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Interplay of Objective #sleep Duration and Cardiovascular and #Cerebrovascular Diseases on Cause‐Specific Mortality
Objective short sleep duration was defined as polysomnographic total sleep time <6 hours. Cox proportional hazard models estimated multivariable‐adjusted hazard ratios (HRs) and 95% CIs. Risk of all‐cause mortality associated with CMR or CBVD was significantly modified by objective sleep duration (P<0.05), and it was significantly higher in subjects who slept <6 hours (HR, 2.14 [95% CI, 1.52–3.02] and HR, 3.17 [95% CI=2.16–4.65], respectively). In subjects who slept <6 hours, CMR was associated with a 1.83 higher (95% CI, 1.07–3.13) risk of CBVD mortality and CBVD with a 2.92 higher (95% CI, 1.28–6.65) risk of cancer mortality. In subjects who slept ≥6 hours, CMR was not significantly associated with CBVD mortality (HR, 1.35; 95% CI, 0.70–2.63) nor was CBVD significantly associated with cancer mortality (HR, 0.55; 95% CI, 0.18–1.64).
Conclusions
Objective short sleep duration predicts the all‐cause mortality prognosis of middle‐aged adults with CMR and the cancer‐specific mortality prognosis of those with CBVD.
https://www.ahajournals.org/doi/10.1161/JAHA.119.013043
Interplay of Objective #sleep Duration and Cardiovascular and #Cerebrovascular Diseases on Cause‐Specific Mortality
Objective short sleep duration was defined as polysomnographic total sleep time <6 hours. Cox proportional hazard models estimated multivariable‐adjusted hazard ratios (HRs) and 95% CIs. Risk of all‐cause mortality associated with CMR or CBVD was significantly modified by objective sleep duration (P<0.05), and it was significantly higher in subjects who slept <6 hours (HR, 2.14 [95% CI, 1.52–3.02] and HR, 3.17 [95% CI=2.16–4.65], respectively). In subjects who slept <6 hours, CMR was associated with a 1.83 higher (95% CI, 1.07–3.13) risk of CBVD mortality and CBVD with a 2.92 higher (95% CI, 1.28–6.65) risk of cancer mortality. In subjects who slept ≥6 hours, CMR was not significantly associated with CBVD mortality (HR, 1.35; 95% CI, 0.70–2.63) nor was CBVD significantly associated with cancer mortality (HR, 0.55; 95% CI, 0.18–1.64).
Conclusions
Objective short sleep duration predicts the all‐cause mortality prognosis of middle‐aged adults with CMR and the cancer‐specific mortality prognosis of those with CBVD.
https://www.ahajournals.org/doi/10.1161/JAHA.119.013043
Journal of the American Heart Association
Interplay of Objective Sleep Duration and Cardiovascular and Cerebrovascular Diseases on Cause‐Specific Mortality | Journal of…
BackgroundCardiovascular and cerebrovascular diseases (CBVDs) and cancer are leading causes of death. Short sleep is a potential contributor to health; however, its role in predicting mortality ass...
#Cerebrovascular and Neurological Dysfunction under the Threat of #COVID-19: Is There a Comorbid Role for #Smoking and Vaping?
https://2medical.news/2020/07/28/cerebrovascular-and-neurological-dysfunction-under-the-threat-of-covid-19-is-there-a-comorbid-role-for-smoking-and-vaping/
The recently discovered novel coronavirus, SARS-CoV-2 (COVID-19 virus), has brought the whole world to standstill with critical challenges, affecting both health and economic sectors worldwide. Although initially, this pandemic was associated with causing severe pulmonary and respiratory disorders, recent case studies reported the association of cerebrovascular-neurological dysfunction in COVID-19 patients, which is also life-threatening. Several SARS-CoV-2 positive case studies have been reported where there are …
https://2medical.news/2020/07/28/cerebrovascular-and-neurological-dysfunction-under-the-threat-of-covid-19-is-there-a-comorbid-role-for-smoking-and-vaping/
The recently discovered novel coronavirus, SARS-CoV-2 (COVID-19 virus), has brought the whole world to standstill with critical challenges, affecting both health and economic sectors worldwide. Although initially, this pandemic was associated with causing severe pulmonary and respiratory disorders, recent case studies reported the association of cerebrovascular-neurological dysfunction in COVID-19 patients, which is also life-threatening. Several SARS-CoV-2 positive case studies have been reported where there are …
#Cerebrovascular Effects of #Sildenafil in Small Vessel Disease: The OxHARP Trial
https://2medical.news/2024/06/17/cerebrovascular-effects-of-sildenafil-in-small-vessel-disease-the-oxharp-trial/
https://2medical.news/2024/06/17/cerebrovascular-effects-of-sildenafil-in-small-vessel-disease-the-oxharp-trial/
2Medical.News
#Cerebrovascular Effects of #Sildenafil in Small Vessel Disease: The OxHARP Trial
BACKGROUND:Vascular cognitive impairment due to cerebral small vessel disease is associated with cerebral pulsatility, white matter hypoperfusion, and reduced cerebrovascular reactivity (CVR), and …
#Overweight in #Adolescence and Young Adulthood in Association With Adult #Cerebrovascular Disease: The NFBC1966 Study
https://2medical.news/2024/06/28/overweight-in-adolescence-and-young-adulthood-in-association-with-adult-cerebrovascular-disease-the-nfbc1966-study/
https://2medical.news/2024/06/28/overweight-in-adolescence-and-young-adulthood-in-association-with-adult-cerebrovascular-disease-the-nfbc1966-study/
2Medical.News
#Overweight in #Adolescence and Young Adulthood in Association With Adult #Cerebrovascular Disease: The NFBC1966 Study
BACKGROUND:Risk factors for cerebrovascular disease in adulthood are well known. However, research on individuals’ risk factors throughout their life span has been limited. This prospective cohort …