Study suggests how "super #aging " older adults retain youthful #memory abilities
http://www.massgeneral.org/about/pressrelease.aspx?id=1987
Understanding which factors protect against memory decline could lead to important advances in preventing and treating age-related memory loss and possibly even various forms of dementia, says Dickerson, who is an associate professor of Neurology at HMS. “We desperately need to understand how some older adults are able to function very well into their seventh, eight, and ninth decades..
http://www.massgeneral.org/about/pressrelease.aspx?id=1987
Understanding which factors protect against memory decline could lead to important advances in preventing and treating age-related memory loss and possibly even various forms of dementia, says Dickerson, who is an associate professor of Neurology at HMS. “We desperately need to understand how some older adults are able to function very well into their seventh, eight, and ninth decades..
Massachusetts General Hospital
Study suggests how
A study by Massachusetts General Hospital investigators examines a group of older adults whose memory performance is equivalent to that of younger individuals and finds that key areas of their brains resemble those of young people.
#Handgrip strength variability during serial testing as an entropic biomarker of #aging: a Poincaré plot analysis
..An observational cross-sectional study was performed on 80 young adults (18–22 years old, mean age 20.01 years) and 80 older people (65–69 years old, mean age 67.13 years), with a sex ratio of 1:1 for both groups..
The analysis of the differences between groups revealed statistically significant results for most HGS-derived indices (p ≤ 0.05), and the magnitude of the differences indicated, in most situations, a large effect size (r > 0.5). Our results demonstrate that the proposed repetitive HGS testing indicates relevant differences between young and older healthy subjects. Through the mathematical modeling of data and the application of the concept of entropy, we provide arguments supporting this new design of HGS testing.
Conclusions
Our results indicate that the variability of HGS during serial testing, which reflects complex repetitive biomechanical functions, represents an efficient indicator for differentiation between young and older hand function patterns from an entropic perspective. In practical terms, the variability of HGS, evaluated by the new serial testing design, can be considered an attractive and relatively simple biomarker to use for gerontological studies.
https://bit.ly/371BOEF
..An observational cross-sectional study was performed on 80 young adults (18–22 years old, mean age 20.01 years) and 80 older people (65–69 years old, mean age 67.13 years), with a sex ratio of 1:1 for both groups..
The analysis of the differences between groups revealed statistically significant results for most HGS-derived indices (p ≤ 0.05), and the magnitude of the differences indicated, in most situations, a large effect size (r > 0.5). Our results demonstrate that the proposed repetitive HGS testing indicates relevant differences between young and older healthy subjects. Through the mathematical modeling of data and the application of the concept of entropy, we provide arguments supporting this new design of HGS testing.
Conclusions
Our results indicate that the variability of HGS during serial testing, which reflects complex repetitive biomechanical functions, represents an efficient indicator for differentiation between young and older hand function patterns from an entropic perspective. In practical terms, the variability of HGS, evaluated by the new serial testing design, can be considered an attractive and relatively simple biomarker to use for gerontological studies.
https://bit.ly/371BOEF
BMC Geriatrics
Hand grip strength variability during serial testing as an entropic biomarker of aging: a Poincaré plot analysis
The Poincaré plot method can be used for both qualitative and quantitative assessment of self-similarity in usually periodic functions, hence the idea of applying it to the study of homeostasis of living organisms. From the analysis of numerous scientific…
#Diet modulates brain network stability, a biomarker for brain #aging, in young adults
https://2medical.news/2020/03/28/diet-modulates-brain-network-stability-a-biomarker-for-brain-aging-in-young-adults/
..One cohort was scanned under standard diet, overnight fasting, and ketogenic diet conditions. To isolate the impact of fuel type, an independent overnight fasted cohort was scanned before and after administration of a calorie-matched glucose and exogenous ketone ester (D-β-hydroxybutyrate) bolus. Across the life span, brain network destabilization correlated with decreased brain activity and cognitive acuity. Effects emerged at 47 y, with the most rapid …
https://2medical.news/2020/03/28/diet-modulates-brain-network-stability-a-biomarker-for-brain-aging-in-young-adults/
..One cohort was scanned under standard diet, overnight fasting, and ketogenic diet conditions. To isolate the impact of fuel type, an independent overnight fasted cohort was scanned before and after administration of a calorie-matched glucose and exogenous ketone ester (D-β-hydroxybutyrate) bolus. Across the life span, brain network destabilization correlated with decreased brain activity and cognitive acuity. Effects emerged at 47 y, with the most rapid …
#Aging and comorbidities influence the risk of hospitalization and mortality in #diabetic patients experiencing severe hypoglycemia
https://2medical.news/2021/09/29/aging-and-comorbidities-influence-the-risk-of-hospitalization-and-mortality-in-diabetic-patients-experiencing-severe-hypoglycemia/
https://2medical.news/2021/09/29/aging-and-comorbidities-influence-the-risk-of-hospitalization-and-mortality-in-diabetic-patients-experiencing-severe-hypoglycemia/
2Medical.News
#Aging and comorbidities influence the risk of hospitalization and mortality in #diabetic patients experiencing severe hypoglycemia
Severe hypoglycemia requiring access to the Emergency Department is more frequent in older patients with multiple comorbidities.•Risk of hospitalization and mortality within one year since the hypo…
Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
https://2medical.news/2021/11/13/charting-host-microbe-co-metabolism-in-skin-aging-and-application-to-metagenomics-data/
https://2medical.news/2021/11/13/charting-host-microbe-co-metabolism-in-skin-aging-and-application-to-metagenomics-data/
2Medical.News
Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence…
#Constipation Associated with #Cognitive #Aging and Decline
https://2medical.news/2023/07/31/constipation-associated-with-cognitive-aging-and-decline/
https://2medical.news/2023/07/31/constipation-associated-with-cognitive-aging-and-decline/
2Medical.News
#Constipation Associated with #Cognitive #Aging and Decline
Key Takeaways:Chronic constipation — one bowel movement every three days or more — could signal worsening cognition.People who were chronically constipated had worse cognition equal to three years …
OXR1 maintains the retromer to delay brain #aging under #dietary restriction
https://2medical.news/2024/01/23/oxr1-maintains-the-retromer-to-delay-brain-aging-under-dietary-restriction/
https://2medical.news/2024/01/23/oxr1-maintains-the-retromer-to-delay-brain-aging-under-dietary-restriction/
2Medical.News
OXR1 maintains the retromer to delay brain #aging under #dietary restriction
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR…
#Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
https://2medical.news/2024/03/25/diet-pace-of-biological-aging-and-risk-of-dementia-in-the-framingham-heart-study/
https://2medical.news/2024/03/25/diet-pace-of-biological-aging-and-risk-of-dementia-in-the-framingham-heart-study/
2Medical.News
#Diet, Pace of Biological #Aging, and Risk of #Dementia in the Framingham Heart Study
AbstractObjectivePeople who eat healthier diets are less likely to develop dementia, but the biological mechanism of this protection is not well understood. We tested the hypothesis that healthy di…