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Hysterectomy Uniquely Impacts Spatial #Memory in a Rat Model: A Role for the Nonpregnant #Uterus in Cognitive Processes
https://academic.oup.com/endo/advance-article-abstract/doi/10.1210/en.2018-00709/5154748?redirectedFrom=fulltext
Performance did not differ amongst groups in reference memory–only tasks, suggesting that the working memory domain is particularly sensitive to variations in surgical menopause. Following uterus removal, ovarian histology and estrous cycle monitoring demonstrated that ovaries continued to function, and serum assays indicated altered ovarian hormone and gonadotropin profiles by 2 months after surgery.
These results underscore the critical need to further study the contribution of the uterus to the female phenotype, including effects of hysterectomy with and without ovarian conservation, on the trajectory of brain and endocrine aging to decipher the impact of common variations in gynecological surgery in women.
Moreover, findings demonstrate that the nonpregnant uterus is not dormant, and indicate that there is an ovarian-uterus-brain system that becomes interrupted when the reproductive tract has been disrupted, leading to alterations in brain functioning.
Hysterectomy Uniquely Impacts Spatial #Memory in a Rat Model: A Role for the Nonpregnant #Uterus in Cognitive Processes
https://academic.oup.com/endo/advance-article-abstract/doi/10.1210/en.2018-00709/5154748?redirectedFrom=fulltext
Performance did not differ amongst groups in reference memory–only tasks, suggesting that the working memory domain is particularly sensitive to variations in surgical menopause. Following uterus removal, ovarian histology and estrous cycle monitoring demonstrated that ovaries continued to function, and serum assays indicated altered ovarian hormone and gonadotropin profiles by 2 months after surgery.
These results underscore the critical need to further study the contribution of the uterus to the female phenotype, including effects of hysterectomy with and without ovarian conservation, on the trajectory of brain and endocrine aging to decipher the impact of common variations in gynecological surgery in women.
Moreover, findings demonstrate that the nonpregnant uterus is not dormant, and indicate that there is an ovarian-uterus-brain system that becomes interrupted when the reproductive tract has been disrupted, leading to alterations in brain functioning.