Phenome-Wide Association Study of #Rheumatoid Arthritis Subgroups Identifies Association between Seronegative Disease and #Fibromyalgia

http://onlinelibrary.wiley.com/wol1/doi/10.1002/art.39851/abstract

Conclusion: This PheWAS in RA patients identifies a strong association between seronegativity and fibromyalgia. It also affirms relationships between seropositivity with chronic airway obstruction and seropositivity with tobacco use. These findings demonstrate the utility of the PheWAS approach to discover novel phenotype associations within different subgroups of a disease.

#Pregabalin for pain in #fibromyalgia in adults

http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD011790.pub2/full

Pregabalin 300 to 600 mg produces a major reduction in pain intensity over 12 to 26 weeks with tolerable adverse events for a small proportion of people (about 10% more than placebo) with moderate or severe pain due to fibromyalgia. The degree of pain relief is known to be accompanied by improvements in other symptoms, quality of life, and function. These results are similar to other effective medicines in fibromyalgia (milnacipran, duloxetine).

#Fibromyalgia Predicts Two-Year Changes in Functional Status in #Rheumatoid Arthritis Patients

http://onlinelibrary.wiley.com/doi/10.1002/acr.23216/abstract

Both the presence of FM and increasing number of FM symptoms predicted worsening of functional status among individuals with RA. Among individuals with RA and FM, the magnitude of the difference in changes in MDHAQ was 4 to 7-fold higher than typical changes in MDHAQ score among individuals with established RA.

Multi-Dimensional Health Assessment Questionnaire (MDHAQ)

#Fibromyalgia and the Prediction of Two-Year Changes in Functional Status in #Rheumatoid Arthritis Patients
http://onlinelibrary.wiley.com/doi/10.1002/acr.23216/full

Of the 156 included RA subjects, 16.7% had FM, while 83.3% did not. In a multivariable linear regression model adjusted for age, sex, race, baseline MDHAQ score, disease duration, rheumatoid factor/cyclic citrullinated peptide antibody seropositivity, disease activity, and psychological distress, RA patients with FM had a 0.14 greater 2-year increase in MDHAQ score than RA patients without FM (P = 0.021). In secondary analyses examining the association between continuous PSD scale score and change in MDHAQ, higher PSD scale scores were significantly associated with greater 2-year increases in MDHAQ score (β coefficient 0.013, P = 0.011).
Conclusion

Both the presence of FM and increasing number of FM symptoms predicted worsening of functional status among individuals with RA. Among individuals with RA and FM, the magnitude of the difference in changes in MDHAQ was 4- to 7-fold higher than typical changes in MDHAQ score among individuals with established RA

A simple #screening test to recognize #fibromyalgia in primary care patients with chronic pain
https://www.ncbi.nlm.nih.gov/pubmed/29063661

Primary care providers are increasingly expected to recognize and treat fibromyalgia (FM) without significant interaction with rheumatologists. The purpose of this study was to evaluate the potential usefulness of 3 simple measures (tenderness to digital pressure, BP cuff-evoked pain, and a single patient question , "I have a persistent deep aching over most of my body" (0-10) as a screening test for possible FM in a patient with chronic pain

FM patients endorsed the single deep ache question substantially more than those with chronic pain but without FM (7.4 ± 2.9 vs 3.2 ± 3.4; P < .0001) and exhibited greater bilateral digital evoked tenderness (6.1 ± 3.1 vs 2.4 ± 2.4, P < 0.0001), and BP-evoked pressure pain (132.6 mmHg ±45.5 vs 169.2 mmHg ±48.0, P < 0.0001). However, on multivariate logistic regressions, the BP cuff-evoked pain became non-significant. On further analyses, a useful screening test was provided by: (1) pain on pinching the Achilles tendon at 4 kg/pressure over 4 seconds, and (2) and positive endorsement of the question "I have a persistent deep aching over most of my body".

CONCLUSION:
These results suggest that 2 tests, taking less than 1 minute, can indicate a probable diagnosis of FM in a chronic pain patient. In the case of a positive screen, a follow-up examination is required for confirmation or refutation.

Effect of #tai chi versus aerobic exercise for #fibromyalgia: comparative effectiveness randomized controlled trial

http://www.bmj.com/content/360/bmj.k851

Tai chi treatment compared with aerobic exercise administered with the same intensity and duration (24 weeks, twice weekly) had greater benefit (between group difference in FIQR scores=16.2 points, 8.7 to 23.6, P<0.001). The groups who received tai chi for 24 weeks showed greater improvements than those who received it for 12 weeks (difference in FIQR scores=9.6 points, 2.6 to 16.6, P=0.007). There was no significant increase in benefit for groups who received tai chi twice weekly compared with once weekly. Participants attended the tai chi training sessions more often than participants attended aerobic exercise. The effects of tai chi were consistent across all instructors. No serious adverse events related to the interventions were reported.

Conclusion Tai chi mind-body treatment results in similar or greater improvement in symptoms than aerobic exercise, the current most commonly prescribed non-drug treatment, for a variety of outcomes for patients with fibromyalgia. Longer duration of tai chi showed greater improvement. This mind-body approach may be considered a therapeutic option in the multidisciplinary management of fibromyalgia

Association of Therapies With Reduced #Pain and Improved Quality of Life in Patients With #Fibromyalgia
https://2medical.news/2020/10/29/association-of-therapies-with-reduced-pain-and-improved-quality-of-life-in-patients-with-fibromyalgia/

..To investigate the effectiveness of therapies for reducing pain and improving quality of life (QOL) in people with fibromyalgia.. ..A total of 224 trials including 29 962 participants were included. High-quality evidence was found in favor of cognitive behavioral therapy (weighted mean difference [WMD], −0.9; 95% CI, −1.4 to −0.3) for pain in the short term and was found in favor of central nervous system depressants …

Passive transfer of #fibromyalgia symptoms from patients to mice

https://2medical.news/2021/07/03/passive-transfer-of-fibromyalgia-symptoms-from-patients-to-mice/