Truly transmissible cancers

Ulcers

It's a compressive neuropathy of the radial nerve (C5-T1) that leads to motor and sensory deficits in the radial nerve distribution.

It usually results from continuous pressure on the medial aspect of the arm; like when a lover sleeps on your arm all night, hence the name (honeymoon palsy). It can also result from pressure on the axilla, which classically occurs when an intoxicated person sleeps with their arm dangling over a chair or some other hard surface, hence the name (saturday night palsy). Other causes include the use of crutches.

Symptoms may take several days following the provoking event, resulting in a delayed presentation.

TZDs (Thiazolidinediones), which are oral anti-diabetic drugs, have a positive effect on glucose and lipid metabolism. These agents (especially pioglitazone) activate the PPAR-gamma receptors leading to lower levels of HbA1c, and more insulin-sensitivity. They also activate the PPAR-alpha receptor (the same target for fibrate drugs) which then lowers triglycerides, and LDL. Thus they can be helpful in cases of concomitant DM-2 and non-alcoholic fatty liver disease.

But they can also cause water and sodium retention, therefore they might have an adverse effects on congestive heart disease.

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Fibrates, which are lipid-lowering agents that lower triglycerides, work on a similar receptor, PPAR-alpha.

Tests for multiple myeloma (and other monoclonal gammopathies)

*MGUS: Monoclonal Gammopathy of Unknown Significance

Allopurinol is first-line urate-lowering agent. We switch to febuxostat only if the patient can't tolerate allopurinol or if it's contraindicated (as in CKD where its dose must be adjusted). Also, remember that Febuxostat increases cardiovascular and all-cause mortality.

Calcium physiology (including PTH, vitamin D, and calcitonin)

الله بالخير عليكم

يكلك رايدين جهاز ضغط زئبقي اصلي، وين نلكة؟ (يفضّل مكان مجربين أجهزته سابقًا)
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