amplification
http://www.pnas.org/content/115/47/E11138
Human papillomaviruses (HPVs) cause epithelial proliferative diseases. Persistent infection of the mucosal epithelia by the high-risk genotypes can progress to high-grade dysplasia and cancers.
Viral transcription and protein activities are intimately linked to regulation by histone acetyltransferases and histone deacetylases (HDACs) that remodel chromatin and regulate gene expression. HDACs are also essential to remodel and repair replicating chromatin to enable the progression of replication forks.
As such, Vorinostat (suberoylanilide hydroximic acid), and other pan-HDAC inhibitors, are used to treat lymphomas.
..We suggest that HDAC inhibitors are promising therapeutic agents to treat benign HPV infections, abrogate progeny virus production, and hence interrupt transmission.
PNAS
Vorinostat, a pan-HDAC inhibitor, abrogates productive HPV-18 DNA amplification
Persistent infection by the high-risk human papillomaviruses (HPVs) can lead to anogenital and head and neck cancers. The HPV vaccines effectively prevent new type-restricted infections but have no effect on preexisting infections. It is crucial to identify…
#HPV Vaccination and the Risk of Invasive #Cervical Cancer
https://2medical.news/2020/10/07/hpv-vaccination-and-the-risk-of-invasive-cervical-cancer/
The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform the relationship between quadrivalent HPV vaccination and the subsequent risk of invasive cervical cancer are lacking.. ..During the study period, we evaluated girls and women for cervical cancer until their 31st birthday. Cervical cancer was diagnosed in 19 women who had received …
https://2medical.news/2020/10/07/hpv-vaccination-and-the-risk-of-invasive-cervical-cancer/
The efficacy and effectiveness of the quadrivalent human papillomavirus (HPV) vaccine in preventing high-grade cervical lesions have been shown. However, data to inform the relationship between quadrivalent HPV vaccination and the subsequent risk of invasive cervical cancer are lacking.. ..During the study period, we evaluated girls and women for cervical cancer until their 31st birthday. Cervical cancer was diagnosed in 19 women who had received …