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Aldo Lorenzetti M.D, Internal Medicine & Hepatology, Milano - SIMEDET Delegate
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#Alcohol Consumption, Left #Atrial Diameter, and Atrial Fibrillation

http://m.jaha.ahajournals.org/content/5/9/e004060.full

Conclusions Our study of a large, community‐based sample identified alcohol consumption as a predictor of left atrial enlargement and subsequent incident AF. Left atrial enlargement may be an intermediate phenotype along the causal pathway linking long‐term alcohol consumption to AF.
C-LBCT02-03 - EWOLUTION trial: 1-Year Efficacy and Safety of Left #Atrial Appendage Closure with WATCHMAN in Patients with or without Contraindication to Oral #Anticoagulation
http://www.abstractsonline.com/pp8/#!/4227/presentation/12994

Methods: 1025 pts scheduled for a WATCHMAN implant were prospectively and sequentially (83% of sites) enrolled at 47 centers. Indication for LAAC was based on ESC guidelines at the discretion of the individual centers. Follow-up and TEE were performed per local practice. Events are given as Kaplan-Meier event rates.

Conclusion: LAA closure with the WATCHMAN device has a high implant and sealing success. Stroke prevention appears to be safe and effective with an ischemic stroke rate as low as 1.2%, even though more than 73% of pts had a contra-indication to and were not using OAC
Clinical Outcomes Associated With Left #Atrial Appendage Occlusion Versus Direct Oral #Anticoagulation in Atrial #Fibrillation
https://2medical.news/2021/01/15/clinical-outcomes-associated-with-left-atrial-appendage-occlusion-versus-direct-oral-anticoagulation-in-atrial-fibrillation/

This study sought to investigate clinical outcomes associated with left atrial appendage occlusion (LAAO) versus direct oral anticoagulants (DOACs) in patients with high-risk atrial fibrillation (AF).. ..Patients with AF enrolled in the Amulet Observational Registry (n = 1,088) who had successful LAAO with the Amplatzer Amulet device (n = 1,078) were compared with a propensity score–matched control cohort of incident AF patients (n = 1,184) …