Association of Prenatal #Ultrasonography and #Autism Spectrum Disorder
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2672728
A total of 420 participants were included in the study (328 boys 78.1% and 92 girls 21.9%; mean age as of January 1, 2016, 6.6 years; 95% CI, 6.5-6.8 years). The ASD group received a mean of 5.9 scans (95% CI, 5.2-6.6), which was not significantly different from the 6.1 scans (95% CI, 5.4-6.8) in the developmental delay group or the 6.3 scans (95% CI, 5.8-6.8) in the typical development group. Compared with the typical development group, the ASD group had shorter duration of ultrasound exposure during the first (290.4 seconds 95% CI, 212.8-368.0 seconds vs 406.4 seconds 95% CI, 349.5-463.3 seconds) and second (1687.6 seconds 95% CI, 1493.8-1881.4 seconds vs 2011.0 seconds 95% CI, 1868.9-2153.1 seconds) trimesters but no difference in the number of scans. The ASD group had greater mean depth of ultrasonographic penetration than the developmental delay group in the first trimester (12.5 cm 95% CI, 12.0-13.0 cm vs 11.6 cm 95% CI, 11.1-12.1 cm). The ASD group had greater mean depth than the typical development group during the first (12.5 cm 95% CI, 12.0-13.0 cm vs 11.6 cm 95% CI, 11.3-12.0 cm) and the second (12.9 cm 95% CI, 12.6-13.3 cm vs 12.5 cm 95% CI, 12.2-12.7 cm) trimesters.
Conclusions and Relevance This study found significantly greater mean depth of ultrasonographic penetration in the ASD group compared with the developmental delay group in the first trimester and compared with the typical development group in the first and second trimesters.
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2672728
A total of 420 participants were included in the study (328 boys 78.1% and 92 girls 21.9%; mean age as of January 1, 2016, 6.6 years; 95% CI, 6.5-6.8 years). The ASD group received a mean of 5.9 scans (95% CI, 5.2-6.6), which was not significantly different from the 6.1 scans (95% CI, 5.4-6.8) in the developmental delay group or the 6.3 scans (95% CI, 5.8-6.8) in the typical development group. Compared with the typical development group, the ASD group had shorter duration of ultrasound exposure during the first (290.4 seconds 95% CI, 212.8-368.0 seconds vs 406.4 seconds 95% CI, 349.5-463.3 seconds) and second (1687.6 seconds 95% CI, 1493.8-1881.4 seconds vs 2011.0 seconds 95% CI, 1868.9-2153.1 seconds) trimesters but no difference in the number of scans. The ASD group had greater mean depth of ultrasonographic penetration than the developmental delay group in the first trimester (12.5 cm 95% CI, 12.0-13.0 cm vs 11.6 cm 95% CI, 11.1-12.1 cm). The ASD group had greater mean depth than the typical development group during the first (12.5 cm 95% CI, 12.0-13.0 cm vs 11.6 cm 95% CI, 11.3-12.0 cm) and the second (12.9 cm 95% CI, 12.6-13.3 cm vs 12.5 cm 95% CI, 12.2-12.7 cm) trimesters.
Conclusions and Relevance This study found significantly greater mean depth of ultrasonographic penetration in the ASD group compared with the developmental delay group in the first trimester and compared with the typical development group in the first and second trimesters.