Rapid and sustained symptom reduction following #psilocybin treatment for #anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

http://m.jop.sagepub.com/content/30/12/1165

In conjunction with psychotherapy, single moderate-dose psilocybin produced rapid, robust and enduring anxiolytic and anti-depressant effects in patients with cancer-related psychological distress.

Effects of #Psilocybin-Assisted Therapy on Major #Depressive Disorder
https://2medical.news/2020/11/08/effects-of-psilocybin-assisted-therapy-on-major-depressive-disorder/

Major depressive disorder (MDD) is a substantial public health burden, but current treatments have limited effectiveness and adherence. Recent evidence suggests that 1 or 2 administrations of psilocybin with psychological support produces antidepressant effects in patients with cancer and in those with treatment-resistant depression.. ..Two psilocybin sessions (session 1: 20 mg/70 kg; session 2: 30 mg/70 kg) were given (administered in opaque gelatin capsules with …

Trial of #Psilocybin versus #Escitalopram for Depression
https://2medical.news/2021/04/16/trial-of-psilocybin-versus-escitalopram-for-depression/

Psilocybin may have antidepressant properties, but direct comparisons between psilocybin and established treatments for depression are lacking. METHODS In a phase 2, double-blind, randomized, controlled trial involving patients with long-standing, moderate-to-severe major depressive disorder, we compared psilocybin with escitalopram, a selective serotonin-reuptake inhibitor, over a 6-week period. Patients were assigned in a 1:1 ratio to receive two separate doses of 25 mg of psilocybin 3 …

#Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo

https://2medical.news/2021/07/12/psilocybin-induces-rapid-and-persistent-growth-of-dendritic-spines-in-frontal-cortex-in-vivo/