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Antimicrobial resistance patterns in #urinary E. #coli isolates after a change in a single center’s guidelines for uncomplicated cystitis in ambulatory settings
https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/antimicrobial-resistance-patterns-in-urinary-e-coli-isolates-after-a-change-in-a-single-centers-guidelines-for-uncomplicated-cystitis-in-ambulatory-settings/23C0C0A814FEBF9C7D24E8045437F5D6
Recommending #nitrofurantoin to treat uncomplicated cystitis was associated with increased nitrofurantoin use from 3.53 to 4.01 prescriptions per 1,000 outpatient visits, but nitrofurantoin resistance in E. coli isolates remained stable at 2%. Concomitant levofloxacin resistance was a significant risk for nitrofurantoin resistance in E. coli isolates (odds ratio [OR], 2.72; 95% confidence interval [CI], 1.04–7.17).
Antimicrobial resistance patterns in #urinary E. #coli isolates after a change in a single center’s guidelines for uncomplicated cystitis in ambulatory settings
https://www.cambridge.org/core/journals/infection-control-and-hospital-epidemiology/article/antimicrobial-resistance-patterns-in-urinary-e-coli-isolates-after-a-change-in-a-single-centers-guidelines-for-uncomplicated-cystitis-in-ambulatory-settings/23C0C0A814FEBF9C7D24E8045437F5D6
Recommending #nitrofurantoin to treat uncomplicated cystitis was associated with increased nitrofurantoin use from 3.53 to 4.01 prescriptions per 1,000 outpatient visits, but nitrofurantoin resistance in E. coli isolates remained stable at 2%. Concomitant levofloxacin resistance was a significant risk for nitrofurantoin resistance in E. coli isolates (odds ratio [OR], 2.72; 95% confidence interval [CI], 1.04–7.17).
Cambridge Core
Antimicrobial resistance patterns in urinary E. coli isolates after a change in a single center’s guidelines for uncomplicated…
Antimicrobial resistance patterns in urinary E. coli isolates after a change in a single center’s guidelines for uncomplicated cystitis in ambulatory settings - Volume 40 Issue 5 - Patrick P. Ryan, Bryan C. Knepper, Rachel M. Everhart, Connie S. Price
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Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
Fecal microbiota transplantation (#FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor by means of genomic sequencing. One of the patients died.
Enhanced donor screening to limit the transmission of microorganisms that could lead to adverse infectious events and continued vigilance to define the benefits and risks of FMT across different patient populations are warranted.
https://www.nejm.org/doi/full/10.1056/NEJMoa1910437
Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
Fecal microbiota transplantation (#FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor by means of genomic sequencing. One of the patients died.
Enhanced donor screening to limit the transmission of microorganisms that could lead to adverse infectious events and continued vigilance to define the benefits and risks of FMT across different patient populations are warranted.
https://www.nejm.org/doi/full/10.1056/NEJMoa1910437
New England Journal of Medicine
Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant | NEJM
Original Article from The New England Journal of Medicine — Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant