Daily supplementation with 15 μg vitamin #D2 compared with vitamin #D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial
http://m.ajcn.nutrition.org/content/early/2017/07/04/ajcn.116.138693.abstract
There are conflicting views in the literature as to whether vitamin D2 and vitamin D3 are equally effective in increasing and maintaining serum concentrations of 25-hydroxyvitamin D 25(OH)D, particularly at lower doses of vitamin D.
Conclusions: With the use of a daily dose of vitamin D relevant to public health recommendations (15 μg) and in vehicles relevant to food-fortification strategies, vitamin D3 was more effective than vitamin D2 in increasing serum 25(OH)D in the wintertime. Vitamin D3 may therefore be a preferential form to optimize vitamin D status within the general population.
http://m.ajcn.nutrition.org/content/early/2017/07/04/ajcn.116.138693.abstract
There are conflicting views in the literature as to whether vitamin D2 and vitamin D3 are equally effective in increasing and maintaining serum concentrations of 25-hydroxyvitamin D 25(OH)D, particularly at lower doses of vitamin D.
Conclusions: With the use of a daily dose of vitamin D relevant to public health recommendations (15 μg) and in vehicles relevant to food-fortification strategies, vitamin D3 was more effective than vitamin D2 in increasing serum 25(OH)D in the wintertime. Vitamin D3 may therefore be a preferential form to optimize vitamin D status within the general population.
Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional #endothelium by 1,25-dihydroxy vitamin #D3 – clinical implications for cardiovascular diseases
https://www.dovepress.com/nanomedical-studies-of-the-restoration-of-nitric-oxideperoxynitrite-ba-peer-reviewed-article-IJN
Clinical studies indicate that vitamin D3 improves circulation and may have beneficial effects in hypertension. This study uses nanomedical systems to investigate the role of 1,25-dihydroxy vitamin D3 in the preservation/restoration of endothelial function in an angiotensin II (Ang II) cellular model of hypertension
NO/ONOO- imbalance in Ang II-stimulated dysfunctional endothelium was 0.20±0.16 for CAs and 0.11±0.09 for AAs. Uncoupled eNOS and overexpression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributed to high production of ONOO-. Vitamin D3 treatment reversed NO/ONOO- to 3.0±0.1 in CAs and 2.1±0.1 in AAs – exceeding that observed in normal endothelium. Vitamin D3 restored uncoupled eNOS and endothelial function by increasing cytoprotective NO and decreasing the cytotoxic ONOO-. The beneficial effect of vitamin D3 is associated with a favorable rate of NO and ONOO- release, restoration of the NO/ONOO- and the overall decrease in the overexpression of eNOS, inducible nitric oxide synthase and NADPH oxidase. This effect of vitamin D3 may prove to be beneficial in the treatment of hypertension and other cardiovascular diseases, including heart failure, myocardial infarction, vasculopathy, stroke and diabetes
https://www.dovepress.com/nanomedical-studies-of-the-restoration-of-nitric-oxideperoxynitrite-ba-peer-reviewed-article-IJN
Clinical studies indicate that vitamin D3 improves circulation and may have beneficial effects in hypertension. This study uses nanomedical systems to investigate the role of 1,25-dihydroxy vitamin D3 in the preservation/restoration of endothelial function in an angiotensin II (Ang II) cellular model of hypertension
NO/ONOO- imbalance in Ang II-stimulated dysfunctional endothelium was 0.20±0.16 for CAs and 0.11±0.09 for AAs. Uncoupled eNOS and overexpression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase contributed to high production of ONOO-. Vitamin D3 treatment reversed NO/ONOO- to 3.0±0.1 in CAs and 2.1±0.1 in AAs – exceeding that observed in normal endothelium. Vitamin D3 restored uncoupled eNOS and endothelial function by increasing cytoprotective NO and decreasing the cytotoxic ONOO-. The beneficial effect of vitamin D3 is associated with a favorable rate of NO and ONOO- release, restoration of the NO/ONOO- and the overall decrease in the overexpression of eNOS, inducible nitric oxide synthase and NADPH oxidase. This effect of vitamin D3 may prove to be beneficial in the treatment of hypertension and other cardiovascular diseases, including heart failure, myocardial infarction, vasculopathy, stroke and diabetes
Dovepress
Nanomedical studies of the restoration of nitric oxide/peroxynitrite b | IJN
Nanomedical studies of the restoration of nitric oxide/peroxynitrite balance in dysfunctional endothelium by 1,25-dihydroxy vitamin D3 - clinical implications for cardiovascular diseases Alamzeb Khan, Hazem Dawoud, Tadeusz Malinski Department of Chemistry…
!!
