Healthy #lifestyle and the risk of #Alzheimer dementia
https://2medical.news/2020/06/26/healthy-lifestyle-and-the-risk-of-alzheimer-dementia/

Using data from the Chicago Health and Aging Project (CHAP; n = 1,845) and the Rush Memory and Aging Project (MAP; n = 920), we defined a healthy lifestyle score on the basis of nonsmoking, ≥150 min/wk moderate/vigorous-intensity physical activity, light to moderate alcohol consumption, high-quality Mediterranean-DASH Diet.. ..During a median follow-up of 5.8 years in CHAP and 6.0 years in MAP, 379 and 229 …

CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of #Alzheimer’s disease
https://2medical.news/2020/08/19/cms121-a-fatty-acid-synthase-inhibitor-protects-against-excess-lipid-peroxidation-and-inflammation-and-alleviates-cognitive-loss-in-a-transgenic-mouse-model-of-alzheimers-disease/

The oxidative degradation of lipids has been shown to be implicated in the progression of several neurodegenerative diseases and modulating lipid peroxidation may be efficacious for treating Alzheimer’s disease (AD). This hypothesis is strengthened by recent findings suggesting that oxytosis/ferroptosis, a cell death process characterized by increased lipid peroxidation, plays an important role in AD-related toxicities. CMS121 is a small molecule developed against these aspects …

#Depression and increased risk of #Alzheimer’s #dementia: longitudinal analyses of modifiable risk and sex-related factors.
https://2medical.news/2021/01/11/depression-and-increased-risk-of-alzheimers-dementia-longitudinal-analyses-of-modifiable-risk-and-sex-related-factors/

Highlights •We investigated whether recent and/or remote depression was associated with increased risk of Alzheimer’s Dementia (AD) and whether this risk differed between men and women. •Recent depression was independently associated with increased risk of incident AD while remote depression was not. Recent depression was predictive of AD development in females, but not in males, while sex did not moderate recent depression-associated risk of developing …

#Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease
https://2medical.news/2021/02/22/physical-activity-may-not-be-associated-with-long%E2%80%90term-risk-of-dementia-and-alzheimers-disease/

While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer’s disease (AD). Material and methods We analysed data on 2394 apparently healthy men with good baseline …

Clinical and Biological Correlates of White Matter Hyperintensities in Patients with #Behavioral-variant Frontotemporal #Dementia and #Alzheimer Disease
https://2medical.news/2021/02/27/clinical-and-biological-correlates-of-white-matter-hyperintensities-in-patients-with-behavioral-variant-frontotemporal-dementia-and-alzheimer-disease/

To test the hypothesis that white matter hyperintensities (WMH) in behavioral-variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD) are associated with disease variables such as disease severity, cortical atrophy and cognition, we conducted a cross-sectional brain MRI study with volumetric and voxel-wise analyses. Methods: 129 patients (64 bvFTD, 65 AD) and 66 controls underwent high-resolution brain MRI, clinical and neuropsychological examination. Genetic screening was conducted …

Low Doses of Ionizing #Radiation as a Treatment for #Alzheimer’s Disease: A Pilot Study

https://2medical.news/2021/05/07/low-doses-of-ionizing-radiation-as-a-treatment-for-alzheimers-disease-a-pilot-study/

#Mediterranean Diet, #Alzheimer Disease Biomarkers and #Brain Atrophy in Old Age

https://2medical.news/2021/05/10/mediterranean-diet-alzheimer-disease-biomarkers-and-brain-atrophy-in-old-age/

The Effects of Chronic Exposure to Ambient #Traffic-Related Air #Pollution on #Alzheimer’s Disease Phenotypes in Wildtype and Genetically Predisposed Male and Female Rats

https://2medical.news/2021/05/26/the-effects-of-chronic-exposure-to-ambient-traffic-related-air-pollution-on-alzheimers-disease-phenotypes-in-wildtype-and-genetically-predisposed-male-and-female-rats/

Reduced coupling between cerebrospinal fluid flow and global #brain activity is linked to #Alzheimer disease–related pathology

https://2medical.news/2021/06/08/reduced-coupling-between-cerebrospinal-fluid-flow-and-global-brain-activity-is-linked-to-alzheimer-disease-related-pathology/

#Cognitive Activity and Onset Age of Incident #Alzheimer Disease #Dementia

https://2medical.news/2021/07/21/cognitive-activity-and-onset-age-of-incident-alzheimer-disease-dementia/

Analysis of Features of #Alzheimer’s Disease: Detection of Early Stage from Functional Brain Changes in Magnetic #Resonance Images Using a Finetuned ResNet18 Network

https://2medical.news/2021/09/22/analysis-of-features-of-alzheimers-disease-detection-of-early-stage-from-functional-brain-changes-in-magnetic-resonance-images-using-a-finetuned-resnet18-network/

Spatial organization of #protein aggregates on red #blood cells as physical biomarkers of #Alzheimer’s disease pathology

https://2medical.news/2021/09/28/spatial-organization-of-protein-aggregates-on-red-blood-cells-as-physical-biomarkers-of-alzheimers-disease-pathology/

Synthesis of human #amyloid restricted to #liver results in an #Alzheimer disease–like neurodegenerative phenotype

https://2medical.news/2021/09/30/synthesis-of-human-amyloid-restricted-to-liver-results-in-an-alzheimer-disease-like-neurodegenerative-phenotype/

#Espresso Coffee Mitigates the Aggregation and Condensation of #Alzheimer′s Associated Tau Protein

https://2medical.news/2023/07/28/espresso-coffee-mitigates-the-aggregation-and-condensation-of-alzheimer%E2%80%B2s-associated-tau-protein/

Effect of apolipoprotein genotype and #educational attainment on #cognitive function in autosomal dominant #Alzheimer’s disease

https://2medical.news/2023/09/09/effect-of-apolipoprotein-genotype-and-educational-attainment-on-cognitive-function-in-autosomal-dominant-alzheimers-disease/

Clinically apparent #Helicobacter pylori infection and the risk of incident #Alzheimer’s disease: A population-based nested case-control study

https://2medical.news/2024/01/03/clinically-apparent-helicobacter-pylori-infection-and-the-risk-of-incident-alzheimers-disease-a-population-based-nested-case-control-study/

#Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study

https://2medical.news/2024/01/12/statins-and-cognitive-decline-in-patients-with-alzheimers-and-mixed-dementia-a-longitudinal-registry-based-cohort-study/

#Sildenafil as a Candidate Drug for #Alzheimer’s Disease: Real-World Patient Data Observation and Mechanistic Observations from Patient-Induced Pluripotent Stem Cell-Derived Neurons

https://2medical.news/2024/03/16/sildenafil-as-a-candidate-drug-for-alzheimers-disease-real-world-patient-data-observation-and-mechanistic-observations-from-patient-induced-pluripotent-stem-cell-derived-neurons/

Summary: A new study explores the molecular connections between Type 2 #diabetes and #Alzheimer’s, supporting the notion of Alzheimer’s as “Type 3 diabetes.”

https://2medical.news/2024/03/27/summary-a-new-study-explores-the-molecular-connections-between-type-2-diabetes-and-alzheimers-supporting-the-notion-of-alzheimers-as-type-3-diabetes/

Older adults at greater risk for #Alzheimer’s disease show stronger associations between sleep #apnea severity in #REM sleep and verbal memory

https://2medical.news/2024/05/25/older-adults-at-greater-risk-for-alzheimers-disease-show-stronger-associations-between-sleep-apnea-severity-in-rem-sleep-and-verbal-memory/