Deficiency of the hepatokine #selenoprotein P increases responsiveness to #exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle
http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4295.html

..Furthermore, we found that increased amounts of circulating SeP predicted the ineffectiveness of training on endurance capacity in humans. Our study suggests that inhibitors of the SeP–LRP1 axis may function as exercise-enhancing drugs to treat diseases associated with a sedentary lifestyle.