Early High-Dose Vitamin #D3 for Critically Ill, Vitamin D–Deficient Patients
Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients..
..A total of 1360 patients were found to be vitamin D–deficient during point-of-care screening and underwent randomization. Of these patients, 1078 had baseline vitamin D deficiency (25-hydroxyvitamin D level, <20 ng per milliliter [50 nmol per liter]) confirmed by subsequent testing and were included in the primary analysis population.
..There were no clinically important differences between the groups with respect to secondary clinical, physiological, or safety end points. The severity of vitamin D deficiency at baseline did not affect the association between the treatment assignment and mortality.
CONCLUSIONS
Early administration of high-dose enteral vitamin D3 did not provide an advantage over placebo with respect to 90-day mortality or other, nonfatal outcomes among critically ill, vitamin D–deficient patients
https://bit.ly/2EsqWmT
Early High-Dose Vitamin #D3 for Critically Ill, Vitamin D–Deficient Patients
Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients..
..A total of 1360 patients were found to be vitamin D–deficient during point-of-care screening and underwent randomization. Of these patients, 1078 had baseline vitamin D deficiency (25-hydroxyvitamin D level, <20 ng per milliliter [50 nmol per liter]) confirmed by subsequent testing and were included in the primary analysis population.
..There were no clinically important differences between the groups with respect to secondary clinical, physiological, or safety end points. The severity of vitamin D deficiency at baseline did not affect the association between the treatment assignment and mortality.
CONCLUSIONS
Early administration of high-dose enteral vitamin D3 did not provide an advantage over placebo with respect to 90-day mortality or other, nonfatal outcomes among critically ill, vitamin D–deficient patients
https://bit.ly/2EsqWmT
New England Journal of Medicine
Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients | NEJM
Original Article from The New England Journal of Medicine — Early High-Dose Vitamin D3 for Critically Ill, Vitamin D–Deficient Patients
Effect of Long-term Vitamin #D3 Supplementation vs Placebo on Risk of Depression or Clinically Relevant #Depressive Symptoms and on Change in Mood Scores A Randomized Clinical Trial
https://2medical.news/2020/08/10/effect-of-long-term-vitamin-d3-supplementation-vs-placebo-on-risk-of-depression-or-clinically-relevant-depressive-symptoms-and-on-change-in-mood-scores-a-randomized-clinical-trial/
Low levels of 25-hydroxyvitamin D have been associated with higher risk for depression later in life, but there have been few long-term, high-dose large-scale trials.. Randomized assignment in a 2 × 2 factorial design to vitamin D3 (2000 IU/d of cholecalciferol) and fish oil or placebo; 9181 were randomized to vitamin D3 and 9172 were randomized to matching placebo.. Among the 18 353 randomized participants (mean age, 67.5 …
https://2medical.news/2020/08/10/effect-of-long-term-vitamin-d3-supplementation-vs-placebo-on-risk-of-depression-or-clinically-relevant-depressive-symptoms-and-on-change-in-mood-scores-a-randomized-clinical-trial/
Low levels of 25-hydroxyvitamin D have been associated with higher risk for depression later in life, but there have been few long-term, high-dose large-scale trials.. Randomized assignment in a 2 × 2 factorial design to vitamin D3 (2000 IU/d of cholecalciferol) and fish oil or placebo; 9181 were randomized to vitamin D3 and 9172 were randomized to matching placebo.. Among the 18 353 randomized participants (mean age, 67.5 …
Effect of Early High-Dose Vitamin #D3 Repletion on Cognitive Outcomes in Critically Ill Adults
https://2medical.news/2021/04/12/effect-of-early-high-dose-vitamin-d3-repletion-on-cognitive-outcomes-in-critically-ill-adults/
Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition. Research Question Does a single high-dose (540,000 IU) enteral treatment of vitamin D3 given shortly after hospital admission in vitamin D deficient, critically-ill patients improve long-term global cognition or executive function? Study Design and Methods This study evaluated long-term cognitive outcomes among patients enrolled in a multicenter, blinded, randomized …
https://2medical.news/2021/04/12/effect-of-early-high-dose-vitamin-d3-repletion-on-cognitive-outcomes-in-critically-ill-adults/
Long-term cognitive impairment frequently occurs after critical illness; no treatments are known to improve long-term cognition. Research Question Does a single high-dose (540,000 IU) enteral treatment of vitamin D3 given shortly after hospital admission in vitamin D deficient, critically-ill patients improve long-term global cognition or executive function? Study Design and Methods This study evaluated long-term cognitive outcomes among patients enrolled in a multicenter, blinded, randomized …