#Autoimmune diseases in adults with #atopic dermatitis

http://www.sciencedirect.com/science/article/pii/S0190962216307344

Our results suggest a susceptibility of autoimmune diseases in adult patients with AD, especially in smokers. While we cannot conclude on causality based on these data, an increased awareness of autoimmune comorbidities in patients with AD may be warranted.

#Atopic dermatitis and #psoriasis: two different immune diseases or one spectrum?
http://www.sciencedirect.com/science/article/pii/S0952791517301061

Highlights
•Psoriasis and AD are diseases of distinct T-cell ‘polar’ subsets.

•Targeting Th17/IL-17 is an extremely effective treatment for psoriasis.

•Targeting Th2/IL-4 & IL-13 is a highly effective treatment for atopic dermatitis.

•However, specific sub-types of atopic dermatitis blend Th17 and Th2 cytokine axes.

•Optimal treatment of AD across subtypes might require targeting multiple cytokines.

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Severe and predominantly active #atopic eczema in adulthood and long term risk of #cardiovascular disease: population based cohort study

https://www.bmj.com/content/361/bmj.k1786


Patients with severe atopic eczema had a 20% increase in the risk of stroke (hazard ratio 1.22, 99% confidence interval 1.01 to 1.48), 40% to 50% increase in the risk of myocardial infarction, unstable angina, atrial fibrillation, and cardiovascular death, and 70% increase in the risk of heart failure (hazard ratio 1.69, 99% confidence interval 1.38 to 2.06). Patients with the most active atopic eczema (active >50% of follow-up) were also at a greater risk of cardiovascular outcomes. Additional adjustment for cardiovascular risk factors as potential mediators partially attenuated the point estimates, though associations persisted for severe atopic eczema.

Conclusions Severe and predominantly active atopic eczema are associated with an increased risk of cardiovascular outcomes. Targeting cardiovascular disease prevention strategies among these patients should be considered.

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#Atopic eczema and #fracture risk in adults: A population-based cohort study

Those with eczema had increased risk of hip (HR, 1.10; 99% CI, 1.06-1.14), pelvic (HR, 1.10; 99% CI, 1.02-1.19), spinal (HR, 1.18; 99% CI, 1.10-1.27), and wrist (HR, 1.07; 99% CI, 1.03,-1.11) fractures. We found no evidence of increased proximal humeral (HR, 1.06; 99% CI, 0.97-1.15) fracture risk. Fracture risk increased with increasing eczema severity, with the strongest associations in people with severe eczema (compared with those without) for spinal (HR, 2.09; 99% CI, 1.66-2.65), pelvic (HR, 1.66; 99% CI, 1.26-2.20), and hip (HR, 1.50; 99% CI, 1.30-1.74) fractures. Associations persisted after oral glucocorticoid adjustment.

Conclusions
People with atopic eczema have increased fracture risk, particularly major osteoporotic fractures.

https://www.jacionline.org/article/S0091-6749(19)31251-5/fulltext

Association Between #Atopic Eczema and #Cancer in England and Denmark
https://2medical.news/2020/10/19/association-between-atopic-eczema-and-cancer-in-england-and-denmark/

Associations between atopic eczema and cancer are unclear, with competing theories that increased immune surveillance decreases cancer risk and that immune stimulation increases cancer risk. Establishing baseline cancer risk in people with atopic eczema is important before exploring the association between new biologic drugs for atopic eczema and cancer risk.. ..In England, matched cohorts included 471 970 individuals with atopic eczema (median [IQR] age, 41.1 [24.9-60.7] …

Risk of #Inflammatory #Bowel Disease in Patients With #Atopic Dermatitis

https://2medical.news/2023/09/16/risk-of-inflammatory-bowel-disease-in-patients-with-atopic-dermatitis/

#ATOPIC DERMATITIS PATIENT EXPERIENCE WITH DISCUSSING AND ADDRESSING MENTAL HEALTH CONCERNS WITH ALLERGISTS

https://2medical.news/2024/01/13/atopic-dermatitis-patient-experience-with-discussing-and-addressing-mental-health-concerns-with-allergists/

#Sodium Intake and #Atopic Dermatitis

https://2medical.news/2024/06/13/sodium-intake-and-atopic-dermatitis/