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Aldo Lorenzetti M.D, Internal Medicine & Hepatology, Milano - SIMEDET Delegate
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Effect of Gastric #Bypass on #Bone Mineral Density, Parathyroid Hormone and Vitamin D: 5 Years Follow-up
https://link.springer.com/article/10.1007/s11695-016-2114-3

The aim of the present study was to see if there are longitudinal changes in bone mineral density (BMD), vitamin D or parathyroid hormone (PTH) in females 5 years after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) The mean decrease in BMI between baseline and 5 years after surgery was 29.4 %. BMD of the spine and femur measured as z- and t-scores, showed a linear, statistically significant declining trend over the years. The fall in BMD of the spine and femoral neck between baseline and 5 years after surgery was 19 and 25 %, respectively. The mean fP-PTH showed a significant increase over the study period (20.2 μg/L increase, 95 % CI:−31.99 to −8.41). S-calcium, both free and corrected for albumin, showed a decrease between baseline and 5 years after surgery.

Eight patients developed osteopenia and one osteoporosis after a 5-year follow-up.

Conclusion

LRYGB is an efficient method for sustained long-term body weight loss. There is, however, a concomitant decrease in BMD and S-calcium, and an increase in fP-PTH
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Gastro-Esophageal #Reflux Disease After Laparoscopic Mini-Gastric #Bypass and Roux-en-Y Gastric Bypass: Is There a Difference?

https://www.liebertpub.com/doi/10.1089/bari.2018.0018

The operative time was significantly longer in RYGB group compared to MGB group (p < 0.001). The percentage of excess weight loss was slightly higher in the MGB group after 6 months (p = 0.096). There were no cases of leakage or mortalities in the two groups. Complications were recorded in 30% of the MGB group and 40% of the RYGB group. Biliary reflux was detected endoscopically in 11 patients (36.6%) in the MGB group and none of the RYGB group. GERD symptoms were exaggerated in MGB group after 1 month compared to RYGB group (p = 0.008). At 12 months, symptoms improved significantly in the two groups; the scores were nonsignificantly higher in MGB group (p = 0.088). Esophagitis was more common in the MGB group than RYGB group (p = 0.008).

Conclusion: Laparoscopic Roux-en-Y gastric bypass and laparoscopic mini-gastric bypass appear to be equally effective in the treatment of morbid obesity regarding weight loss and resolution of obesity-related metabolic complications. On short-term follow-up, MGB exaggerated GERD symptoms, but in the long run, symptoms decreased markedly.
Effects of #Diet versus Gastric #Bypass on Metabolic Function in Diabetes
https://2medical.news/2020/08/24/effects-of-diet-versus-gastric-bypass-on-metabolic-function-in-diabetes/

Some studies have suggested that in people with type 2 diabetes, Roux-en-Y gastric bypass has therapeutic effects on metabolic function that are independent of weight loss.. ..Weight loss was associated with increases in mean suppression of glucose production from baseline, by 7.04 μmol per kilogram of fat-free mass per minute (95% confidence interval [CI], 4.74 to 9.33) in the diet group and by 7.02 μmol …