Relationship between hair and salivary #cortisol and pregnancy in women undergoing #IVF

http://www.psyneuen-journal.com/article/S0306-4530(16)30622-9/abstract

These findings provide preliminary evidence that longer term systemic cortisol may influence reproductive outcomes; and in turn suggests that interventions to reduce cortisol prior to commencing IVF could improve treatment outcomes.

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A high serum #cortisol/DHEA-S ratio is a risk factor for #sarcopenia in elderly #diabetic patients

https://academic.oup.com/jes/advance-article/doi/10.1210/js.2018-00271/5368377

Elderly patients with type 2 diabetes mellitus (T2DM) have a high prevalence of frailty and/or sarcopenia. Sarcopenia is thought to be related to discordant secretions of the adrenal hormones cortisol and dehydroepiandrosterone, and the sulfate ester of dehydroepiandrosterone (DHEA-S). The present study aimed to evaluate the risk factors for sarcopenia in elderly patients with T2DM.

Multiple regression analysis showed that the independent risk factors for sarcopenia were a serum cortisol/DHEA-S ratio ≥0.2, diastolic blood pressure <70 mmHg, hemoglobin concentration <13 g/dL, and an ankle brachial index <1.0. The strongest risk factor for sarcopenia was a serum cortisol/DHEA-S ratio ≥0.2. An increase in the serum cortisol/DHEA-S ratio reflected higher cortisol values and lower DHEA-S values in patients with sarcopenia compared with those in non-sarcopenic patients. The concentrations of cortisol and DHEA-S, and the cortisol/DHEA-S ratio changed in accordance with the severity of sarcopenia.

Conclusions
A relative increase in cortisol may reflect the presence of stress and stimulate muscle catabolism, while a relative decrease in DHEA-S may cause a decrease in the anabolic action of DHEA on muscle; the combination of these factors may lead to sarcopenia

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Natural History of Adrenal #Incidentalomas With and Without Mild Autonomous #Cortisol Excess: A Systematic Review and Meta-analysis

https://annals.org/aim/article-abstract/2736920/natural-history-adrenal-incidentalomas-without-mild-autonomous-cortisol-excess-systematic

Adrenal incidentalomas are mostly benign nonfunctioning adrenal tumors (NFATs) or adenomas causing mild autonomous cortisol excess (MACE), but their natural history is unclear.

Clinically significant tumor enlargement (≥10 mm) occurred in 2.5% of patients, and none developed adrenal cancer. Clinically overt hormone excess was unlikely to develop (<0.1%) in patients with NFAT or MACE. Only 4.3% of patients with NFAT developed MACE, and preexisting MACE was unlikely to resolve (<0.1%). Hypertension, obesity, dyslipidemia, and type 2 diabetes were highly prevalent (60.0%, 42.0%, 33.7%, and 18.1% of patients, respectively) and were more likely to develop and worsen in MACE than NFAT. New cardiovascular events were more prevalent in MACE (15.5%) than NFAT (6.4%). Mortality was 11.2% and was similar between NFAT and MACE.

During follow-up, NFAT and MACE do not show clinically relevant changes in size or hormonal function, but they may carry an increased risk for cardiometabolic comorbid conditions.

Association Between Mortality and Levels of Autonomous #Cortisol Secretion by Adrenal #Incidentalomas

https://2medical.news/2021/05/26/association-between-mortality-and-levels-of-autonomous-cortisol-secretion-by-adrenal-incidentalomas/